Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$90K - $110K *

Champion data integrity and reporting readiness by managing data ingestion, ensuring quality, and collaborating across teams to support healthcare marketing analytics and decision-making processes...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$102K - $184K *

Unlock potential by leading high-impact engagements in digital assets, guiding clients through evolving risks and regulatory landscapes while enhancing internal controls and operational strategies in...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$170K - $200K *

Lead the charge in shaping our AI strategy and governance, driving innovation across teams. Collaborate with technology and business leaders to embed AI into operations, ensuring responsible use and m...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$132K - $271K *

Join a team that's driving software sales success by originating and advancing opportunities within a defined territory. Collaborate with clients and partners to build a robust pipeline while mentorin...

5 days ago

  •   8 - 10 years exp.  •   Business Services

$122K - $271K *

Transform the pre-sales landscape by delivering impactful software demos, guiding clients through complex sales cycles, and developing reusable assets to enhance engagement and conversion rates across...

5 days ago

  •   8 - 10 years exp.  •   Business Services

$197K - $271K *

Transform analytical discovery in healthcare payment integrity by leveraging advanced analytics, AI, and claims data to uncover savings opportunities and drive innovation across the organization, enha...

5 days ago

  •   11 - 15 years exp.  •   Business Services

$140K - $165K *

Empower your career by proactively identifying and mitigating insider threats. This role involves advanced investigations, threat detection, and collaboration to protect critical data and intellectual...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Staffing

$73K - $110K *

Analyze coding quality data and support compliance initiatives to enhance hospital coding accuracy. Collaborate with teams to develop guidance and conduct audits, ensuring adherence to regulatory stan...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $170K *

Lead strategic contracts management, overseeing development and negotiation of federal contracts. Collaborate cross-functionally to ensure compliance and risk management while driving organizational g...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$170K - $200K *

Lead the charge in expanding assurance services for financial institutions. Drive strategic client relationships, ensure audit quality, and cultivate future leaders while enhancing market presence and...

5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$170K - $316K *

Empower innovation by serving as a key legal advisor on product development, privacy, and emerging technologies. Collaborate with cross-functional teams to navigate complex regulations and ensure comp...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$285K - $500K+*

Transform digital marketing strategies by leading a global team to enhance demand generation and pipeline growth through innovative media tactics and data-driven optimization across diverse channels...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$100K - $120K *

Champion the growth of our AI-driven platform by designing automated workflows, optimizing paid acquisition, and driving organic growth through innovative strategies and creative campaigns across mult...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$221K - $332K *

Lead the charge in transforming service providers through Calix Cloud solutions. Collaborate with teams to design cloud architectures, deliver demos, and guide customers in complex decision-making, dr...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$83K - $117K *

Empower business growth by leading experimentation strategies and analytical initiatives. Utilize advanced statistical techniques to analyze complex datasets, influence decision-making, and drive impa...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $110K *

Join a team that's dedicated to enhancing software quality through innovative testing strategies. Collaborate with cross-functional teams to ensure reliable applications that support clinical research...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead clinical operations and patient care in the Main Operating Room during weekends, ensuring high-quality outcomes and efficient workflows while mentoring staff and collaborating with surgical teams...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Join a team that's dedicated to sourcing top technical talent for innovative automation solutions. Leverage your recruiting expertise to engage candidates and support our mission of enhancing efficien...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Accelerate progress at enterprise-level accounts by driving new-logo acquisition and managing a strategic territory plan. Engage C-suite stakeholders and lead complex sales cycles to achieve significa...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$211K - $264K *

Transform learning experiences by leading the strategy and operations of our enterprise learning technology ecosystem, ensuring effective governance and seamless integration across platforms to enhanc...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$145K - $220K *

Drive the marketing strategy and pipeline generation for a high-growth B2B company. Lead a dynamic team to create demand, optimize engagement, and deliver measurable results while fostering a culture...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$179K - $293K *

Drive regulatory strategies for In Vitro Diagnostics and Digital Health, overseeing development, submissions, and commercialization. Collaborate with stakeholders and lead health authority meetings to...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$190K - $210K *

Drive success by leading a high-impact Cyber Security Sales team, achieving sales targets, and fostering strategic partnerships. Collaborate across functions to align technical and business strategies...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Transform the future of intelligent compiler technologies by designing and optimizing advanced systems that enhance developer productivity and system performance across software and hardware boundarie...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Lead the charge in R&D lifecycle management, overseeing complex formulation projects from concept to commercialization. Collaborate cross-functionally to enhance product development, streamline proces...

5 days ago

  •   5 - 7 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.