Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $130K *

Elevate your career by leading structural and finite element analyses of turbomachinery components. Collaborate with engineers to develop methodologies, support design evaluations, and enhance analyti...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Grow your expertise in workforce management by building and optimizing systems that enhance operational efficiency and member experience. Lead cross-functional initiatives to ensure staffing aligns wi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $97K *

Champion workforce optimization by overseeing staffing and operations, ensuring teams are equipped to deliver exceptional member experiences while fostering a supportive work environment...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's redefining the U.S. Hospitality market by developing strategic partnerships and innovative solutions to drive growth and establish a strong presence in luxury and upscale segments...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$140K - $170K *

Lead the charge in transforming Cloud operations to an AI-first model, guiding a team of engineers to design and deploy AI agents that optimize infrastructure in Azure, while collaborating with client...

RemoteRemote

5 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$110K - $132K *

Innovate IT solutions by evaluating project requirements, providing technical support, and maintaining network infrastructure. Collaborate with teams globally to ensure seamless operations and enhance...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $115K *

Unlock your potential by leading strategic enterprise partnerships, driving growth, and fostering executive engagement. Collaborate across teams to enhance multi-layered initiatives and ensure alignme...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Shape the future of EHS&S solutions by architecting scalable digital frameworks, collaborating with stakeholders to define requirements, and guiding technology lifecycles from design to deployment, en...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $189K *

Lead cybersecurity initiatives as an Information System Security Officer, ensuring compliance and robust security controls for critical information systems while collaborating with stakeholders to saf...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $189K *

Join a team that's transforming supply chain operations through Oracle Fusion SCM. Lead the design and configuration of inventory solutions, ensuring real-time visibility and accountability for critic...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$63K - $129K *

Unlock potential by providing advanced support for Momentum Financials, collaborating with stakeholders to resolve issues, and enhancing system functionality in a dynamic environment. Bring your analy...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Innovate solutions by leveraging your expertise in data automation and systems engineering to enhance operational efficiency and support enterprise financial management systems...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $158K *

Champion quality assurance by collaborating in Agile teams to deliver robust software solutions. Leverage your testing expertise to enhance product quality and drive continuous improvement in a dynami...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Elevate your career by leveraging your expertise in business analysis to enhance Momentum Financials and Acquisitions. Collaborate with stakeholders to drive process improvements and ensure effective...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $158K *

Champion the testing of enterprise content management systems, ensuring seamless integration with SAP. Collaborate with cross-functional teams to validate workflows, enhance quality assurance, and dri...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Empower partner marketing initiatives by developing strategies that drive qualified referrals and pipeline growth across diverse partner ecosystems in North America and EMEA. Collaborate with stakehol...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Staffing

$113K - $140K *

Contribute to innovative database solutions by administering and optimizing PostgreSQL systems. Collaborate with developers to enhance performance, security, and reliability while supporting mission-c...

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Execute clinical trial management activities, ensuring quality outcomes and compliance. Collaborate with cross-functional teams, manage timelines and budgets, and build strong relationships with stake...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$111K - $167K *

Optimize the customer journey by leveraging analytics and strategic insights to enhance pipeline generation, forecasting, and sales enablement for a growing Property Care business. Collaborate cross-f...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$133K - $200K *

Transform your career by leading regulatory compliance for Medicaid and Medicare in the U.S. Dental Business Unit. Collaborate with cross-functional teams to enhance compliance controls and drive oper...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Oversee all construction activities from inception to move-in, ensuring quality control, cost management, and adherence to schedules while collaborating with trade partners and internal teams to optim...

5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$69K - $100K *

Inspire excellence in coding operations by leading a dedicated team, ensuring compliance, accuracy, and timely billing. Collaborate with stakeholders to enhance documentation quality and coding integr...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$131K - $237K *

Join our team as a Principal Cloud Systems Engineer, driving modernization initiatives for the DoD. Leverage your expertise in cloud infrastructure and distributed systems to design secure, innovative...

RemoteRemote

5 days ago

  •   11 - 15 years exp.  •   Technical Services

$70K - $91K *

Unlock potential by advocating for patients and coordinating care plans with clinical teams. Collaborate with healthcare professionals to ensure seamless transitions for patients post-ICU, enhancing t...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $105K *

Elevate your career by joining our dynamic team as a Float Therapist, providing essential outpatient care across multiple clinics in the Kansas City area. Enjoy competitive compensation and a supporti...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.