Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$90K - $130K *

Drive exceptional client experiences by leading client services strategy and operations across screening services. Empower teams to deliver timely, accurate support while fostering a culture of accoun...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Empower data-driven decisions by designing and optimizing complex data pipelines. Collaborate with cross-functional teams to ensure scalable, high-quality data solutions that enhance analytics and rep...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Unlock potential by driving impactful marketing strategies for a key partnership. Collaborate across teams to create campaigns, manage events, and analyze performance, directly influencing revenue gro...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$170K - $210K *

Join a dynamic team to develop transformative brand strategies that inspire clients and drive impactful campaigns. Collaborate across functions to deliver insights and solutions that elevate brand per...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Join a team that's redefining client success in the pharma sector by leading strategic initiatives, fostering senior-level relationships, and driving innovative marketing solutions for key accounts wh...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$102K - $135K *

Lead the charge in overseeing construction projects, ensuring safety, quality, and timely completion while collaborating with teams and managing subcontractors to achieve project goals effectively...

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$163K - $237K *

Lead the charge in shaping advertising agreements for a dynamic legal team. Collaborate across functions to drive growth in our ad tech initiatives while ensuring compliance and efficiency in a fast-p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$131K - $240K *

Shape the future of training and development in orthopedic medical devices, enhancing sales effectiveness and fostering strong partnerships across teams. Drive learning initiatives and support surgica...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$201K - $251K *

Engage with Key Opinion Leaders to drive strategic marketing initiatives, leveraging clinical expertise to influence oncologists and enhance brand strategy. Collaborate cross-functionally to execute i...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Grow your career with a nationally recognized team providing advanced practice nursing for pediatric patients. Engage in evidence-based care while developing leadership skills under the mentorship of...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Lead comprehensive evaluations of federally subsidized housing, ensuring compliance with safety and accessibility standards. Collaborate with inspectors to enhance operational performance and resolve...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$125K - $150K *

Champion quality assurance for outsourced drug manufacturing, ensuring compliance and readiness for commercial launch. Lead a dynamic team, collaborating with cross-functional partners to build scalab...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $150K *

Drive excellence by executing full-scope IT audits, ensuring compliance with federal standards, and enhancing system security. Collaborate with stakeholders to assess controls and recommend improvemen...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$81K - $106K *

Champion innovative pet food product development by leveraging your expertise in formulation and engineering. Collaborate with cross-functional teams to enhance product performance and drive quality i...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$130K - $225K *

Join a team that's pioneering AI capabilities by designing, building, and deploying production-ready AI solutions. Collaborate with cross-functional teams to integrate advanced technologies into a sec...

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$85K - $90K *

Drive impactful analytics solutions by leading customer engagement workstreams, optimizing digital communications, and mentoring junior analysts. Leverage data to enhance government program performanc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$230K - $398K *

Join us in shaping the future of healthcare technology as a strategic leader driving digital transformation, overseeing enterprise IT operations, and enhancing patient care through innovative solution...

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$63K - $104K *

Join a team that's dedicated to enhancing patient care through expert nutrition assessments and interventions. Collaborate with healthcare professionals to provide individualized nutrition education a...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$84K - $115K *

Shape the future of employee financial wellbeing by leading retirement programs, ensuring compliance, and driving strategic initiatives that enhance retirement readiness and financial security for all...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$240K - $270K *

Join a team that's driving enterprise growth by owning relationships and closing deals. Leverage your expertise to navigate complex sales cycles, build a self-sourced pipeline, and expand accounts whi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$181K - $214K *

Lead the charge in defining and executing on-platform measurement strategies, ensuring effective ad performance tracking and reporting across diverse ad formats while collaborating with engineering an...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Technical Services

$125K - $150K *

Lead the charge in optimizing enrollment and fulfillment operations, ensuring timely service delivery and high-quality support for residents and Property Management Companies. Drive process improvemen...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$159K - $254K *

Drive impactful software development to enhance customer delivery experiences. Collaborate with cross-functional teams to design resilient systems that support real-time order tracking and efficient p...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's dedicated to enhancing patient care through innovative pharmacy practices. Collaborate with healthcare professionals in a dynamic environment, ensuring optimal medication management...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Champion the commercial contracting process by drafting, reviewing, and negotiating agreements. Collaborate with cross-functional teams to streamline workflows and ensure compliance while supporting t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.