Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$115K - $140K *

Drive operational excellence by leading a high-performing field service team, ensuring exceptional customer support and strategic growth while managing complex service challenges and performance metri...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$180K - $220K *

Join a dynamic team to provide comprehensive care in a modern urgent care setting. Leverage your expertise to treat diverse patient needs, collaborate with skilled staff, and contribute to quality out...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $220K *

Join a dynamic team to provide comprehensive care in a modern urgent care setting. Lead the charge in delivering quality patient experiences while collaborating with skilled professionals in a support...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$210K - $250K *

Drive exceptional patient care by providing comprehensive clinical services in a modern, collaborative environment. Enjoy flexible scheduling and a competitive compensation package while making a diff...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Lead the charge in delivering complex healthcare construction projects, ensuring safety, budget adherence, and compliance. Collaborate with multidisciplinary teams to enhance patient care while managi...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$80K - $95K *

Join a dynamic team focused on transforming early literacy by building partnerships with school leaders. Leverage your educational experience to drive sales and enhance student learning through innova...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Join a team that's shaping the future of literacy by building strategic partnerships with school districts. As a key driver of growth, you'll leverage your educational leadership experience to enhance...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $160K *

Unlock potential by designing and optimizing enterprise database environments for mission-critical HRIT applications, ensuring security, scalability, and compliance with federal standards while collab...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $200K *

Shape your career by leading the delivery of quality medical services and program development while managing a dedicated team of medical professionals to enhance patient care and treatment outcomes...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Empower healthcare delivery by guiding medical practice, ensuring quality services, and fostering a collaborative environment. Influence new initiatives while providing clinical consultation and leade...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Lead the charge in developing and evaluating a comprehensive medical practice delivery model while ensuring high-quality patient care and collaborating with leadership to innovate service initiatives...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $194K *

Lead a dynamic Support Engineering team, enhancing customer experiences through AI-driven solutions, mentorship, and scalable processes while fostering a culture of growth and accountability...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Join a team that's dedicated to providing comprehensive dental care in an underserved community. Collaborate with healthcare professionals to enhance patient outcomes while making a meaningful impact...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K *

Empower our operations by leading a dynamic team to ensure timely delivery of medical equipment and services, enhancing patient care through collaboration and strategic oversight in a fast-paced envir...

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $248K *

Advance our product strategy by leading the integration of data center operations into Prism, enhancing diagnostics and decision-making for operators and executives alike. Collaborate with cross-funct...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$94K - $169K *

Join a team that's redefining clinical trial monitoring by leading diverse studies, ensuring compliance, and enhancing processes. Collaborate with experts to drive innovation and improve outcomes in a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $184K *

Pioneer the development and operational convergence through automation, designing CI/CD pipelines and driving release process efficiency to enhance software delivery across diverse teams and projects...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Shape the future of patient care by leveraging your nursing expertise and informatics. Optimize clinical information systems while collaborating with interdisciplinary teams to enhance the overall hea...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in managing and selling Table Games and ETGs to casino operators, enhancing customer satisfaction while maintaining strong relationships and achieving sales targets within your territo...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$85K - $115K *

Empower a positive workplace by resolving employment matters, ensuring compliance, and fostering relationships across departments. Collaborate with leaders to uphold ethical standards and promote a cu...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$113K - $181K *

Pioneer a high-performing team in delivering impactful technical assistance programs. Lead program managers and specialists to enhance service delivery, operational excellence, and partner satisfactio...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Champion project success by managing healthcare architecture initiatives from inception to completion. Lead diverse teams, engage clients, and ensure compliance with industry standards while deliverin...

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Elevate your career by leading strategic finance pilots to drive AI model training and evaluation. This hands-on role combines financial expertise and operational leadership to transform emerging proj...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$70K - $126K *

Join a dynamic team to enhance compliance initiatives, manage regulatory reporting, and lead projects. Play a key role in developing policies, conducting audits, and ensuring adherence to state and fe...

Missouri, USRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$103K - $193K *

Drive your career by leading strategic retail media partnerships, leveraging advanced technology to optimize client success and revenue growth. Act as a consultant and SME, guiding brands through the...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.