Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$100K - $120K *

Champion a dynamic sales team while building lasting client relationships. Leverage your extensive sales experience to implement strategies, mentor new members, and drive growth in a flexible, client...

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Unlock potential by leading the accounting function, ensuring accurate financial reporting, managing audits, and developing a high-performing team. Collaborate across departments to drive process impr...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Pioneer the development of innovative technology solutions, driving product strategy and AI integration to enhance operational efficiency and customer experience across the insurance lifecycle. Lead a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $150K *

Drive strategic account management for top-tier restaurant brands, fostering relationships with senior leadership and ensuring their success through innovative solutions and AI integration, while lead...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$120K - $145K *

Lead the charge in advancing AI applications in healthcare by developing intelligent agents that uncover financial opportunities within complex datasets, transforming manual analyses into scalable wor...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Unlock new business opportunities by leading strategic development initiatives across key markets. Drive enterprise partnerships through consultative selling, executive networking, and rigorous opport...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Collaborate with healthcare teams to provide psychiatric evaluations and treatment, ensuring quality care and compliance with state guidelines for Nurse Practitioners while fostering patient and famil...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Accelerate progress at the forefront of enterprise sales, driving growth through strategic relationship building and complex deal management. Own the sales lifecycle while collaborating with teams to...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$74K - $125K *

Drive operational efficiency and optimize workflows within the Customer Success organization, managing projects and enhancing systems to support continuous improvement and data integrity across teams...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$80K - $95K *

Champion a dynamic team environment by managing logistics, mentoring staff, and enhancing customer experiences. Embrace challenges and drive growth in a fast-paced setting while collaborating closely...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$73K - $130K *

Join a team that champions regulatory compliance and operational excellence in SNP programs. You’ll lead the oversight of CMS standards, driving process improvements and ensuring high-quality care del...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $92K *

Champion virtual behavioral health services by providing evidence-based counseling and developing treatment plans for military personnel, ensuring compliance with clinical standards and enhancing pati...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Technical Services

$100K - $125K *

Empower project success by coordinating resources and stakeholders to deliver on time and within scope. Drive effective communication and risk management while ensuring alignment and achieving project...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$160K - $200K *

Shape and drive commercial strategies to enhance revenue growth and client relationships across diverse consumer brand sectors. Collaborate with teams to ensure client satisfaction while identifying n...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Media

$156K - $250K *

Lead the charge in scientific dialogue with key healthcare professionals, providing critical insights and support within your therapeutic area. Utilize your expertise to enhance patient outcomes and f...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a dynamic team as a Sr. Support Engineer, providing expert pre- and post-sales technical support for 5G solutions. Collaborate with customers and partners to resolve complex issues, enhance team...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Transportation

$59K - $110K *

Contribute to patient care by providing virtual education and support, enhancing engagement throughout the treatment journey. Collaborate with management to improve processes and ensure compliance whi...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$115K - $140K *

Unlock potential by driving foodservice sales growth across the South Central Region. Build strategic customer relationships, develop new business opportunities, and collaborate with cross-functional...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$140K - $160K *

Lead the development of a robust web application by designing, coding, and testing software while mentoring junior engineers. Collaborate on process improvements and ensure compliance with industry re...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$108K - $130K *

Lead the charge in engineering excellence, overseeing project management and technical solutions for gas utility infrastructure. Drive compliance, staff development, and innovative practices to ensure...

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$98K - $183K *

Engage senior-level stakeholders and drive complex sales growth by developing data-driven solutions and strategic account plans, ensuring customer objectives are met and revenue is increased across Co...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$160K - $175K *

Unlock potential by leading the design and implementation of scalable analytics solutions. Collaborate with stakeholders to enhance data-driven decision-making and mentor teams in analytics engineerin...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$81K - $105K *

Analyze Medicaid operations and claims processing to drive system solutions. Collaborate with stakeholders to enhance efficiency and compliance while addressing complex business challenges in a fast-p...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Business Services

$145K - $175K *

Pioneer innovative cloud architectures and drive scalable solutions for a cloud-native platform. Collaborate with engineering leaders to enhance reliability, security, and performance while mentoring...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Empower your career as a Revenue Accounting Manager, ensuring compliance and accuracy in revenue recognition. Collaborate cross-functionally to enhance processes and drive month-end close excellence i...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.