Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$134K - $201K *

Lead strategic initiatives in revenue cycle operations, focusing on self-pay and patient financial services. Drive performance, enhance patient experience, and implement continuous improvements across...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead the charge in driving client success by managing relationships, strategizing growth, and leveraging marketing technology. Own a Book of Business, ensuring measurable value and innovative solution...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$145K - $155K *

Transform customer engagements by leading a dynamic team, ensuring project success through effective management and operational oversight. Drive continuous improvement and enhance client satisfaction...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $100K *

Unlock insights as you lead analytics for multi-channel marketing initiatives. Collaborate with cross-functional teams to ensure accurate data tracking and reporting, driving performance through actio...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Media

$110K - $180K *

Accelerate growth by leading a comprehensive marketing strategy that drives awareness and engagement for investment products among retail investors, while collaborating across teams to ensure cohesive...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Shape innovative consumer experiences as a Product Manager, driving strategy, roadmap, and customer insights. Collaborate with marketing and engineering to expand distribution and elevate web and mobi...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$145K - $175K *

Elevate enterprise application strategy by leading a dynamic team to align technology with business goals, ensuring optimal portfolio management, user experience, and measurable outcomes for sustained...

5 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$165K - $182K *

Elevate your impact as a product marketer, driving launch strategies and messaging. Collaborate across teams to shape customer narratives and improve market understanding, ensuring alignment with busi...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$180K - $220K *

Transform mental health care by providing expert psychiatric assessments, diagnoses, and treatments. Lead interdisciplinary teams, prescribe medications, and serve as a consultant, ensuring comprehens...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$123K - $142K *

Support the execution of Enterprise Risk Management programs, collaborating across teams to enhance risk governance and training initiatives. Drive project management efforts, ensuring timely identifi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$132K - $156K *

Lead the charge in governance, risk, and compliance initiatives, driving process optimization and collaboration across teams. Utilize strategic thinking to manage projects, enhance training programs...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $130K *

Drive revenue growth and cultivate strategic partnerships by leveraging your sales expertise. Collaborate across teams to deliver innovative solutions, effective proposals, and maintain relationships...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$160K - $192K *

Join a team that's driving commercial performance by engaging healthcare providers, building relationships, and supporting innovative therapies to enhance patient access and outcomes across your terri...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Accelerate progress at driving new client partnerships and revenue growth within a high-autonomy, results-driven sales environment. Own the complete sales cycle, leveraging networks to create strategi...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Business Services

$90K - $110K *

Transform patient care by conducting evaluations, managing medication plans, and ensuring compliance with healthcare standards. Collaborate with medical teams to enhance treatment quality and maintain...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$160K - $200K *

Lead the charge in driving growth and innovation for life sciences learning solutions. You'll develop and execute business strategies, enhance client engagement, and modernize product offerings within...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Deliver exceptional customer value by driving onboarding, adoption, and long-term success for a portfolio of clients. Leverage commercial insight and strong relationships to maximize platform utilizat...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$122K - $338K *

Shape the future of learning managed services by driving strategic engagements, enhancing operational models, and fostering high-performing teams to deliver impactful outcomes for clients across diver...

5 days ago

  •   8 - 10 years exp.  •   Business Services

$95K - $115K *

Analyze and optimize the clinical data lifecycle, ensuring data completeness and integrity. Collaborate cross-functionally to enhance clinical data flows and vendor strategies, driving quality improve...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$223K - $290K *

Lead the technical strategy for data products, driving clinical data capabilities and insights. Collaborate with teams to optimize data ingestion processes and implement AI-assisted development workfl...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$129K - $168K *

Optimize internal monitoring processes by leading clinical evaluations and audits across operational functions. Drive compliance, enhance decision-making, and foster team development to ensure alignme...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$188K - $245K *

Drive innovative UX design strategies in clinical settings, leading a talented team to enhance decision support and care coordination. Collaborate across functions to integrate AI and elevate user exp...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$317K - $375K *

Take ownership of the pharmacy business, driving strategy, growth, and performance. Lead a skilled team, manage P&L, and ensure compliance while enhancing member experiences in a regulated environment...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a dynamic team as a technical liaison, developing innovative solutions for customer needs in material handling and automation. Collaborate with sales and engineering to drive project success and...

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$134K - $241K *

Deliver transformative transportation solutions by leading project teams, enhancing community infrastructure, and ensuring excellence in project execution through strategic planning and collaboration...

RemoteRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.