Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$100K - $120K *

Drive production support excellence by troubleshooting integration failures and ensuring data quality across Claims Management applications, collaborating with cross-functional teams to maintain opera...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Unlock potential by leading workforce development initiatives that align education with labor market needs. Drive partnerships, secure funding, and advocate for students while ensuring compliance and...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$68K - $113K *

Champion the enhancement of data security services by managing complex projects and day-to-day operations. Utilize technical expertise to safeguard sensitive information and ensure compliance with ind...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Business Services

$130K - $160K *

Unlock new business opportunities as you drive sales strategies, engage clients, and close deals. This role empowers you to act autonomously while collaborating with cross-functional teams to exceed c...

Missouri, USRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$111K - $130K *

Empower investor relationships by delivering precise financial reporting and enhancing investor experiences through continuous improvements. Collaborate with cross-functional teams to support a divers...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $150K *

Accelerate your sales career by owning a territory, building relationships, and driving revenue through premium F&I products. This role offers autonomy and support as you engage with dealerships and c...

5 days ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Transform your career by leading onsite commissioning activities for advanced data center projects. Drive coordination across teams, ensuring quality and timely deployment of BMS/EPMS systems in a fas...

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$175K *

Optimize revenue cycle management by leading a dynamic team to enhance processes, drive automation, and ensure compliance in a fast-paced telehealth environment. Collaborate with cross-functional team...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$64K - $102K *

Join a dedicated team as you perform ultrasound imaging studies, ensuring high-quality patient care across all age groups. Collaborate with physicians and maintain equipment while contributing to a sa...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$140K - $175K *

Develop innovative software solutions that enhance access to mental and physical health services. Collaborate with cross-functional teams to deliver reliable applications, ensuring quality and perform...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Analyze data trends and drive strategic initiatives to enhance operational efficiency. Collaborate with cross-functional teams to implement innovative solutions and optimize processes, ensuring alignm...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$78K - $126K *

Play a key role in enhancing IT risk management for diverse clients. Leverage your expertise in cybersecurity and compliance to optimize systems and processes while working collaboratively with teams...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$178K - $338K *

Inspire innovation in healthcare by architecting RPA solutions that streamline revenue cycle processes while providing project management and technical expertise to drive client success and team colla...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$138K - $165K *

Empower a high-performing engineering team to enhance POS payments, driving collaboration across departments and ensuring top-notch software delivery while fostering innovation and professional growth...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$230K - $270K *

Advance the technical direction of backend systems, designing scalable services and APIs. Collaborate with cross-functional teams to enhance customer experience and drive impactful solutions while men...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Lead a dynamic customer support team, enhancing operations and quality while managing 24/7 global service. Collaborate cross-functionally to optimize performance and drive customer satisfaction throug...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$199K - $235K *

Champion the development of secure backend services and APIs, enhancing user administration capabilities. Collaborate across teams to ensure reliable, high-quality software while mentoring peers and d...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Empower your career by leading security engineering initiatives across product, cloud, and AI domains. Drive security architecture, vulnerability management, and team growth while ensuring robust secu...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$105K - $148K *

Lead assessments and develop strategies for cybersecurity, privacy, and AI risk. Collaborate with clients to enhance their security programs, ensuring compliance with regulations and frameworks while...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $145K *

Grow your career with a dynamic role managing trust accounts, ensuring compliance, and delivering exceptional client service while collaborating with financial professionals to enhance trust relations...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Champion the future of hypersonic testing by leading test planning, execution, and data analysis. Collaborate with experts to enhance national defense capabilities while ensuring safety and performanc...

5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$100K - $120K *

Drive product strategy by leveraging CMC expertise to translate customer needs into actionable requirements, collaborating with cross-functional teams to deliver user-focused solutions in an agile env...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the execution of complex material-handling installations, ensuring safety, quality, and financial discipline. Oversee site operations, manage teams, and maintain customer relationships while driv...

RemoteRemote

5 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$160K - $200K *

Drive growth and innovation by leading commercial strategies in the Media, Entertainment, and Gaming sectors. Collaborate with teams to enhance client relationships, identify new opportunities, and en...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Media

$135K - $155K *

Lead and mentor a team of data engineers to design, develop, and maintain scalable data pipelines and warehouses, collaborating with stakeholders to deliver key metrics and establish data strategy acr...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.