Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$120K - $131K *
Transform IT business processes through analysis and automation, enhancing efficiency and compliance. Leverage tools like Microsoft Power Platform and ServiceNow to align technology with strategic goa...
1 week ago
$95K - $115K *
Lead the charge in delivering expert pediatric healthcare, focusing on critical care and oncology. Collaborate with multidisciplinary teams to create individualized care plans, educate families, and c...
1 week ago
Quality & Compliance Manager, Computer System Validation
$91K - $120K *
Drive quality assurance and compliance for GxP computerized systems, ensuring data integrity and regulatory adherence throughout the system lifecycle. Collaborate with cross-functional teams to enhanc...
Reposted 1 week ago
Senior Success Lead, Public Sector
$140K - $175K *
Empower your career by driving impactful relationships in government sectors. Manage a dedicated account portfolio, enhance customer satisfaction, and lead strategic engagement initiatives to maximize...
1 week ago
Senior Technical Support Engineer - Shifted Work Week
$70K - $100K *
Champion seamless customer experiences by resolving technical issues and collaborating cross-functionally. Leverage your expertise to enhance product reliability and drive customer satisfaction in a d...
1 week ago
Senior Director Access Experience Team
$191K - $280K *
The Senior Director of the Access Experience Team will lead strategic initiatives for clients in the pharmaceutical and life sciences sectors, focusing on payer marketing and access strategies. This r...
Reposted 1 week ago
Senior Data Analytics Engineer
$95K - $120K *
Unlock potential by delivering actionable insights through data analysis, visualization, and reporting. Collaborate across departments to enhance decision-making with automated dashboards and performa...
1 week ago
Service Manager, Preventative Maintenance (U.S.)
$95K - $115K *
Join a team that's dedicated to enhancing equipment reliability through strategic leadership of preventive maintenance programs. Drive quality control, compliance, and continuous improvement while man...
1 week ago
Director, Advanced Analytics and Modeling - Key Drivers & Actions (KDA)
$194K - $361K *
Reimagine your career by leading advanced analytics initiatives that drive enterprise performance. Collaborate across functions to translate insights into strategic actions, enhancing growth and marke...
1 week ago
$62K - $119K *
Join a team that's dedicated to enhancing billing processes and team development. Oversee daily operations, manage performance, and drive strategic improvements while supporting a dynamic billing depa...
1 week ago
$112K - $127K *
Elevate your career by supporting the design and maintenance of enterprise WAN infrastructure. Collaborate with diverse teams to ensure network reliability and performance across multiple locations, e...
1 week ago
Senior HR Business Partner, Claude Corps
$110K - $150K *
Join a team that's redefining HR support for a growing fellowship program. You'll oversee onboarding, advise managers, and enhance employee relations while ensuring a seamless experience for fellows a...
1 week ago
$85K - $90K *
Drive strategic sales initiatives to acquire new clients in government and education sectors. Collaborate with stakeholders to deliver innovative solutions, exceed quotas, and enhance client relations...
1 week ago
$80K - $95K *
Champion customer success by driving account growth, retention, and adoption. Collaborate with government clients to ensure alignment with product capabilities, influence strategy, and contribute to o...
1 week ago
$83K - $107K *
Join our team as a Donor Assessment Coordinator, where you'll play a key role in screening organ offers, coordinating donor assessments, and ensuring effective communication among transplant teams to...
1 week ago
$200K - $225K *
Elevate your career by developing strategic partnerships with pharmaceutical manufacturers. Drive innovative agreements that enhance medication access and affordability while managing the full deal cy...
1 week ago
ABM Manager, Strategic Products
$136K - $160K *
Optimize account-based marketing strategies to drive engagement and sales for new products. Lead end-to-end campaign execution, asset production, and pipeline accountability while collaborating closel...
1 week ago
Senior Software Engineer, Enterprise AI
$199K - $210K *
Unlock potential by joining a dynamic team to design and develop scalable AI solutions. Collaborate across disciplines to transform complex challenges into impactful products, driving innovation and e...
1 week ago
Account Executive - Salesforce Solutions
$110K - $130K *
Champion innovative Salesforce solutions by driving sales and fostering client relationships. Engage throughout the customer lifecycle to ensure successful deployments and identify growth opportunitie...
1 week ago
$150K - $160K *
Shape the future of user experience by driving product adoption and enhancing workflows in a leading password manager. Collaborate cross-functionally to ensure seamless onboarding and retention for bo...
Reposted 1 week ago
Application Engineer - RF Test, AZ
$115K - $190K *
Join a team that's dedicated to solving complex RF and Microwave challenges. Collaborate with engineers and scientists to deliver innovative solutions, provide technical support, and enhance customer...
1 week ago
$340K - $445K *
Lead the global communications strategy to enhance brand visibility and thought leadership. Oversee internal and external communications, manage crisis situations, and mentor a high-performing team to...
1 week ago
$220K - $245K *
Join us in overseeing regulatory affairs activities, developing strategies for clinical trials, and managing global submissions to ensure compliance and product approvals in a dynamic pharmaceutical e...
1 week ago
$90K - $120K *
Manage the delivery of security engagements, ensuring alignment among clients, engineers, and internal teams. Oversee project timelines, documentation, and communication to deliver high-quality result...
1 week ago
AVP, Casualty Underwriting Performance - E&S/Specialty and Commercial Lines
$154K - $290K *
Champion strategic initiatives in casualty underwriting, driving performance and innovation across multiple business lines. Collaborate with cross-functional teams to align underwriting strategy with...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.