Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$95K - $115K *
Elevate your career by leading cross-functional teams to deliver innovative technology solutions. Drive performance, ensure data integrity, and foster collaboration while aligning with organizational...
1 week ago
Client Accounting Division Manager
$120K - $140K *
Lead the charge in managing a self-contained accounting division, driving performance across KPIs while fostering team growth and client relationships. This hands-on role requires expertise in invento...
1 week ago
$250K - $300K *
Empower the future of AI in commerce media by leading strategy and execution across AI Labs and Data Science. Drive customer engagement, scale capabilities, and enhance product impact while building a...
Reposted 1 week ago
Protective Intelligence and Investigations Lead
$125K - $150K *
Shape the future of protective intelligence by building and owning a comprehensive program that integrates threat assessments, investigations, and operational processes, ensuring security while enabli...
1 week ago
Forward Deployed Engineer (Fort Lauderdale/Miami)
$110K - $130K *
Drive impactful solutions as a Forward Deployed Engineer, collaborating with clients to tackle complex challenges. Design and deploy AI-enabled applications, ensuring reliability and performance in re...
Reposted 1 week ago
Senior Manager, Asset Quality & Model Oversight
$172K - $238K *
Champion asset quality and model oversight in secured lending. Lead a team to monitor portfolio performance, ensure compliance, and mitigate risks across home equity and auto lending channels, driving...
1 week ago
$74K - $87K *
Transform client implementations by leading discovery, planning, and execution. Own project scope, timelines, and budgets to ensure successful adoption of solutions that align with business goals and...
1 week ago
Supervisor, Medical Review Audit (Clinical)
$80K - $95K *
Transform your career by leading a remote team of clinical auditors in Skilled Nursing Facility audits. Drive performance, ensure compliance, and enhance staff development while overseeing quality and...
1 week ago
Senior Product Manager II (Growth & Traffic)
$150K - $190K *
Accelerate user growth by leading cross-functional teams to optimize traffic acquisition strategies. Collaborate with marketing and engineering to drive impactful experiments and achieve business goal...
1 week ago
Senior Manager Strategic Sourcing
$110K - $130K *
Join our team as you lead the development and execution of a comprehensive transportation procurement strategy, ensuring excellence in service and cost optimization across a $100M+ budget...
Reposted 1 week ago
EHRM Operations Support Analyst (Remote Opportunity)
$80K - $95K *
Join a supportive team to enhance healthcare operations through HL7 interface monitoring, troubleshooting integration issues, and assisting with deployments in a remote environment, while ensuring sys...
Reposted 1 week ago
Account Executive - In-Territory (Dallas, TX)
$85K - $103K *
The Account Executive in-territory for Justworks in Dallas is responsible for managing the full sales cycle, from prospecting to closing deals, while building relationships within the small business c...
Reposted 1 week ago
Senior DevOps Engineer (Active Secret Clearance)
$185K - $230K *
Advance your career by ensuring seamless performance of AI systems in diverse environments. Collaborate with customers and teams, automating and maintaining infrastructure for reliability across uncla...
Reposted 1 week ago
$110K - $130K *
Join a team that's redefining automation in industrial testing. You'll develop robust test frameworks and simulators, ensuring seamless integration and coverage for critical protocols while collaborat...
1 week ago
Solutions Engineer | East Coast | Remote
$182K - $226K *
Innovate with a dynamic team to solve customer challenges and drive growth. Leverage your technical expertise in pre-sales to enhance customer engagement and deliver impactful solutions in a fast-pace...
1 week ago
$188K - $276K *
Join a team that's redefining customer onboarding and compliance through innovative product management. Drive strategy, lead cross-functional teams, and enhance user experiences while ensuring top-tie...
1 week ago
$127K - $168K *
Join a team that thrives on building enduring relationships and delivering tailored financial strategies to high-net-worth clients. Drive new business opportunities while collaborating with experts to...
Reposted 1 week ago
Data Center Substation, Protection & Automation Engineer
$320K - $405K *
Engineer cutting-edge protection and automation systems for high-voltage substations, ensuring reliable power distribution and integration across our infrastructure portfolio. Collaborate with teams t...
1 week ago
$71K - $90K *
Shape support operations by optimizing tools and processes, aligning teams, and driving initiatives that elevate the customer experience while ensuring efficient operations and effective reporting for...
Reposted 1 week ago
$100K - $120K *
Unlock new business opportunities by driving sales in small specialty practices. Lead consultative sales cycles, build relationships, and deliver tailored solutions that enhance operational efficiency...
1 week ago
Sr. Revenue Enablement Manager, Partnerships & Supply
$115K - $160K *
Join us to empower our partner and supply teams through innovative enablement programs. You'll design training, manage resources, and leverage AI to enhance performance and drive growth in our lodging...
1 week ago
Senior Site Reliability Engineer - FedRAMP
$140K - $185K *
Oversee cloud operations in a FedRAMP environment, ensuring security, reliability, and scalability. Lead the design, building, and management of complex infrastructure projects while optimizing perfor...
Reposted 1 week ago
$134K - $265K *
Join a dynamic SAP team to lead Revenue Accounting and Reporting solutions, guiding clients through the entire lifecycle from design to deployment. Drive innovation and compliance while mentoring team...
1 week ago
$134K - $265K *
Unlock potential by leading SAP Revenue Accounting and Reporting initiatives, guiding clients through the entire solution lifecycle, from design to deployment, while ensuring compliance with ASC 606 a...
1 week ago
HPC AI Solution Architect (S2S)
$141K - $278K *
Lead the charge in designing and implementing cutting-edge GPU-accelerated AI infrastructures. Collaborate with cross-functional teams to drive impactful technology solutions while engaging with C-sui...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.