Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$90K - $110K *

Join a team that's dedicated to enhancing HR data integration. Leverage your Workday expertise to design, implement, and maintain seamless connections between systems, ensuring data integrity and perf...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$60K - $120K *

Accelerate customer success by driving upgrades and expanding product use. In this full-cycle sales role, you'll engage with existing clients, identify opportunities, and close deals to enhance their...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Champion strategic initiatives by leading account management and operational excellence. Drive program deployment, enhance client relationships, and ensure team performance to exceed expectations whil...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$75K - $95K *

Unlock potential by coaching a nationwide team of salespeople in consultative selling. Leverage your B2B sales expertise to enhance their skills, drive accountability, and foster strong referral relat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$150K - $180K *

Reimagine the consumer landscape by leading strategy and performance for a dynamic business across North America. Drive growth, enhance customer experience, and influence global teams to deliver excep...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Shape the future of security compliance by leading SOC 2, ISO 27001, and ISO 27701 programs. Drive governance, internal audits, and automation to ensure compliance evolves with business growth while m...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$91K - $121K *

Optimize the commercialization process by owning end-to-end management, collaborating across functions, and leveraging AI tools to enhance efficiency and scalability, ultimately driving data integrity...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $140K *

Transform user experiences by building and enhancing robust software solutions across frontend and backend layers, focusing on customer-facing AI products to ensure quality and safety in delivery...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $220K *

Drive the end-to-end ML and LLM lifecycle, optimizing AI workflows and automations. Collaborate with cross-functional teams to ensure scalable, reliable production of AI-driven solutions while impleme...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Join a team that's redefining growth through innovative design. Collaborate across functions to create impactful user experiences that drive client acquisition and engagement, shaping the future of fi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$132K - $165K *

Join a team that's dedicated to enhancing partner relationships and driving strategic initiatives. Utilize your project management skills to support account growth and ensure partner satisfaction in a...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $130K *

Shape the future of pharmacy benefits by managing key client relationships, ensuring operational excellence, and driving satisfaction through effective communication and problem-solving in a dynamic P...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $105K *

Oversee facility maintenance operations, ensuring compliance with safety standards and efficient management of resources. Lead a team to maintain a safe, sanitary environment while coordinating projec...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$66K - $93K *

Champion infection prevention excellence by leading a comprehensive program, ensuring compliance, and collaborating with healthcare teams to enhance patient safety and care quality across the facility...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$200K - $270K *

Shape the future of immunotherapy by leading access strategies for a groundbreaking T-cell therapy. Collaborate with cross-functional teams to ensure timely payer engagement and coverage decisions, ma...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Engage with cross-functional teams to design and optimize financial databases and reporting solutions, ensuring data integrity and supporting critical business decisions through high-performance data...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$238K - $280K *

Shape the future of AI/LLM security by leading innovative offensive strategies, defining technical vision, and driving cross-company initiatives to enhance NodeZero's capabilities in identifying and e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$93K - $137K *

Join a dynamic team to enhance partner relationships, drive operational excellence, and foster business growth through strategic onboarding and support initiatives. Leverage your insurance expertise t...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$78K - $100K *

Lead the end-to-end program management for enterprise clients in financial services, driving alignment and execution across cross-functional teams to achieve measurable business outcomes and ensure se...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$138K - $165K *

Champion the development of LLM-powered applications and agentic systems. Drive complex use cases from ambiguous problems to production, ensuring high-quality and scalable AI solutions that address us...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$236K - $325K *

Lead the charge in global security investigations and incident response, guiding complex incidents while building operational practices and technical capabilities to ensure effective responses across...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $150K *

Drive underwriting excellence by managing property risks and building strong broker relationships. Collaborate with a dynamic team to deliver innovative solutions in a fully remote environment, focusi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K *

Drive innovation in healthcare technology by leading product management efforts, connecting cross-functional teams, and shaping the product roadmap to enhance value-based care solutions. Engage hands...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Join us to design and develop cutting-edge enterprise software solutions using Java, Python, and AI technologies. Collaborate in a dynamic environment that values innovation and technical excellence w...

1 week ago

  •   5 - 7 years exp.  •   Staffing

$88K - $105K *

Empower innovation in analytical chemistry by developing LC-MS methods, mentoring junior scientists, and enhancing lab operations. Drive project success through method validation and troubleshooting i...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.