Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $225K *

Drive innovation and strategic leadership in wastewater treatment and reuse projects, guiding multidisciplinary teams to deliver sustainable, cutting-edge engineering solutions while fostering client...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$100K - $125K *

Grow key accounts in the Casino Gaming sector by driving business expansion, identifying opportunities, and delivering tailored computing solutions. Engage with C-level executives to enhance partnersh...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$185K - $210K *

Develop and lead a high-performing Revenue Enablement team, driving strategic initiatives to enhance sales effectiveness and align enablement programs with evolving business needs in a fast-paced envi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Engage in designing and implementing SAP Plant Maintenance solutions for complex federal projects. Collaborate with stakeholders to enhance asset management efficiency and ensure seamless integration...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Drive operational excellence by overseeing clinical, financial, and human resource management across procedural services. Collaborate with diverse teams to enhance service delivery and ensure regulato...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$250K - $300K *

Empower women's health by joining a collaborative OB/GYN practice. Enjoy a four-day work week, mentorship, and a supportive environment while delivering care at a leading medical center. Experience a...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$116K - $148K *

Transform enterprise operations by guiding customers in AI adoption and maximizing Asana's capabilities. Own post-sales relationships, ensuring measurable outcomes and strategic success across a portf...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$137K - $171K *

Drive revenue growth by leading a high-performing sales team focused on expanding existing customer accounts. Collaborate cross-functionally to align strategies and enhance net revenue retention while...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Join a dynamic team to drive sales in Vascular Access and Blood Collection. Leverage your clinical knowledge and sales experience to build relationships with key decision-makers, ensuring optimal cust...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Lead the charge in managing complex projects and mentoring teams while ensuring client satisfaction and technical excellence. Drive project success through effective communication and coordination wit...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$185K - $245K *

Optimize model risk management by validating complex finance and analytics models. Collaborate across teams to identify weaknesses, improve governance, and support model framework implementation. Lead...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $100K *

Optimize enterprise secrets management by implementing and maintaining solutions across multi-cloud environments. Collaborate with teams to integrate security processes, enhance governance, and suppor...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$130K - $150K *

Champion financial excellence as a Controller, leading accounting operations and driving compliance. Collaborate with executive teams, managing audits, reporting, and enhancing operational efficiency...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Tackle project management challenges to successfully oversee construction initiatives. Manage planning, scheduling, cost accounting, and quality control while maintaining strong relationships with sta...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$100K - $120K *

Innovate noise control solutions for large-scale AI data centers. Lead acoustic studies, model sound propagation, and recommend effective mitigations while collaborating across engineering teams to en...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$190K - $210K *

Explore innovative solutions as you lead the design and architecture of scalable healthcare applications, mentor engineers, and collaborate with cross-functional teams to enhance patient experiences a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $220K *

Partner with us to tackle complex engineering challenges, leveraging deep expertise in TypeScript, Postgres, and AWS. Collaborate closely with our VP of Engineering to innovate and deliver impactful p...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Transform the future of power delivery by managing complex transmission line projects. Lead teams, ensure quality, and drive project success while collaborating with engineers and stakeholders across...

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$124K - $187K *

Join a dynamic team to define and guide technical direction across platforms, ensuring scalable, secure solutions that align with business outcomes. Collaborate with cross-functional teams to resolve...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$100K - $150K *

Join a team that's shaping the future of heavy civil construction by managing complex projects from estimation to execution. Leverage your expertise to deliver high-quality results while collaborating...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Staffing

$102K - $170K *

Join a team that's transforming Internal Audit through data analytics and technology. Contribute to innovative audit techniques while collaborating with stakeholders to enhance audit effectiveness and...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Lead the charge in driving revenue growth by developing and executing innovative sales strategies, managing a high-performance team, and fostering key relationships in the industrial manufacturing sec...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $90K *

Join us to lead a newly renovated hotel, driving operations, team culture, and guest satisfaction. This role demands a hands-on leader to enhance performance and foster a positive environment while en...

5 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$89K - $148K *

Drive the maintenance and enhancement of Mainframe systems, ensuring optimal performance and seamless migrations. Collaborate with a multi-disciplinary team to solve technical challenges and implement...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$134K - $265K *

Lead the charge in architecting and delivering Adobe Commerce solutions, optimizing cloud environments, and enhancing integration capabilities. Drive innovation through serverless extensions and APIs...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.