Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$130K - $160K *

Transform the user experience and operational workflows in a complex two-sided marketplace. Lead product initiatives that enhance clinician and district interactions, streamline processes, and drive i...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$190K - $240K *

Deliver high-quality fullstack web solutions, owning major product features from design to launch while collaborating with cross-functional teams to enhance platform reliability and performance...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$172K - $205K *

Transform data into actionable insights to optimize the insurance business. Collaborate with cross-functional teams to enhance customer experience and drive revenue growth through advanced analytics a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$215K - $255K *

Shape the future of early-career Solutions Engineers by leading a dynamic training program. Drive continuous improvement, mentor talent, and ensure alignment with business needs to cultivate high-perf...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$70K - $114K *

Optimize operations by leading the Materials Management Department, overseeing purchasing, warehousing, and distribution. Collaborate with teams to enhance performance and customer satisfaction while...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Join a dedicated team providing psychiatric care to adult patients, collaborating closely with psychiatrists to enhance mental health outcomes and support patient well-being in a dynamic behavioral he...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$133K - $230K *

Accelerate your career by driving local market strategies in oncology sales. Collaborate with key stakeholders to enhance referral pathways and community engagement, while implementing initiatives tha...

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $215K *

Join a dynamic team to manage technology partner relationships, ensuring integration health and driving revenue growth. Collaborate with engineering and commercial teams to resolve issues and optimize...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $100K *

Empower your career as a sales leader in the hospitality sector, driving new business development and building strong client relationships in the coffee and beverage industry. Join a dynamic team focu...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $90K *

Empower patient recovery as an Orthopedic Physical Therapist in our dynamic outpatient setting. Utilize your experience to assess, treat, and guide patients through diverse rehabilitation phases while...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in advancing small molecule drug discovery, driving innovative medicinal chemistry strategies from hit identification to IND-enabling studies while collaborating across disciplines and...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$133K - $230K *

Shape the future of oncology sales by implementing local market strategies, enhancing referral pathways, and cultivating key relationships to drive community engagement and elevate brand presence in t...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Grow your career by driving HVAC commercial sales. Manage your pipeline from prospecting to closing, while collaborating with various teams to deliver effective solutions that meet customer needs and...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$121K - $182K *

Lead the charge in designing and optimizing secure Azure Virtual Desktop environments. Collaborate with cross-functional teams to ensure high availability and performance, delivering top-quality solut...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Lead the charge in advancing IoT solutions by providing expert technical support for industrial connectivity. Collaborate with teams and clients to enhance digital initiatives while ensuring complianc...

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$274K - $356K *

Transform the actuarial function by leading AI-enabled workflows and modern analytics, improving decision-making and fostering collaboration across Finance, Clinical, and Growth teams while ensuring c...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive the future of engineering workflows by building and delivering robust AI-driven automation and agent-based capabilities, ensuring products meet real customer needs and are reliable for complex e...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$87K - $253K *

Shape the future of HR by leading transformative process design and AI integration. Collaborate with clients to redefine HR functions, enhance employee experiences, and drive measurable business outco...

5 days ago

  •   5 - 7 years exp.  •   Business Services

$150K - $180K *

Shape impactful customer journeys as a Staff Software Engineer, leading technical initiatives and collaborating across teams to enhance product capabilities and drive growth. Your expertise will influ...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$122K - $292K *

Transform asset management by leading enterprise projects that enhance operational efficiency. Collaborate with stakeholders to implement innovative solutions using AI and digital technologies, drivin...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Business Services

$85K - $120K *

Optimize the software development process by contributing to product-focused projects, addressing coding, debugging, automated testing, and performance enhancement to ensure scalable and efficient sof...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$90K - $115K *

Join a dynamic team where you'll source innovative talent using cutting-edge AI tools, enhance candidate experience, and coordinate recruitment processes. This role offers growth potential across sour...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Develop comprehensive lifecycle acquisition strategies for GEOINT systems, providing technical and program management support from concept to operational use. Collaborate with stakeholders to ensure c...

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

The Channel Partner Sales Manager at HiddenLayer is responsible for driving pipeline and revenue through strategic Value-Added Resellers (VARs) while collaborating closely with the direct sales team...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Drive mechanical design excellence for mission-critical facilities, overseeing project execution and mentoring junior engineers. Collaborate across disciplines to ensure accurate construction document...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.