Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Elevate your career by leading cross-functional teams to deliver innovative technology solutions. Drive performance, ensure data integrity, and foster collaboration while aligning with organizational...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $140K *

Lead the charge in managing a self-contained accounting division, driving performance across KPIs while fostering team growth and client relationships. This hands-on role requires expertise in invento...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$250K - $300K *

Empower the future of AI in commerce media by leading strategy and execution across AI Labs and Data Science. Drive customer engagement, scale capabilities, and enhance product impact while building a...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $150K *

Shape the future of protective intelligence by building and owning a comprehensive program that integrates threat assessments, investigations, and operational processes, ensuring security while enabli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Drive impactful solutions as a Forward Deployed Engineer, collaborating with clients to tackle complex challenges. Design and deploy AI-enabled applications, ensuring reliability and performance in re...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$172K - $238K *

Champion asset quality and model oversight in secured lending. Lead a team to monitor portfolio performance, ensure compliance, and mitigate risks across home equity and auto lending channels, driving...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$74K - $87K *

Transform client implementations by leading discovery, planning, and execution. Own project scope, timelines, and budgets to ensure successful adoption of solutions that align with business goals and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Transform your career by leading a remote team of clinical auditors in Skilled Nursing Facility audits. Drive performance, ensure compliance, and enhance staff development while overseeing quality and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $190K *

Accelerate user growth by leading cross-functional teams to optimize traffic acquisition strategies. Collaborate with marketing and engineering to drive impactful experiments and achieve business goal...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Join our team as you lead the development and execution of a comprehensive transportation procurement strategy, ensuring excellence in service and cost optimization across a $100M+ budget...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$80K - $95K *

Join a supportive team to enhance healthcare operations through HL7 interface monitoring, troubleshooting integration issues, and assisting with deployments in a remote environment, while ensuring sys...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $103K *

The Account Executive in-territory for Justworks in Dallas is responsible for managing the full sales cycle, from prospecting to closing deals, while building relationships within the small business c...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$185K - $230K *

Advance your career by ensuring seamless performance of AI systems in diverse environments. Collaborate with customers and teams, automating and maintaining infrastructure for reliability across uncla...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's redefining automation in industrial testing. You'll develop robust test frameworks and simulators, ensuring seamless integration and coverage for critical protocols while collaborat...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$182K - $226K *

Innovate with a dynamic team to solve customer challenges and drive growth. Leverage your technical expertise in pre-sales to enhance customer engagement and deliver impactful solutions in a fast-pace...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$188K - $276K *

Join a team that's redefining customer onboarding and compliance through innovative product management. Drive strategy, lead cross-functional teams, and enhance user experiences while ensuring top-tie...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Transportation

$127K - $168K *

Join a team that thrives on building enduring relationships and delivering tailored financial strategies to high-net-worth clients. Drive new business opportunities while collaborating with experts to...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$320K - $405K *

Engineer cutting-edge protection and automation systems for high-voltage substations, ensuring reliable power distribution and integration across our infrastructure portfolio. Collaborate with teams t...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$71K - $90K *

Shape support operations by optimizing tools and processes, aligning teams, and driving initiatives that elevate the customer experience while ensuring efficient operations and effective reporting for...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Technical Services

$100K - $120K *

Unlock new business opportunities by driving sales in small specialty practices. Lead consultative sales cycles, build relationships, and deliver tailored solutions that enhance operational efficiency...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $160K *

Join us to empower our partner and supply teams through innovative enablement programs. You'll design training, manage resources, and leverage AI to enhance performance and drive growth in our lodging...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $185K *

Oversee cloud operations in a FedRAMP environment, ensuring security, reliability, and scalability. Lead the design, building, and management of complex infrastructure projects while optimizing perfor...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$134K - $265K *

Join a dynamic SAP team to lead Revenue Accounting and Reporting solutions, guiding clients through the entire lifecycle from design to deployment. Drive innovation and compliance while mentoring team...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$134K - $265K *

Unlock potential by leading SAP Revenue Accounting and Reporting initiatives, guiding clients through the entire solution lifecycle, from design to deployment, while ensuring compliance with ASC 606 a...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$141K - $278K *

Lead the charge in designing and implementing cutting-edge GPU-accelerated AI infrastructures. Collaborate with cross-functional teams to drive impactful technology solutions while engaging with C-sui...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.