Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Account Manager, Life Sciences
$110K - $130K *
Join a dynamic team to drive growth and retention for strategic enterprise customers. Leverage your expertise in technology solutions to build relationships, develop account strategies, and ensure cus...
1 week ago
Field Service Technician (St. Louis, MO)
$74K - $86K *
Support our commitment to service excellence by conducting preventive maintenance and repairs on equipment. Collaborate with customers to address concerns and ensure satisfaction while following safet...
Reposted 1 week ago
First Officer (Home Based) - G-IV or G450
$112K *
Take ownership of premium flight operations as a First Officer, delivering exceptional service and safety while fostering career growth through advanced training and leadership opportunities within a...
Reposted 1 week ago
Senior Manager, Machine Learning Engineering
$230K - $290K *
Lead the charge in optimizing ad performance through innovative algorithms and machine learning. Collaborate with cross-functional teams to enhance advertising effectiveness and drive business success...
1 week ago
Senior Manager, Programmatic B2B
$84K - $100K *
Drive the growth of B2B programmatic practices, overseeing campaign operations, client relationships, and strategy development while ensuring campaign excellence across multiple platforms and stakehol...
Reposted 1 week ago
$93K - $120K *
Transform the leave of absence experience by overseeing compliance, managing vendor relationships, and implementing strategic improvements. Collaborate with HR and leadership to ensure seamless proces...
Reposted 1 week ago
Coder III - Radiation Oncology - Remote - 141725
$78K - $103K *
Join a dynamic team to perform complex coding reviews in Radiation Oncology. Leverage your expertise in CPT, HCPCS, and ICD-10 to resolve errors and ensure accurate billing. This remote role offers a...
Reposted 1 week ago
$73K - $102K *
Advance your career by leading full-stack Java development projects, leveraging cloud technologies and DevOps practices to deliver innovative solutions. Collaborate with cross-functional teams to driv...
1 week ago
Registered Nurse (Renal Nurse Manager)
$80K - $95K *
Empower healthcare excellence by leading a dedicated nursing team, ensuring high-quality patient care, and fostering professional development in a dynamic clinic environment. Drive initiatives that en...
1 week ago
Senior Software Engineer, Backend (AI Platform)
$173K - $255K *
Drive innovation in AI systems by designing and building scalable backend solutions, ensuring security and governance while enhancing developer productivity and operational health across diverse workl...
Reposted 1 week ago
Clinical Applications Consultant - Transfusion/Blood Bank - Missouri Territoy
$90K - $120K *
Empower customer satisfaction by providing expert installation, training, and ongoing support for clinical analyzers. Collaborate with stakeholders to ensure compliance and enhance service delivery ac...
1 week ago
Enterprise Customer Success Manager
$95K - $115K *
Drive customer success by building strong relationships with enterprise accounts, ensuring strategic guidance, adoption, and retention. Collaborate cross-functionally to enhance customer experiences a...
1 week ago
Director, Field People Business Partner (Northeast)
$125K - $190K *
Lead the regional People strategy, partnering with executives to drive workforce planning, talent management, and organizational effectiveness while ensuring consistent execution of People programs ac...
1 week ago
Senior Engineering Manager, Borrower Experience
$195K - $270K *
Elevate borrower experiences by leading a fullstack engineering team to create intuitive, reliable web and mobile solutions. Shape technical strategy and modernize architecture while fostering collabo...
1 week ago
$130K - $150K *
Shape the future of healthcare quality assurance by leading a dynamic team focused on DRG validation. Drive training, audits, and process improvements to enhance clinical accuracy and operational effi...
1 week ago
Senior Director, Complex Systems
$184K - $230K *
Lead the Complex Systems portfolio to enhance climate impact, ensuring cohesive strategy and program effectiveness across Land, Transportation, and Industry while aligning resources for sustainable so...
Reposted 1 week ago
Management Consultant - Data Engineer
$147K - $275K *
Drive data-driven strategies by analyzing complex datasets and providing actionable insights. Collaborate with cross-functional teams to enhance decision-making processes and optimize business perform...
1 week ago
$80K - $95K *
Join a team that's dedicated to enhancing housing standards through comprehensive inspections and evaluations of federally subsidized properties, ensuring compliance with safety regulations and improv...
1 week ago
$140K - $150K *
Lead the charge in ensuring top-notch quality across health tech products. Oversee QA execution, mentor junior testers, and collaborate with cross-functional teams to deliver high-quality software tha...
1 week ago
Senior Electrical Engineer (USA)
$120K - $145K *
Empower your career as a Senior Electrical Engineer, leading cutting-edge designs for high-capacity data centers, while collaborating with top industry professionals on impactful, mission-critical pro...
Reposted 1 week ago
$138K - $190K *
Advance solutions in behavioral health by leveraging technical expertise to drive sales success. Collaborate with teams to deliver tailored demonstrations, support RFPs, and align strategies with clie...
1 week ago
Supervisory Emergency Management Specialist (Planning Unit Leader)
$90K - $107K *
Transform emergency management operations by leading planning efforts for disaster response. Collaborate with diverse stakeholders to enhance program delivery and ensure effective communication during...
1 week ago
Regional Sales Manager - Industrial
$90K - $110K *
Grow your career with a dynamic sales role focused on driving growth in industrial manufacturing. Engage with customers, manage the sales process, and achieve targets while building lasting relationsh...
1 week ago
Senior Architect - Data Platforms & Architecture
$145K - $175K *
Lead the charge in architecting scalable Azure solutions across multi-team programs, aligning client goals with innovative designs. Mentor teams, drive modernization efforts, and ensure high-quality d...
1 week ago
$120K - $140K *
Engineer key aspects of a native iOS app, enhancing user experiences and maintaining robust code. Collaborate cross-functionally to drive performance, scalability, and code quality while iterating on...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.