Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$85K *

Join a dedicated team to provide compassionate care for critically ill patients. Collaborate with healthcare professionals to assess, plan, and implement nursing care, ensuring optimal recovery and su...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Manage strategic sales relationships with national accounts to drive growth in value-based care. Collaborate with leadership teams, execute contract strategies, and support implementations to enhance...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$115K - $180K *

Transform sales strategies and lead a dynamic team to achieve branch goals. Drive customer relationships and operational excellence while leveraging data for decision-making and process improvements i...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$91K - $100K *

Join a team that's dedicated to managing mid and mass market accounts, enhancing customer relationships, and driving revenue growth through proactive solutions selling and collaboration with cross-fun...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$120K - $191K *

Transform the future of file management by leading a critical platform that ensures secure, reliable, and scalable file transfer and integration, while driving customer value and aligning with organiz...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $191K *

Lead the charge in defining and executing the vision for Enterprise File Services, ensuring secure and scalable file management solutions that align with organizational priorities and deliver measurab...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $135K *

Join a team that's transforming data management for supervisory processes. As a Data Management Specialist, you'll ensure data quality and governance, enabling informed decision-making and supporting...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $135K *

Optimize data management processes by serving as a subject matter expert, ensuring supervisory data quality and consistency to enhance business intelligence and support future AI initiatives within a...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $165K *

Unlock your potential as a Senior HR Business Partner, aligning HR strategies with business goals, driving talent initiatives, and fostering a positive workplace culture to enhance organizational effe...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$195K - $265K *

Lead strategic and operational initiatives for clinical study execution, ensuring quality and compliance across the portfolio. Collaborate with cross-functional teams to optimize resources and drive p...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$204K - $276K *

Unlock potential by leading Clinical Risk & Insights, driving systemic investigations and RCA methodologies to enhance clinical execution and decision-making across portfolios, ensuring sustained impr...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$195K - $265K *

Elevate your career by leading innovative clinical site monitoring strategies, ensuring patient safety and data integrity while driving operational excellence across diverse clinical programs in a dyn...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$185K - $251K *

Accelerate progress at the forefront of clinical research by leading the Study Evidence and Readiness function, ensuring inspection-ready evidence and optimal trial conduct across global teams and cli...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Drive new enterprise growth by winning strategic accounts in the alarm monitoring sector. Leverage your expertise to navigate complex sales cycles, build executive relationships, and exceed quotas whi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $135K *

Drive growth by developing relationships and sales opportunities in the pest control and lawn care sectors. Collaborate with a dynamic team to exceed sales quotas and align solutions with customer nee...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$97K - $158K *

Optimize client success by leading Sage Intacct implementations in the construction sector. Manage multiple projects, ensuring timely delivery and high satisfaction while mentoring team members and en...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$219K - $285K *

Lead a regional team of MSLs to drive scientific engagement and strategy execution. Collaborate with stakeholders to enhance field medical excellence and ensure alignment with corporate objectives whi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$173K - $225K *

Drive strategic partnerships with healthcare organizations to enhance care for rare kidney diseases. Collaborate with cross-functional teams to align clinical and operational goals, ensuring impactful...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K - $205K *

Join a team that's dedicated to enhancing crisis response capabilities across the enterprise. Lead the development of crisis management frameworks, ensuring readiness and effective communication durin...

RemoteRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$85K - $120K *

Drive customer success as a technical advisor, optimizing CrowdStrike Falcon adoption and operational excellence. Collaborate with security teams to implement solutions, troubleshoot issues, and enhan...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $120K *

Unlock potential in cybersecurity by engaging in real-time incident response and threat detection for government organizations. Develop your skills in a compliance-driven environment while protecting...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $120K *

Join a dynamic team of technical analysts dedicated to enhancing global security. Engage in real-time incident detection and response, leveraging your IT and cybersecurity expertise to protect organiz...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $185K *

Shape innovative solutions to enhance cybersecurity systems, collaborating with global analysts to protect customers from malicious attacks. Drive product enhancements and ensure operational excellenc...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $165K *

Tackle complex security challenges as a Senior Consultant, focusing on risk exposure, vulnerability management, and red teaming. Mentor junior team members while delivering cutting-edge solutions usin...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $200K *

Champion proactive risk mitigation by leading exposure management and penetration testing initiatives. Collaborate with clients to enhance security strategies while mentoring junior team members in a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.