Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$120K - $140K *

Accelerate progress at the forefront of specialty care, delivering impactful Pulmonology services. Collaborate with interdisciplinary teams to provide high-quality, patient-centered care in skilled nu...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$93K - $125K *

Lead the charge in managing integrated logistics efforts across military programs, guiding a team of specialists in delivering projects on schedule and within budget while ensuring regulatory complian...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$115K - $165K *

Join our team to provide advanced support as a Senior Network Engineer, overseeing complex issues across multiple technologies and enhancing network performance for diverse client environments. Drive...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$88K - $105K *

Oversee project delivery from preconstruction to closeout, ensuring compliance, safety, and quality in healthcare environments. Build strong relationships with stakeholders while managing budgets, sch...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Drive the successful delivery of complex industrial construction projects, ensuring alignment with budget, schedule, and safety standards while fostering strong client relationships and mentoring proj...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$135K - $150K *

Join a team that's redefining partner marketing in the AI space. Drive strategic initiatives, enhance collaboration, and elevate brand presence through innovative co-marketing efforts, ensuring impact...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Lead tax strategy and compliance for a multi-entity healthcare business, driving growth and managing risk. Build and scale the tax function while overseeing audits, planning, and team development to s...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$85K - $95K *

Partner with us to deliver tailored solutions and technical expertise, enhancing customer engagement through product demonstrations and RFP management while collaborating across teams to drive innovat...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$270K - $330K *

Help us drive enterprise growth by owning relationships and closing deals. You'll manage a greenfield territory, navigate complex sales cycles, and build a self-sourced pipeline while positioning our...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Lead the charge in patient care management by coordinating multidisciplinary teams, overseeing staff development, and ensuring quality performance in a dynamic healthcare environment...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$182K - $325K *

Empower the GTM AI Engineering team by building innovative AI solutions that enhance sales and customer success workflows. Lead strategy and hands-on development, ensuring reliable, impactful AI produ...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Advance high-quality hospice care by overseeing clinical operations, ensuring compliance, and fostering teamwork. Lead a dedicated team to enhance patient services while managing resources effectively...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$86K - $107K *

Lead advanced analytics projects that drive strategic decisions, optimize sales productivity, and enhance operational efficiency. Collaborate with executives to deliver data-driven insights and implem...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$180K - $225K *

Drive strategic growth by acquiring new clients and expanding market presence in data center and rapid deployment sectors. Lead complex business development initiatives, fostering executive relationsh...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $115K *

Help us drive client success by managing digital brand strategies and fostering strong relationships. Leverage your expertise in pharmaceutical marketing to deliver innovative solutions and ensure pro...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead a team of engineers to deliver innovative manufacturing solutions, manage resources and budgets, and ensure project timelines are met while fostering team development and stakeholder communicatio...

6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$130K - $145K *

Elevate public health data interoperability by designing and implementing secure, scalable data pipelines. Collaborate with cross-functional teams to modernize legacy systems and ensure compliance, dr...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$165K - $180K *

Empower G&A operations by leading AI-driven transformations, enhancing workflows, and automating processes. Collaborate across teams to prototype solutions, ensuring efficiency and reliability in syst...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$99K - $131K *

Elevate decision-making by leading data-driven strategies that enhance performance and drive growth. Collaborate across teams to transform insights into actionable recommendations, optimizing Asset Pr...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$72K - $124K *

Join a team that's dedicated to maintaining and troubleshooting complex electrical power systems. Leverage your expertise in installation, testing, and customer training to ensure optimal performance...

6 days ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Join a team that's driving digital transformation by spearheading sales in Application Modernization Services, leveraging AI trends to cultivate strategic client relationships and optimize business gr...

RemoteRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Technical Services

$131K - $228K *

Empower innovation by developing and optimizing radar perception systems for autonomous agricultural technology. Collaborate across hardware and software to enhance sensor fusion and ensure robust per...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$88K - $128K *

Drive impactful actuarial analyses and modeling to enhance healthcare services, collaborating with teams to ensure accurate financial forecasting and decision support that shapes health program strate...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Transform project delivery by leading complex, multi-phase initiatives, ensuring timely completion within budget and quality standards. Collaborate with cross-functional teams and maintain accountabil...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$95K - $115K *

Lead the modernization of our Automated Rental Management System by developing and executing automated and manual test suites. Collaborate with cross-functional teams to enhance quality assurance prac...

6 days ago

  •   Less than 5 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.