Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$144K - $200K *

Unlock potential by managing end-to-end technical deployments of computer vision systems. Collaborate with clients in diverse environments to ensure seamless production operations and enhance system p...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Staffing

$175K - $250K *

Shape the cloud infrastructure for AI agents, ensuring secure, scalable solutions that enhance customer workflows. Lead architectural decisions, establish standards, and drive innovation in a dynamic...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Join a team that's dedicated to driving innovation and excellence. You'll oversee projects, collaborate with cross-functional teams, and contribute to strategic initiatives that enhance operational ef...

6 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$79K - $103K *

Join a team dedicated to overseeing the full lifecycle of government and commercial contracts. You'll manage negotiations, ensure compliance, and provide strategic guidance while fostering effective p...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$85K - $100K *

Elevate patient care by diagnosing and managing visual system disorders. Collaborate with a dedicated team to enhance patient experiences and drive practice growth while ensuring adherence to clinical...

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Champion exceptional primary eye care by delivering personalized patient experiences while collaborating with a supportive team. Enjoy the freedom to practice your way and grow your expertise in a com...

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$83K - $104K *

Engineer complex electrical systems for conventional generation projects. Collaborate with cross-functional teams to ensure safe, timely, and cost-effective project delivery while promoting a positive...

6 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$138K - $180K *

Shape the future of medical device development by driving project execution, collaboration, and innovation within a dynamic Research & Development team focused on enhancing healthcare outcomes and pat...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $116K *

Elevate store performance by leading teams, enhancing customer experiences, and driving operational excellence while fostering a culture of engagement and safety for pets and associates...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $200K *

Drive global demand generation strategies to transform market demand into a robust pipeline. Lead a data-driven team, optimize website performance, and enhance marketing-sourced revenue across regions...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$130K - $155K *

Champion the safety design and validation of our autonomous trucking system, ensuring rigorous functional safety standards are met across all engineering and operational teams. Drive impactful safety...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Transportation

$98K - $156K *

Drive impactful pharmacy strategies by leveraging actuarial expertise and data analytics. Collaborate across teams to transform insights into actionable strategies, enhancing profitability and perform...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$112K - $168K *

Shape the future of process automation by leading strategic initiatives, optimizing manufacturing performance, and enhancing operational excellence through technical expertise and collaboration with g...

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$127K - $237K *

Join a team that's driving digital transformation by enhancing products and services, managing strategic initiatives, and developing talent to achieve organizational goals while ensuring optimal perfo...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$131K - $151K *

Transform the technical service landscape by leading product evaluations, overseeing training, and managing support activities. Drive operational excellence while ensuring top-tier service for ophthal...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive operational excellence by leading continuous improvement initiatives, optimizing processes, and enhancing safety, quality, and customer satisfaction across multiple business units to achieve mea...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $175K *

Engineer and optimize enterprise platforms for diverse environments, ensuring seamless deployment and support. Collaborate with clients to enhance cybersecurity, compliance, and observability solution...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $175K *

Lead the deployment and maintenance of cloud systems, ensuring operational excellence and seamless integration of new technologies. Collaborate with teams to enhance system performance and reliability...

6 days ago

  •   5 - 7 years exp.  •   Staffing

$100K - $120K *

Lead the charge in driving sales growth and customer engagement by managing key accounts and project strategies. Collaborate with cross-functional teams to enhance product positioning and deliver exce...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Join a team that's driving sales growth and customer engagement in the chemical and energy sectors. This role focuses on managing key accounts, developing strategies, and collaborating with cross-func...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $110K *

Shape the future of UHNW marketing by developing strategic initiatives that empower advisor teams, enhance client engagement, and drive growth through innovative marketing solutions and cross-function...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in operational readiness and logistics strategies to enhance production efficiency. Drive continuous improvement initiatives while coordinating cross-functional teams to ensure seamles...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$69K - $104K *

Lead and enhance credentialing and payor enrollment operations, ensuring compliance and accuracy while supervising specialists and streamlining processes to improve provider readiness and operational...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$68K - $103K *

Unlock potential by driving process improvements to reduce clinical and technical denials. Collaborate with teams to analyze trends, implement best practices, and enhance workflows, ensuring complianc...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$115K - $165K *

Transform the future of higher education by leading product strategy and development. Engage with cross-functional teams to deliver impactful solutions while mentoring a team of Product Managers to dr...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.