Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior Director, Regulatory Business Operations
$148K - $274K *
Partner with us to navigate complex regulatory environments, ensuring compliance and facilitating business expansions. Leverage your expertise to advise leadership and manage licensure processes effec...
Reposted 1 week ago
Program Manager IV - Clinical Technology Operations
$87K - $157K *
Manage strategic programs and complex projects, ensuring timely delivery while effectively leading cross-functional teams to achieve key business objectives and drive organizational success...
Reposted 1 week ago
Manager, Utilization Management
$87K - $161K *
Lead the charge in managing a clinical review team to ensure optimal member care through effective utilization management and compliance with healthcare standards. Drive improvements and foster commun...
1 week ago
$102K - $190K *
Innovate data management processes by leading the development of robust data pipelines, ensuring high-quality data for analytics and reporting. Collaborate with cross-functional teams to enhance data...
Reposted 1 week ago
Digital Communications Automation Specialist
$70K - $126K *
Drive impactful digital content development through Salesforce Marketing Cloud, managing cross-functional communication strategies to enhance member engagement and optimize performance metrics for eff...
1 week ago
Digital Communications Automation Specialist
$70K - $126K *
Transform member engagement by developing digital content through Salesforce Marketing Cloud. Collaborate across teams to manage communication strategies, analyze performance metrics, and enhance user...
1 week ago
Vice President, Ambetter Market Product Development & Management
$171K - $326K *
Strategize product development and market opportunities while collaborating across teams to innovate ACA/Marketplace offerings that meet client needs and drive growth...
1 week ago
$93K - $140K *
Manage customer relationships and drive agronomy solutions by leveraging technical expertise. Collaborate with sales teams to enhance product positioning and execute training, while creating new marke...
1 week ago
$107K - $161K *
Drive local seed sales success by training teams, developing agronomy tools, and assessing market needs. Collaborate with sales and agronomy experts to enhance product strategies and execute effective...
1 week ago
Sales Manager, Foodservice K12 - Southeast Region
$123K - $185K *
Lead K-12 sales initiatives in the Southeast, driving growth through strategic partnerships and culinary collaborations while enhancing product placements and bid success across school districts...
1 week ago
Business Resiliency Specialist III
$94K - $164K *
Drive business continuity and disaster recovery initiatives, ensuring critical operations are sustained and services restored post-disruption. Collaborate with stakeholders to assess risks, validate r...
1 week ago
Project Manager I - Integration/Government Sponsored Healthcare Programs
$62K - $100K *
Join a team that's dedicated to delivering successful projects by managing small complexity initiatives, ensuring milestones are met, and fostering collaboration across business and IT stakeholders fo...
Reposted 1 week ago
$72K - $115K *
Transform the future of digital products by managing their lifecycle, optimizing user experiences, and collaborating with cross-functional teams to drive engagement and adoption while ensuring alignme...
1 week ago
$94K - $164K *
Elevate project outcomes by managing medium to high complexity initiatives, ensuring timely delivery, stakeholder engagement, and adherence to best practices throughout the project lifecycle...
1 week ago
UM Operations Strategy Implementation Lead
$83K - $132K *
Champion operational excellence by leading compliance and process improvements in Utilization Management. Collaborate across teams to identify gaps, drive change, and ensure adherence to regulatory st...
1 week ago
$135K - $160K *
Empower your career as a Principal IAM Engineer, owning the identity control plane and ensuring secure access to sensitive data. Collaborate with cross-functional teams to automate identity processes...
1 week ago
Scientist II - Analytical Chemist
$80K - $95K *
Join a dynamic team to advance analytical chemistry methods and lead projects. Utilize your expertise in LC-MS for bioanalytical applications while mentoring junior scientists and driving innovation i...
1 week ago
Director of Strategy - Innovations
$125K - $150K *
Lead the execution of strategic initiatives across functions, ensuring alignment and standardization. Collaborate with leadership to drive performance visibility and enhance communication, fostering a...
1 week ago
$109K - $129K *
Take ownership of product development in a dynamic, cross-functional team. Drive AI-assisted innovation from problem framing to launch, focusing on customer outcomes and strategic impact in a hyper-ag...
1 week ago
$85K - $115K *
Shape user-centric digital experiences by collaborating with cross-functional teams to design intuitive products that enhance participant engagement and operational workflows. Drive design from concep...
1 week ago
Associate General Counsel, Ads Product
$266K - $372K *
Join a dynamic Ads Legal team to provide strategic legal guidance on product initiatives, ensuring compliance with evolving regulations while collaborating across functions to drive innovation in a fa...
1 week ago
$135K - $151K *
Drive product strategy and execution for Patient Experience solutions, enhancing healthcare practices' connection with patients. Lead cross-functional teams, leverage AI, and optimize workflows to imp...
1 week ago
Sr/Staff Frontend Engineer | Web Products
$200K - $250K *
Drive impactful frontend solutions, transforming complex requirements into user-centric, performant interfaces. Collaborate closely with cross-functional teams to enhance the healthcare experience for...
Reposted 1 week ago
Senior/Staff Full Stack Software Engineer
$180K - $240K *
Build innovative software solutions for federal partners, focusing on full-stack development, user experience, and secure integrations. Collaborate with cross-functional teams to deliver impactful app...
1 week ago
Software Engineer (PDLC Tooling + Automation)
$100K - $167K *
Drive efficiency at the intersection of product development and customer engagement by building integrations and automations that empower teams with timely, relevant product knowledge and streamline w...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.