Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$170K - $200K *
Drive exceptional anesthesia care in a modern outpatient setting while enjoying autonomy and a predictable schedule. Collaborate closely with a skilled team in a physician-led environment focused on h...
Reposted today
$170K - $200K *
Lead the charge in delivering exceptional anesthesia care for outpatient GI procedures, enjoying a high degree of autonomy without the demands of night, weekend, or holiday shifts. Join a supportive...
Reposted today
Data Engineer in St. Louis, MO
$114K - $221K *
Lead the charge in designing and implementing efficient data pipelines, ensuring data quality and integrity during cloud migration. Collaborate within Agile teams to optimize data processes and suppor...
Today
SAP Project Scheduler - 100% onsite in St. Louis, MO
$72K - $132K *
Accelerate progress at large SAP projects by developing, managing, and maintaining a comprehensive master schedule. Ensure clear communication and timely updates with clients and delivery teams while...
Reposted today
SAP ABAP Developer (100% onsite in St. Louis, MO)
$91K - $246K *
Unlock your potential by developing high-quality SAP ABAP solutions. Collaborate with cross-functional teams to translate business needs into technical designs, mentor junior developers, and drive mod...
Reposted today
Director, CMS & HHS Business Development
$182K - $250K *
Champion market development strategies to enhance our presence in CMS and HHS. Leverage your expertise to build relationships, identify opportunities, and drive impactful outcomes in federal health IT...
Reposted today
Staff AI Engineer | US | Remote
$154K - $185K *
Lead the charge in developing advanced AI systems and automation platforms. Own multi-agent architectures and backend services that optimize workflows across teams, driving operational efficiency and...
Reposted today
$150K - $180K *
Inspire innovation by leading a data department to shape analytics strategies, manage operational delivery, and execute data initiatives that empower business decisions and drive growth across multipl...
Reposted today
Account Executive, Commercial West
$300K - $350K *
Lead the charge in driving enterprise revenue across the West territory, engaging with senior security leaders in regulated industries. Shape strategic sales initiatives and build lasting relationship...
Reposted today
$105K - $123K *
Innovate in security engineering by supporting IAM, AI, and Cloud initiatives. Leverage your IT or software development skills to enhance security practices while collaborating with senior engineers i...
Today
Channel Account Manager, DIB/MSSP
$215K - $235K *
Lead the charge in building a robust partner ecosystem for defense contractors, driving revenue through MSSPs, MSPs, RPOs, and C3PAOs. Own partner recruitment, enablement, and success, while collabora...
Reposted today
Salesforce Higher Ed Solution Architect
$120K - $145K *
Transform higher education through innovative Salesforce solutions, guiding institutions in architecture design, implementation, and best practices to enhance student engagement and operational effici...
Reposted today
Technical Account Manager, Commercial
$130K - $160K *
Join a team that's dedicated to optimizing customer success through technical expertise. As a trusted advisor, you'll manage relationships, guide deployments, and ensure seamless adoption for federal...
Reposted today
Enterprise Architect - Oracle CX, ERP, HCM & SCM
$135K - $160K *
Lead enterprise architecture strategy across Oracle CX, ERP, HCM, and SCM Cloud. Collaborate with stakeholders to develop scalable solutions, ensuring alignment with business capabilities and technolo...
Reposted today
$125K - $150K *
Unlock potential by managing client relationships and driving project success. You'll proactively address issues, identify growth opportunities, and ensure delivery excellence while fostering strong p...
Reposted today
$95K - $115K *
Unlock your potential as a Data Engineer, driving innovative data solutions and optimizing data pipelines. Collaborate with cross-functional teams to enhance data quality and support analytics initiat...
Today
Senior Digital Program Manager
$92K - $136K *
Help us drive customer success by owning and optimizing digital engagement programs. You'll lead strategy, build automated journeys, and analyze performance to enhance customer experiences and ensure...
Reposted today
Senior Developer (AI / Agentic Solutions) | Remote | 6+ Months
$120K - $145K *
Empower innovation by designing intelligent AI agents and automation solutions. Collaborate with architects and stakeholders to implement cutting-edge Generative AI technologies for enterprise applica...
Today
$130K - $150K *
Optimize complex Salesforce implementations by leading cross-functional teams, managing project lifecycles, and ensuring successful client outcomes through effective communication and risk management...
Today
$80K - $90K *
Join a team that's dedicated to strategic program execution and risk mitigation. As a key analyst, you'll prepare and evaluate initiatives, collaborate across functions, and drive project success thro...
Today
$101K - $150K *
Analyze complex data sets to drive insights and recommendations, collaborating with technical teams to enhance analytical capabilities and support client objectives through innovative visualizations a...
Today
$69K - $107K *
Champion client success by leveraging technical expertise to enhance platform value, optimize workflows, and drive measurable outcomes. Collaborate with cross-functional teams to deliver innovative so...
Reposted today
Staff Software Engineer, Infrastructure Foundations
$150K - $180K *
Join a team that's transforming multi-cloud infrastructure. As a Staff Software Engineer, you'll design and build a cohesive platform across AWS, GCP, and Azure, leading a multi-component system while...
Today
$223K - $255K *
Shape the future of patient access through science and evidence. In this field-based role, engage with national and regional payers, providing medical leadership and insights to inform access decision...
Today
Senior Engineering Manager, AI Platform
$150K - $180K *
Lead and develop a high-performing Applied AI team, driving the delivery of production AI systems while ensuring security, reliability, and operational excellence in healthcare applications...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.