Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$120K - $131K *

Transform IT business processes through analysis and automation, enhancing efficiency and compliance. Leverage tools like Microsoft Power Platform and ServiceNow to align technology with strategic goa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Lead the charge in delivering expert pediatric healthcare, focusing on critical care and oncology. Collaborate with multidisciplinary teams to create individualized care plans, educate families, and c...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$91K - $120K *

Drive quality assurance and compliance for GxP computerized systems, ensuring data integrity and regulatory adherence throughout the system lifecycle. Collaborate with cross-functional teams to enhanc...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $175K *

Empower your career by driving impactful relationships in government sectors. Manage a dedicated account portfolio, enhance customer satisfaction, and lead strategic engagement initiatives to maximize...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $100K *

Champion seamless customer experiences by resolving technical issues and collaborating cross-functionally. Leverage your expertise to enhance product reliability and drive customer satisfaction in a d...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$191K - $280K *

The Senior Director of the Access Experience Team will lead strategic initiatives for clients in the pharmaceutical and life sciences sectors, focusing on payer marketing and access strategies. This r...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $120K *

Unlock potential by delivering actionable insights through data analysis, visualization, and reporting. Collaborate across departments to enhance decision-making with automated dashboards and performa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Join a team that's dedicated to enhancing equipment reliability through strategic leadership of preventive maintenance programs. Drive quality control, compliance, and continuous improvement while man...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$194K - $361K *

Reimagine your career by leading advanced analytics initiatives that drive enterprise performance. Collaborate across functions to translate insights into strategic actions, enhancing growth and marke...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$62K - $119K *

Join a team that's dedicated to enhancing billing processes and team development. Oversee daily operations, manage performance, and drive strategic improvements while supporting a dynamic billing depa...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$112K - $127K *

Elevate your career by supporting the design and maintenance of enterprise WAN infrastructure. Collaborate with diverse teams to ensure network reliability and performance across multiple locations, e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $150K *

Join a team that's redefining HR support for a growing fellowship program. You'll oversee onboarding, advise managers, and enhance employee relations while ensuring a seamless experience for fellows a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$85K - $90K *

Drive strategic sales initiatives to acquire new clients in government and education sectors. Collaborate with stakeholders to deliver innovative solutions, exceed quotas, and enhance client relations...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Champion customer success by driving account growth, retention, and adoption. Collaborate with government clients to ensure alignment with product capabilities, influence strategy, and contribute to o...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$83K - $107K *

Join our team as a Donor Assessment Coordinator, where you'll play a key role in screening organ offers, coordinating donor assessments, and ensuring effective communication among transplant teams to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $225K *

Elevate your career by developing strategic partnerships with pharmaceutical manufacturers. Drive innovative agreements that enhance medication access and affordability while managing the full deal cy...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$136K - $160K *

Optimize account-based marketing strategies to drive engagement and sales for new products. Lead end-to-end campaign execution, asset production, and pipeline accountability while collaborating closel...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$199K - $210K *

Unlock potential by joining a dynamic team to design and develop scalable AI solutions. Collaborate across disciplines to transform complex challenges into impactful products, driving innovation and e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $130K *

Champion innovative Salesforce solutions by driving sales and fostering client relationships. Engage throughout the customer lifecycle to ensure successful deployments and identify growth opportunitie...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $160K *

Shape the future of user experience by driving product adoption and enhancing workflows in a leading password manager. Collaborate cross-functionally to ensure seamless onboarding and retention for bo...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $190K *

Join a team that's dedicated to solving complex RF and Microwave challenges. Collaborate with engineers and scientists to deliver innovative solutions, provide technical support, and enhance customer...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$340K - $445K *

Lead the global communications strategy to enhance brand visibility and thought leadership. Oversee internal and external communications, manage crisis situations, and mentor a high-performing team to...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Consumer Technology

$220K - $245K *

Join us in overseeing regulatory affairs activities, developing strategies for clinical trials, and managing global submissions to ensure compliance and product approvals in a dynamic pharmaceutical e...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $120K *

Manage the delivery of security engagements, ensuring alignment among clients, engineers, and internal teams. Oversee project timelines, documentation, and communication to deliver high-quality result...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$154K - $290K *

Champion strategic initiatives in casualty underwriting, driving performance and innovation across multiple business lines. Collaborate with cross-functional teams to align underwriting strategy with...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.