Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$170K - $200K *

Drive exceptional anesthesia care in a modern outpatient setting while enjoying autonomy and a predictable schedule. Collaborate closely with a skilled team in a physician-led environment focused on h...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$170K - $200K *

Lead the charge in delivering exceptional anesthesia care for outpatient GI procedures, enjoying a high degree of autonomy without the demands of night, weekend, or holiday shifts. Join a supportive...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$114K - $221K *

Lead the charge in designing and implementing efficient data pipelines, ensuring data quality and integrity during cloud migration. Collaborate within Agile teams to optimize data processes and suppor...

Today

  •   5 - 7 years exp.  •   Business Services

$72K - $132K *

Accelerate progress at large SAP projects by developing, managing, and maintaining a comprehensive master schedule. Ensure clear communication and timely updates with clients and delivery teams while...

Reposted today

  •   Less than 5 years exp.  •   Business Services

$91K - $246K *

Unlock your potential by developing high-quality SAP ABAP solutions. Collaborate with cross-functional teams to translate business needs into technical designs, mentor junior developers, and drive mod...

Reposted today

  •   Less than 5 years exp.  •   Business Services

$182K - $250K *

Champion market development strategies to enhance our presence in CMS and HHS. Leverage your expertise to build relationships, identify opportunities, and drive impactful outcomes in federal health IT...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$154K - $185K *

Lead the charge in developing advanced AI systems and automation platforms. Own multi-agent architectures and backend services that optimize workflows across teams, driving operational efficiency and...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Inspire innovation by leading a data department to shape analytics strategies, manage operational delivery, and execute data initiatives that empower business decisions and drive growth across multipl...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$300K - $350K *

Lead the charge in driving enterprise revenue across the West territory, engaging with senior security leaders in regulated industries. Shape strategic sales initiatives and build lasting relationship...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$105K - $123K *

Innovate in security engineering by supporting IAM, AI, and Cloud initiatives. Leverage your IT or software development skills to enhance security practices while collaborating with senior engineers i...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$215K - $235K *

Lead the charge in building a robust partner ecosystem for defense contractors, driving revenue through MSSPs, MSPs, RPOs, and C3PAOs. Own partner recruitment, enablement, and success, while collabora...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform higher education through innovative Salesforce solutions, guiding institutions in architecture design, implementation, and best practices to enhance student engagement and operational effici...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Staffing

$130K - $160K *

Join a team that's dedicated to optimizing customer success through technical expertise. As a trusted advisor, you'll manage relationships, guide deployments, and ensure seamless adoption for federal...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Lead enterprise architecture strategy across Oracle CX, ERP, HCM, and SCM Cloud. Collaborate with stakeholders to develop scalable solutions, ensuring alignment with business capabilities and technolo...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Staffing

$125K - $150K *

Unlock potential by managing client relationships and driving project success. You'll proactively address issues, identify growth opportunities, and ensure delivery excellence while fostering strong p...

United StatesRemote

Reposted today

  •   15+ years exp.  •   Staffing

$95K - $115K *

Unlock your potential as a Data Engineer, driving innovative data solutions and optimizing data pipelines. Collaborate with cross-functional teams to enhance data quality and support analytics initiat...

Today

  •   5 - 7 years exp.  •   Information Technology

$92K - $136K *

Help us drive customer success by owning and optimizing digital engagement programs. You'll lead strategy, build automated journeys, and analyze performance to enhance customer experiences and ensure...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Empower innovation by designing intelligent AI agents and automation solutions. Collaborate with architects and stakeholders to implement cutting-edge Generative AI technologies for enterprise applica...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $150K *

Optimize complex Salesforce implementations by leading cross-functional teams, managing project lifecycles, and ensuring successful client outcomes through effective communication and risk management...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$80K - $90K *

Join a team that's dedicated to strategic program execution and risk mitigation. As a key analyst, you'll prepare and evaluate initiatives, collaborate across functions, and drive project success thro...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Staffing

$101K - $150K *

Analyze complex data sets to drive insights and recommendations, collaborating with technical teams to enhance analytical capabilities and support client objectives through innovative visualizations a...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$69K - $107K *

Champion client success by leveraging technical expertise to enhance platform value, optimize workflows, and drive measurable outcomes. Collaborate with cross-functional teams to deliver innovative so...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Join a team that's transforming multi-cloud infrastructure. As a Staff Software Engineer, you'll design and build a cohesive platform across AWS, GCP, and Azure, leading a multi-component system while...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$223K - $255K *

Shape the future of patient access through science and evidence. In this field-based role, engage with national and regional payers, providing medical leadership and insights to inform access decision...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead and develop a high-performing Applied AI team, driving the delivery of production AI systems while ensuring security, reliability, and operational excellence in healthcare applications...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.