Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $121K *

Lead impactful training initiatives designed to empower customers globally. Utilize innovative methods and foster strong relationships to enhance learning experiences and drive success across diverse...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Contribute to innovative digital solutions as a Staff Engineer, collaborating with a cross-functional team to enhance custom applications that serve hundreds of thousands. Your technical expertise wil...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $195K *

Take ownership of sales strategy execution in the Retail and Manufacturing sectors, driving complex solution sales and fostering client relationships to achieve revenue goals and enhance service deliv...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $210K *

Lead the charge in overseeing M&A tax strategies, providing expert guidance on domestic and international deals while mentoring a dynamic team to exceed client expectations and drive practice growth...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$85K - $102K *

Engineer robust network solutions while leading complex troubleshooting efforts. Collaborate on system transitions, maintain documentation, and mentor junior staff. Drive process improvements and ensu...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$139K - $209K *

Join a team that's shaping strategic direction and driving execution across markets. This hands-on role requires analytical credibility and strong relationships to influence decisions and achieve meas...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$127K - $190K *

Drive innovative optical solutions in semiconductor metrology. Collaborate with cross-functional teams to design, prototype, and optimize optical systems, ensuring customer satisfaction and alignment...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$112K - $169K *

Elevate product strategy and commercialization for optical solutions, aligning customer needs with market trends. Collaborate across teams to drive growth and ensure product success in the semiconduct...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$100K - $162K *

Unlock potential by delivering compelling sales strategies and presentations, building customer relationships, and achieving sales goals within your territory while upholding ethical practices and com...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Unlock potential by overseeing cybersecurity integration throughout the IT solution development lifecycle. Lead vulnerability assessments and enhance defensive capabilities while collaborating with IT...

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$70K - $91K *

Engage with healthcare professionals to advocate for patients during pre-admission. Utilize clinical expertise to assess needs, coordinate care plans, and facilitate smooth transitions to specialized...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$156K - $250K *

Transform healthcare by providing scientific expertise and insights to healthcare professionals. Engage in strategic partnerships, facilitate research opportunities, and enhance patient outcomes throu...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Analyze market trends and build strong client relationships to drive sales in a dynamic environment. Collaborate cross-functionally to deliver tailored solutions while achieving ambitious revenue targ...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $230K *

Join a team that's dedicated to advancing oncology care by promoting innovative products and building strong relationships with healthcare professionals. Leverage your expertise to drive brand value a...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $125K *

Engage with strategic Oracle customers to drive success through relationship management, implementation guidance, and value realization. Champion customer outcomes and optimize their journey with Redw...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Transportation

$101K - $125K *

Unlock your potential by driving growth as a key player in a dynamic sales team. Collaborate with talented professionals to deliver tailored solutions and foster long-term client relationships, ultima...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $143K *

Lead the charge in enhancing the Oracle EBS Financial Close processes, ensuring accuracy and sustainability. Collaborate with cross-functional teams to document, standardize, and improve financial ope...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$350K - $389K *

Engage your passion for patient care as a Psychiatrist, providing essential mental health services in a supportive outpatient setting. Enjoy a flexible schedule, competitive compensation, and a collab...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$107K - $195K *

Lead the charge in cyber integration for advanced weapon systems, ensuring secure, scalable solutions that enhance operational capabilities. Collaborate with cross-functional teams to implement best p...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Technical Services

$120K - $145K *

Lead the charge in providing strategic legal counsel and transactional support across teams, ensuring compliance and risk management while negotiating diverse contracts to drive business growth and pr...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $130K *

Oversee the entire contract lifecycle, ensuring swift execution while managing risk. Collaborate cross-functionally to negotiate terms and enhance processes, directly impacting revenue and vendor perf...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Lead the charge in programmatic media campaigns, driving strategy and execution for clients. Utilize your expertise to optimize performance, analyze data, and deliver exceptional communication and res...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Media

$67K - $111K *

Transform coding quality through comprehensive audits and targeted education, ensuring compliance with regulations and optimal revenue integrity. Leverage expert knowledge to identify trends and enhan...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$140K - $200K *

Transform our Android experience by owning major features, driving UI/UX innovation, and collaborating across teams to build impactful product solutions. Ideal for strategic thinkers who thrive in fas...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$102K - $122K *

Champion client partnerships by driving strategic media campaigns and fostering relationships. Leverage your expertise in DTC paid media to enhance client success and team collaboration, ensuring impa...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.