Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$148K - $274K *

Partner with us to navigate complex regulatory environments, ensuring compliance and facilitating business expansions. Leverage your expertise to advise leadership and manage licensure processes effec...

Missouri, USRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$87K - $157K *

Manage strategic programs and complex projects, ensuring timely delivery while effectively leading cross-functional teams to achieve key business objectives and drive organizational success...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$87K - $161K *

Lead the charge in managing a clinical review team to ensure optimal member care through effective utilization management and compliance with healthcare standards. Drive improvements and foster commun...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$102K - $190K *

Innovate data management processes by leading the development of robust data pipelines, ensuring high-quality data for analytics and reporting. Collaborate with cross-functional teams to enhance data...

Missouri, USRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $126K *

Drive impactful digital content development through Salesforce Marketing Cloud, managing cross-functional communication strategies to enhance member engagement and optimize performance metrics for eff...

Missouri, USRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $126K *

Transform member engagement by developing digital content through Salesforce Marketing Cloud. Collaborate across teams to manage communication strategies, analyze performance metrics, and enhance user...

Missouri, USRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$171K - $326K *

Strategize product development and market opportunities while collaborating across teams to innovate ACA/Marketplace offerings that meet client needs and drive growth...

Missouri, USRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$93K - $140K *

Manage customer relationships and drive agronomy solutions by leveraging technical expertise. Collaborate with sales teams to enhance product positioning and execute training, while creating new marke...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$107K - $161K *

Drive local seed sales success by training teams, developing agronomy tools, and assessing market needs. Collaborate with sales and agronomy experts to enhance product strategies and execute effective...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$123K - $185K *

Lead K-12 sales initiatives in the Southeast, driving growth through strategic partnerships and culinary collaborations while enhancing product placements and bid success across school districts...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$94K - $164K *

Drive business continuity and disaster recovery initiatives, ensuring critical operations are sustained and services restored post-disruption. Collaborate with stakeholders to assess risks, validate r...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$62K - $100K *

Join a team that's dedicated to delivering successful projects by managing small complexity initiatives, ensuring milestones are met, and fostering collaboration across business and IT stakeholders fo...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $115K *

Transform the future of digital products by managing their lifecycle, optimizing user experiences, and collaborating with cross-functional teams to drive engagement and adoption while ensuring alignme...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $164K *

Elevate project outcomes by managing medium to high complexity initiatives, ensuring timely delivery, stakeholder engagement, and adherence to best practices throughout the project lifecycle...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $132K *

Champion operational excellence by leading compliance and process improvements in Utilization Management. Collaborate across teams to identify gaps, drive change, and ensure adherence to regulatory st...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Empower your career as a Principal IAM Engineer, owning the identity control plane and ensuring secure access to sensitive data. Collaborate with cross-functional teams to automate identity processes...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Join a dynamic team to advance analytical chemistry methods and lead projects. Utilize your expertise in LC-MS for bioanalytical applications while mentoring junior scientists and driving innovation i...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead the execution of strategic initiatives across functions, ensuring alignment and standardization. Collaborate with leadership to drive performance visibility and enhance communication, fostering a...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$109K - $129K *

Take ownership of product development in a dynamic, cross-functional team. Drive AI-assisted innovation from problem framing to launch, focusing on customer outcomes and strategic impact in a hyper-ag...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $115K *

Shape user-centric digital experiences by collaborating with cross-functional teams to design intuitive products that enhance participant engagement and operational workflows. Drive design from concep...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$266K - $372K *

Join a dynamic Ads Legal team to provide strategic legal guidance on product initiatives, ensuring compliance with evolving regulations while collaborating across functions to drive innovation in a fa...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$135K - $151K *

Drive product strategy and execution for Patient Experience solutions, enhancing healthcare practices' connection with patients. Lead cross-functional teams, leverage AI, and optimize workflows to imp...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $250K *

Drive impactful frontend solutions, transforming complex requirements into user-centric, performant interfaces. Collaborate closely with cross-functional teams to enhance the healthcare experience for...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$180K - $240K *

Build innovative software solutions for federal partners, focusing on full-stack development, user experience, and secure integrations. Collaborate with cross-functional teams to deliver impactful app...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $167K *

Drive efficiency at the intersection of product development and customer engagement by building integrations and automations that empower teams with timely, relevant product knowledge and streamline w...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.