Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$100K - $120K *
Champion a dynamic sales team while building lasting client relationships. Leverage your extensive sales experience to implement strategies, mentor new members, and drive growth in a flexible, client...
5 days ago
$95K - $115K *
Unlock potential by leading the accounting function, ensuring accurate financial reporting, managing audits, and developing a high-performing team. Collaborate across departments to drive process impr...
5 days ago
$150K - $180K *
Pioneer the development of innovative technology solutions, driving product strategy and AI integration to enhance operational efficiency and customer experience across the insurance lifecycle. Lead a...
5 days ago
Enterprise Customer Success Manager
$130K - $150K *
Drive strategic account management for top-tier restaurant brands, fostering relationships with senior leadership and ensuring their success through innovative solutions and AI integration, while lead...
Reposted 5 days ago
$120K - $145K *
Lead the charge in advancing AI applications in healthcare by developing intelligent agents that uncover financial opportunities within complex datasets, transforming manual analyses into scalable wor...
5 days ago
Strategic Business Development Director
$150K - $180K *
Unlock new business opportunities by leading strategic development initiatives across key markets. Drive enterprise partnerships through consultative selling, executive networking, and rigorous opport...
5 days ago
Psychiatric Nurse Practitioner - Inpatient
$100K - $120K *
Collaborate with healthcare teams to provide psychiatric evaluations and treatment, ensuring quality care and compliance with state guidelines for Nurse Practitioners while fostering patient and famil...
5 days ago
$110K - $130K *
Accelerate progress at the forefront of enterprise sales, driving growth through strategic relationship building and complex deal management. Own the sales lifecycle while collaborating with teams to...
5 days ago
Senior CPX Operations Manager, Customer Success
$74K - $125K *
Drive operational efficiency and optimize workflows within the Customer Success organization, managing projects and enhancing systems to support continuous improvement and data integrity across teams...
5 days ago
$80K - $95K *
Champion a dynamic team environment by managing logistics, mentoring staff, and enhancing customer experiences. Embrace challenges and drive growth in a fast-paced setting while collaborating closely...
5 days ago
Special Needs Plans (SNP) Operations Manager
$73K - $130K *
Join a team that champions regulatory compliance and operational excellence in SNP programs. You’ll lead the oversight of CMS standards, driving process improvements and ensuring high-quality care del...
Reposted 5 days ago
Licensed Clinical Social Worker (Remote)
$78K - $92K *
Champion virtual behavioral health services by providing evidence-based counseling and developing treatment plans for military personnel, ensuring compliance with clinical standards and enhancing pati...
5 days ago
$100K - $125K *
Empower project success by coordinating resources and stakeholders to deliver on time and within scope. Drive effective communication and risk management while ensuring alignment and achieving project...
Reposted 5 days ago
$160K - $200K *
Shape and drive commercial strategies to enhance revenue growth and client relationships across diverse consumer brand sectors. Collaborate with teams to ensure client satisfaction while identifying n...
Reposted 5 days ago
Associate Director - Medical Science Liaison, Oncology (GI/Thoracic Focus) - Upper Midwest
$156K - $250K *
Lead the charge in scientific dialogue with key healthcare professionals, providing critical insights and support within your therapeutic area. Utilize your expertise to enhance patient outcomes and f...
Reposted 5 days ago
$100K - $120K *
Join a dynamic team as a Sr. Support Engineer, providing expert pre- and post-sales technical support for 5G solutions. Collaborate with customers and partners to resolve complex issues, enhance team...
5 days ago
$59K - $110K *
Contribute to patient care by providing virtual education and support, enhancing engagement throughout the treatment journey. Collaborate with management to improve processes and ensure compliance whi...
5 days ago
Business Development Lead (South Central Region)
$115K - $140K *
Unlock potential by driving foodservice sales growth across the South Central Region. Build strategic customer relationships, develop new business opportunities, and collaborate with cross-functional...
5 days ago
Sr Backend Software Engineer I
$140K - $160K *
Lead the development of a robust web application by designing, coding, and testing software while mentoring junior engineers. Collaborate on process improvements and ensure compliance with industry re...
Reposted 5 days ago
$108K - $130K *
Lead the charge in engineering excellence, overseeing project management and technical solutions for gas utility infrastructure. Drive compliance, staff development, and innovative practices to ensure...
5 days ago
$98K - $183K *
Engage senior-level stakeholders and drive complex sales growth by developing data-driven solutions and strategic account plans, ensuring customer objectives are met and revenue is increased across Co...
Reposted 5 days ago
$160K - $175K *
Unlock potential by leading the design and implementation of scalable analytics solutions. Collaborate with stakeholders to enhance data-driven decision-making and mentor teams in analytics engineerin...
5 days ago
Senior Medicaid Technical Business Analysis Engineer
$81K - $105K *
Analyze Medicaid operations and claims processing to drive system solutions. Collaborate with stakeholders to enhance efficiency and compliance while addressing complex business challenges in a fast-p...
5 days ago
Staff Software Engineer - Cloud Services
$145K - $175K *
Pioneer innovative cloud architectures and drive scalable solutions for a cloud-native platform. Collaborate with engineering leaders to enhance reliability, security, and performance while mentoring...
5 days ago
Revenue Accounting Manager | United States | Remote
$120K - $145K *
Empower your career as a Revenue Accounting Manager, ensuring compliance and accuracy in revenue recognition. Collaborate cross-functionally to enhance processes and drive month-end close excellence i...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.