Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$180K - $268K *

Transform your career by leading regulatory strategies for complex transactions in reinsurance and M&A. Collaborate with global teams to navigate regulatory landscapes and ensure compliance while driv...

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$126K - $188K *

Drive operational risk enablement across regions by translating enterprise frameworks, building practitioner capabilities, and ensuring compliance with local regulations while fostering strong stakeho...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$78K - $110K *

Contribute to high-quality pre and post-closing services in real estate underwriting. Collaborate with teams to analyze market data, assist in credit presentations, and ensure compliance with loan ter...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$177K - $236K *

Advance your career by leading complex insurance transactions, structuring innovative legal agreements, and collaborating with cross-functional teams to drive strategic initiatives in a dynamic remote...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$119K - $199K *

Lead the charge in delivering exceptional service and maintenance solutions, managing customer relationships, and driving operational excellence in the power generation sector. Your expertise will enh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$78K - $131K *

Advance your career by supporting critical power systems projects. As a Field Service Engineer, you'll perform installations and troubleshooting, ensuring technical integrity while delivering exceptio...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

$129K - $214K *

Join a dynamic team as a senior leader in EHS, driving safety and compliance for a groundbreaking nuclear construction project. Lead a multidisciplinary team, ensuring the highest safety standards acr...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Business Services

$128K - $214K *

Champion the branding and marketing strategy for HVDC, FACTS, and ACIS portfolios. Collaborate with cross-functional teams to enhance market positioning, execute product launches, and drive customer e...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$154K - $258K *

Transform project management excellence by leading the Power Transmission portfolio, ensuring operational alignment, driving financial performance, and fostering talent development across a matrix org...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Business Services

$190K - $280K *

Transform operations and financial performance for Wind Services, overseeing 800+ technicians across 200 sites. Drive safety, compliance, and customer relations while enhancing operational processes a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$111K - $186K *

Optimize security architecture for cloud and on-premise systems. Collaborate with teams to ensure secure designs, conduct risk assessments, and develop reusable guidance. Leverage your cybersecurity e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$151K - $252K *

Pioneer innovative sales strategies for stability solutions in data centers. Drive growth by managing key customer relationships and executing commercial objectives across North America, ensuring high...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

$156K - $247K *

Optimize oncology marketing strategies by leveraging data-driven insights, collaborating with cross-functional teams, and enhancing patient engagement to maximize business impact and drive effective m...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Help us lead and optimize global Order-to-Cash operations, overseeing billing, collections, and accounts receivable. Drive cross-functional partnerships, enhance workflows, and manage a high-performin...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$111K - $167K *

Drive impactful marketing strategies by leveraging data analysis and AI tools. Collaborate cross-functionally to enhance funnel performance, ROI modeling, and operational efficiency, ensuring alignmen...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$290K - $436K *

Elevate our mobile engineering organization by leading teams, driving modernization, and ensuring app performance and quality. Collaborate with cross-functional partners to innovate and mentor future...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$73K - $132K *

Empower your career by leading mission operations as a Site Lead. Engage with teams, solve challenges, and ensure operational success while fostering strong relationships with stakeholders in a dynami...

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$87K - $157K *

Lead the charge in designing and reviewing structural components for substation and transmission projects, ensuring quality control and mentoring junior engineers while engaging with clients and suppo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$185K - $344K *

Transform analytics modernization and productivity by leading strategy, governance, and process evolution. Collaborate with cross-functional teams to enhance workflows, drive AI adoption, and optimize...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$129K - $218K *

Unlock potential by driving strategic sales initiatives and operational improvements. Collaborate with leaders to enhance performance, resource allocation, and growth, transforming data into actionabl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$125K - $130K *

Join a dynamic team as a Senior Cybersecurity Analyst, focusing on IT service recovery and business continuity. Collaborate with federal staff to develop strategies that ensure operational resilience...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$84K - $187K *

Join the AI Automation team to innovate and implement AI solutions that enhance efficiency and security. Collaborate with experts to build automations, connect systems, and experiment with cutting-edg...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$165K - $195K *

Lead the charge in developing and managing a robust Enterprise Data Warehouse on Databricks. Drive BI solutions, mentor a team, and ensure data quality while collaborating across departments to enhanc...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $171K *

Transform client success by delivering tailored support and strategic insights, ensuring seamless onboarding and ongoing engagement with our innovative platform. Leverage your expertise in energy engi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Champion oral health excellence by diagnosing and treating patients' dental needs, supervising procedures, and educating the community, while leading a dedicated team in a supportive healthcare enviro...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.