Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$97K - $174K *

Champion patient care in Breast Medical Oncology, providing comprehensive support throughout the cancer journey. Collaborate with a multidisciplinary team to develop treatment plans and enhance patien...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$180K - $324K *

Join a team that's expanding its anesthesia practice, providing diverse care across multiple facilities. Collaborate with skilled professionals in a dynamic environment, delivering high-quality anesth...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Drive impactful presale messaging and project management by collaborating with cross-functional teams to craft compelling presentations that resonate with clients and showcase our unique value proposi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$106K - $127K *

Empower finance teams by bridging systems and analysis, enhancing budgeting, forecasting, and reporting processes. Collaborate with stakeholders to translate needs into effective solutions, driving im...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$76K - $105K *

Lead the charge in optimizing and supporting application implementations, conducting needs assessments, and managing projects to enhance business processes and user experience for healthcare applicati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Deliver comprehensive primary and specialty care as an Advanced Practice Provider, collaborating with a healthcare team to enhance patient outcomes. Emphasize health promotion and disease prevention w...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Transform legal practices by overseeing medical malpractice litigation, guiding internal teams, and collaborating with business partners. Leverage your expertise to ensure compliance and provide strat...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $115K *

Engage with customers to ensure successful onboarding and implementation of solutions. Collaborate across teams to drive value, manage projects, and advocate for customer needs while building trusted...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$265K - $295K *

Unlock potential by leading a global Customer Success team, driving client satisfaction, renewals, and growth in the Wellbeing division. Collaborate with executives to shape strategy and enhance clien...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $140K *

Transform customer relationships and drive growth by identifying upsell opportunities and ensuring satisfaction within our Health and Wellness vertical. Collaborate with teams to advocate for clients...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Lead and develop a high-performing project management team, ensuring operational excellence and customer satisfaction while driving regional business performance through effective project execution an...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Shape the future of consumer litigation by managing complex cases, providing strategic legal guidance, and collaborating with cross-functional teams to achieve effective resolutions while mitigating r...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Engage with executive buyers to drive new business in retail, leveraging AI solutions. Build trusted relationships, manage complex sales processes, and ensure smooth transitions to post-sale teams whi...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$150K - $180K *

Unlock potential by driving new business with large enterprises, building trusted relationships with executive buyers, and guiding complex sales from discovery to close, while collaborating across tea...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$80K - $150K *

Unlock potential by connecting with experienced Employee Benefits professionals for future Senior Account Manager and Account Executive roles, focusing on client management, service excellence, and bu...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$105K - $125K *

Lead and oversee Account Management teams, ensuring operational excellence and compliance while fostering staff development and enhancing client relationships in a dynamic remote environment...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $150K *

Join a team that's shaping the future of commercial insurance by leveraging your expertise in account management and client relations. Collaborate with industry professionals to drive service excellen...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Unlock potential by providing expert legal guidance in government contracting, ensuring compliance and strategic negotiation. Collaborate with stakeholders to navigate complex contracts while safeguar...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $180K *

Advance our user-centric product vision by leading design and research initiatives. Collaborate with cross-functional teams to integrate AI and enhance learning experiences, ensuring alignment with st...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$67K - $101K *

Contribute to impactful education by mentoring doctoral students and enhancing curriculum. Engage in teaching, governance, and professional service while fostering inclusive learning environments and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $104K *

Drive the full lifecycle of contractual agreements, ensuring compliance and efficiency while collaborating across teams to enhance processes and support organizational goals in a dynamic, remote-frien...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$63K - $111K *

Join a team that's dedicated to enhancing security systems globally. As a Senior Security Technician, you'll install, maintain, and troubleshoot advanced security solutions while mentoring junior staf...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$74K - $130K *

Elevate operational efficiency by providing project coordination and logistical support. Collaborate with stakeholders to enhance business continuity, risk management, and process analysis while devel...

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$99K - $232K *

Champion finance transformation by leading digital revenue operations, enhancing client revenue processes through analysis, implementation, and support while mentoring teams and managing multiple work...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$124K - $280K *

Lead transformative SAP Order to Cash projects, enhancing customer processes and driving effective software adoption while guiding diverse teams through complex challenges and delivering impactful sol...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.