Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $150K *

Inspire a culture of payment integrity by leading strategic development and team performance. Drive continuous improvement initiatives while optimizing operational objectives to enhance healthcare com...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Explore innovative solutions as you lead fit-gap discovery engagements, guiding clients through their transition to Oracle E-Business Suite while collaborating with cross-functional teams to ensure se...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$90K - $300K *

Lead the charge in training and coaching Sales Advisors in the field, enhancing their skills in prospecting, inspections, and closing deals while ensuring a top-notch customer experience and achieving...

5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Accelerate your career as a Sr. FP&A Manager, driving financial insights and strategic decision-making across SaaS and payments sectors. Collaborate with leadership and leverage AI tools to enhance op...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$160K - $230K *

Deliver advanced electrical engineering solutions for hyperscale data centers. Lead design teams, oversee project execution, and ensure compliance with industry standards while fostering client relati...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Technical Services

$128K - $192K *

The Workday Financials Senior Principal Consultant, Record to Report is a dynamic professional responsible for leading the Financials workstream and ensuring operational efficiency in Workday engageme...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$97K - $174K *

Unlock potential by joining a dedicated Pediatric ENT team, providing specialized care to children in an outpatient setting. Collaborate with top specialists while enjoying professional growth opportu...

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$159K - $254K *

Engineer a transformative AI-powered Customer Success platform, driving proactive support and growth for restaurants. This high-impact role blends product strategy with AI innovation, ensuring lasting...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $131K *

Lead the charge in engineering excellence for a Salesforce CRM platform. Oversee a team of engineers, ensuring high-quality technical execution, platform reliability, and effective collaboration acros...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$139K - $235K *

Drive regional marketing initiatives that accelerate pipeline growth. Own strategy and execution for campaigns and events, collaborating with sales teams and partners to achieve measurable results whi...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$113K - $164K *

Lead the charge in enhancing client success by strategically advising high-impact clients, fostering executive relationships, and driving solution adoption while mitigating risks and ensuring measurab...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $130K *

Take ownership of large-scale construction projects, managing stakeholders and ensuring compliance. Oversee project governance, track milestones, and enhance processes while fostering client relations...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Transform customer support by leading a high-impact team focused on quality, efficiency, and satisfaction across all channels. Drive strategic initiatives, develop talent, and enhance processes to ens...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Accelerate progress at the intersection of engineering and Oracle systems, providing immediate solutions for production challenges. Own functional support for Oracle WIP, troubleshoot quality plans, a...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Staffing

$170K - $220K *

Oversee and enhance security strategies across applications, cloud, and AI systems. Lead initiatives to mitigate risks, improve security architecture, and foster a culture of security within engineeri...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $120K *

Optimize talent acquisition by sourcing top candidates for technical roles. Collaborate closely with clients to understand their culture and needs, ensuring a seamless recruitment process that enhance...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Staffing

$120K - $145K *

Join a team that's dedicated to enhancing developer experience by building reliable APIs and tools. Collaborate with cross-functional teams to deliver high-quality software solutions that empower cust...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$108K - $130K *

Elevate manufacturing excellence by providing technical leadership in complex processes, enhancing production efficiency, and implementing advanced technologies while collaborating across functions to...

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $119K *

Optimize compliance and risk management by conducting thorough audits, collaborating cross-functionally, and driving continuous improvement in adherence to regulatory standards and operational practic...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $150K *

Lead the charge in driving revenue growth by developing new business opportunities and managing client relationships in the robotics and automation sectors, while collaborating with technical teams to...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Join a team that's redefining mental health technology by developing a cutting-edge brain stimulator platform. Lead fullstack development, enhance user experience, and mentor a talented engineering te...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$121K - $152K *

Shape the future of employee benefits by delivering strategic account management and innovative solutions that drive client growth and retention while fostering impactful partnerships with national ac...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$143K - $169K *

Drive strategic revenue forecasting and reporting for hardware, collaborating with cross-functional teams to enhance decision-making and insights. Engage with executive leadership to shape narratives...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$184K - $287K *

Innovate scalable factory infrastructure for AI model deployment, enhancing performance and reliability across diverse environments. Collaborate with teams to drive technical advancements and streamli...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Accelerate progress at a dynamic organization by leading a talented engineering team. Drive innovation in AI-assisted software development for healthcare solutions, ensuring quality, security, and ope...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.