Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$200K - $400K *

Launch your legal career by advocating for injured clients in a collaborative team environment. Utilize your expertise in personal injury or insurance defense to maximize client recovery and make a me...

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$180K - $210K *

Lead the charge in advancing strategic partnerships with health plans. Shape and optimize BetterHelp’s payer strategy, enhance agreements, and identify growth opportunities while collaborating across...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$107K - $150K *

Transform the security landscape by implementing and supporting cutting-edge physical security systems, ensuring client satisfaction and seamless integration for improved safety and network efficiency...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Champion the future of HR service delivery by leading a dynamic team focused on benefits and compensation. Drive operational excellence, enhance associate experiences, and ensure compliance while coll...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$140K - $160K *

Join a dynamic team to execute complex physical electrical designs for medium- and high-voltage substations and utility-scale projects, ensuring quality and compliance from concept through constructio...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Technical Services

$95K - $115K *

Empower your career by driving top-of-funnel growth and cultivating key end user relationships in vertical markets, influencing specifications early in design processes while collaborating with intern...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Optimize business development efforts by driving early-stage opportunity creation in key verticals, engaging decision-makers, and fostering long-term relationships to support growth strategies and rev...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$107K - $182K *

Lead the charge in driving revenue and market presence for IBM i & AIX services. Collaborate across teams to optimize offerings, establish partnerships, and enhance engagement with clients, ensuring t...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$108K - $130K *

Join a team that's dedicated to advancing aviation safety by overseeing flight test operations, managing personnel, and ensuring compliance with FAA standards while fostering a culture of innovation a...

5 days ago

  •   Less than 5 years exp.  •   Transportation

$115K - $135K *

Grow your career with leadership in business development, targeting the Behavioral Health sector. Leverage your expertise to drive sales, establish client relationships, and exceed financial goals whi...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$180K - $220K *

Transform community health by joining a collaborative pediatric team, overseeing patient care and mentorship while gradually building your practice with established patients and support from experienc...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$135K - $160K *

Lead the development and operation of a cutting-edge Security Observability & Data Platform, enhancing endpoint security, threat detection, and incident response while driving innovation in security s...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $200K *

Oversee the management and development of a large contract surety book, identifying opportunities, building agency relationships, and ensuring effective underwriting practices in a remote role coverin...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$65K - $100K *

Lead and develop high-performing teams while driving financial performance and enhancing customer service. Collaborate with stakeholders to implement business solutions and foster a culture of belongi...

5 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$129K - $168K *

Support the strategic development and execution of Medicare growth initiatives, guiding teams in product strategy, competitive analysis, and bid management to drive profitable growth and successful ma...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $250K *

Drive critical initiatives by navigating ambiguity, building effective operating models, and ensuring measurable outcomes in a dynamic environment. Engage with leadership to implement AI solutions and...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$128K - $160K *

Manage the integration and presentation of financial data within a leading market intelligence platform. Collaborate with cross-functional teams to enhance search and agentic capabilities, ensuring da...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$200K - $250K *

Transform your career by leading cross-functional R&D initiatives that enhance platform security and modernization. Drive impactful engineering decisions while mentoring a team of Staff Engineers to a...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$122K - $338K *

Lead transformative Oracle solutions that enhance supply chain and business operations. Collaborate with clients to design scalable architectures, ensuring seamless integration across various Oracle a...

5 days ago

  •   8 - 10 years exp.  •   Business Services

$122K - $187K *

Unlock potential by driving sales growth in the Mid-Market Direct segment, engaging with leading AWS clients and leveraging cloud technology solutions to meet industry needs and achieve sales targets...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Business Services

$141K - $278K *

Pioneer advanced Manufacturing Execution Systems solutions. Lead design, implementation, and continuous improvement initiatives across diverse client environments. Collaborate to drive operational exc...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$87K - $253K *

Champion integrated, multi-function operating models for Global Capability Centers. Drive operational excellence and scalable solutions by leveraging cross-functional expertise and innovation to align...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$135K - $160K *

Lead the charge in driving operational excellence and market growth. As a senior leader, you'll oversee performance, customer relationships, and team development, ensuring alignment with strategic goa...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$141K - $278K *

Advance MES solutions by leading discussions, gathering requirements, and delivering scalable implementations in a dynamic environment. Collaborate with technical architects to drive innovation and ef...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Unlock potential by joining our dynamic team to build robust back-end systems that power AI-driven workflows and enhance user experiences across platforms. Collaborate with engineers to innovate and s...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.