Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$120K - $150K *

Empower your career by driving engagement initiatives for physicians in training. Collaborate with medical teams to enhance educational programs and support seamless transitions for graduating trainee...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $95K *

Join as a critical team member to manage and enhance productivity platforms, ensuring stability, security, and user satisfaction. Collaborate across teams to drive operational maturity and navigate co...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Business Services

$288K - $400K *

Inspire a high-performing sales team as you drive strategic growth, nurture talent, and foster customer relationships. Shape long-term sales strategies while managing daily operations to maximize reve...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$135K - $165K *

Empower project success by managing cost control and planning for critical infrastructure projects. Utilize expertise to lead negotiations, provide estimates, and enhance value management across large...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $120K *

Transform the client experience by building data platforms, AI apps, and workflows. Collaborate closely on real-world projects, making key decisions and enhancing your engineering skills in a dynamic...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Lead the charge in demand generation and performance marketing, optimizing campaigns and funnel reporting. Collaborate with Sales and Revenue Operations to enhance data infrastructure and drive measur...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$87K - $157K *

Shape the future of healthcare quality reporting by leading complex, cross-functional projects. Drive strategic initiatives, enhance operational processes, and ensure accountability while collaboratin...

Missouri, USRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Partner with us to lead field sales across diverse channels, driving strategy and performance. Collaborate with executives to optimize business outcomes while developing and mentoring high-performing...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$165K - $243K *

Lead the charge in data engineering excellence by mentoring a team, driving pipeline delivery, and translating stakeholder needs into actionable technical plans while ensuring operational accountabili...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$194K - $236K *

Shape the future of data center development across the Americas by leading execution from origination to NTP. Collaborate with cross-functional teams to ensure project success while driving sustainabi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$116K - $146K *

Drive impactful image programs and projects across multiple channels, ensuring compliance, safety, and customer satisfaction. Manage budgets of $25-$45 million while coordinating with stakeholders and...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$80K - $95K *

Empower seamless travel operations by managing critical systems and integrations. Collaborate with cross-functional teams to enhance performance and security of travel platforms, ensuring optimal user...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$71K - $115K *

Elevate customer success by serving as a strategic advisor for 75+ accounts, driving ROI through tailored solutions, proactive engagement, and cross-functional collaboration to ensure exceptional expe...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$145K - $175K *

Shape the future of cloud infrastructure by ensuring the reliability, scalability, and performance of ClickHouse databases while collaborating across teams and implementing robust processes for incide...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Empower users by creating intuitive video editing tools and features. Collaborate on innovative UI designs and enhance existing functionalities, ensuring a seamless experience for editors transitionin...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $105K *

Manage the EFB program for the 509th Bomb Wing, ensuring devices and publications are secure, current, and compliant. Oversee maintenance, upgrades, and inventory while supporting operational readines...

5 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$70K - $90K *

Transform your leadership skills by mentoring a dynamic workforce while managing safety, quality, and productivity. Collaborate with diverse teams to achieve business objectives in a fast-paced enviro...

5 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$146K - $160K *

Unlock potential by driving new business in LATAM markets. Leverage your expertise in MarTech and analytics to build relationships, manage complex sales cycles, and exceed revenue targets while collab...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Lead innovative product development initiatives, guiding a skilled team to transform concepts into high-quality aluminum fishing boats and pontoons while collaborating across departments to ensure suc...

5 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Lead document review projects by optimizing workflows and technology. Collaborate with counsel and internal teams to ensure quality and efficiency in deliverables, driving down costs while enhancing a...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$120K - $160K *

Empower your career by leading strategic capture efforts to secure significant business opportunities. Collaborate with cross-functional teams to develop winning strategies and drive successful bid su...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Drive impactful solutions by maintaining and developing Finance and Procurement systems. Collaborate with teams to analyze requirements, debug SQL queries, and enhance application performance for a se...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$191K - $247K *

Develop and oversee advanced capabilities in Commercial Learning & Development, driving strategy, implementation, and continuous improvement to enhance field performance and support business objective...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$122K - $199K *

Unlock potential by leading IBM Maximo and Cognos solutions, driving digital transformation, enhancing asset management, and improving operational efficiency within a collaborative team focused on ent...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$150K - $180K *

Lead the charge in managing large-scale data center projects, ensuring profitability, client satisfaction, and team performance while overseeing safety, quality, and risk management throughout the pro...

5 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.