Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$90K - $189K *

Help us shape the future of IT Service Management by leading the design and implementation of innovative ServiceNow solutions. Leverage your expertise to mentor developers and drive strategic initiati...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $158K *

Transform business objectives into actionable insights by leveraging Agile methodologies. Collaborate with cross-functional teams to refine backlogs, create user stories, and ensure alignment between...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $210K *

Transform procurement operations by managing and enhancing acquisition systems, ensuring compliance and efficiency while collaborating with stakeholders to implement effective business processes and p...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $158K *

Execute and enhance ServiceNow SPM solutions, driving portfolio management excellence while collaborating with teams to implement best practices and optimize workflows across the enterprise...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $158K *

Unlock innovative data solutions as you design and optimize SAP Data Services workflows, enhancing logistics for the Department of Defense. Collaborate with experts to ensure data quality and drive mi...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $189K *

Elevate your career by delivering innovative SAP SD solutions that enhance operational efficiency and drive strategic objectives. Collaborate with stakeholders to optimize processes and ensure seamles...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$61K - $129K *

Join a team that's dedicated to optimizing CMDB health and governance. Leverage your expertise in ServiceNow to implement, maintain, and enhance data quality initiatives while collaborating with cross...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Empower cross-functional teams by analyzing requirements, facilitating Agile processes, and ensuring alignment between business goals and technical execution. Drive effective backlog management and su...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$98K - $206K *

Elevate your career by developing and maintaining cloud infrastructure for a critical Department of the Air Force project. Collaborate with experts to enhance security and efficiency in an Azure envir...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$75K - $158K *

Empower military logistics by leading SAP Transportation Management solutions. Collaborate across teams to optimize processes, ensuring seamless integration with financial systems while driving innova...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $189K *

Empower progress at the forefront of SAP development, enhancing logistics solutions for national defense. Collaborate with experts to innovate and optimize SAP S/4HANA applications, driving efficiency...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$73K - $155K *

Unlock potential by leading change management initiatives in a dynamic Agile environment. Drive strategic improvements, enhance operational efficiency, and ensure system security while collaborating w...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Lead the charge in validating data quality and integrity for a large-scale SAP S/4HANA implementation. Collaborate with cross-functional teams to ensure accurate data migration, testing, and complianc...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $158K *

Join a team that's dedicated to enhancing accessibility in enterprise applications. Lead Section 508 compliance testing for critical systems, ensuring inclusivity and usability for all users while col...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $189K *

Lead the charge in safeguarding SAP environments by designing, implementing, and maintaining security roles and authorizations across various SAP platforms, ensuring compliance and risk mitigation whi...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$82K - $172K *

Join us to provide vital support as an Acquisition Specialist, overseeing multi-million dollar contracts in naval shipbuilding. Ensure compliance, manage contractor performance, and drive strategic al...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$61K - $129K *

Drive change management initiatives within a dynamic Agile environment, enhancing operational efficiency and security. Collaborate with cross-functional teams to implement best practices and ensure co...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Unlock potential by designing and conducting clinical studies that enhance understanding of new therapies, ensuring quality and efficiency in research deliverables while collaborating with cross-funct...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to empowering customers through expert research guidance. You'll lead onboarding, support research initiatives, and enhance decision-making processes, ensuring impactful i...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $170K *

Lead the charge in managing DLA SecureView, providing critical support and administration for cross-domain solutions, ensuring compliance and seamless connectivity for users across classified networks...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$116K - $175K *

Lead strategic deal structuring and operations, mentoring teams while managing complex, high-value contracts. Collaborate cross-functionally to streamline processes and drive deals to closure, ensurin...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Lead our Rehab Team to enhance the lives of older adults by supervising staff, managing therapy activities, and ensuring optimal patient outcomes in a collaborative environment...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$83K - $109K *

Shape the future of employee technology adoption by enhancing training and support programs. Collaborate with cross-functional teams to empower users, improve productivity, and foster a culture of con...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$83K - $109K *

Drive user identity management and access governance, ensuring secure, timely access to technology resources. Collaborate with HR and IT teams to enhance employee experience while maintaining complian...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$82K - $105K *

Transform complex network infrastructures by designing, deploying, and managing solutions for diverse clients. Leverage your expertise to troubleshoot issues, enhance security, and ensure high availab...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.