Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$120K - $140K *

Optimize total rewards and HR operations by partnering with leaders to enhance employee experience, drive strategic initiatives, and ensure compliance while fostering a culture of continuous improveme...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Media

$107K - $213K *

Accelerate progress at clinical research sites by leading activation efforts, ensuring compliance and efficiency. Collaborate cross-functionally to manage risks and drive project milestones, while men...

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $175K *

Lead the charge in driving industry-specific solutions through innovative showcases. Collaborate with cross-functional teams to enhance customer engagement and partner management, ensuring alignment w...

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$73K - $102K *

Collaborate with stakeholders to drive PLM transformation using PTC Windchill. Utilize strong technical skills to configure, customize, and integrate Windchill solutions, ensuring business processes a...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Optimize client strategies and drive business growth by leading integrated media planning across channels. Collaborate with cross-functional teams to translate insights into actionable recommendations...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Media

$115K - $140K *

Champion patient care by providing testing and psychotherapy services. Enjoy flexible schedules, competitive compensation, and a supportive team environment while maintaining a strong work/life balanc...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Lead the charge in developing innovative AI software solutions, enhancing system performance, and collaborating with teams to align with IT roadmaps. Drive improvements through analysis and ensure sea...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Lead the charge in managing appraisal projects, ensuring accuracy and client satisfaction from intake to delivery while coordinating with specialists and maintaining quality standards...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K *

Reimagine the TikTok Shop affiliate landscape by developing and expanding a dynamic creator network. Collaborate with strategists to drive sales through targeted outreach and relationship-building, wh...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$200K - $225K *

Lead the legal strategy for commercial agreements, driving innovative monetization models and partnerships in gaming and entertainment. Collaborate with cross-functional teams to support high-volume d...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Champion operational excellence by leading a DevOps team to enhance service resilience and efficiency in trading infrastructure. Collaborate globally to ensure secure, reliable, and scalable services...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$54K - $116K *

Unlock potential by joining a dedicated team of Behavioral Health professionals. Review authorization requests and ensure timely, evidence-based treatment for members, focusing on inpatient mental hea...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Optimize machine learning solutions by leveraging traditional algorithms and financial data. Collaborate with clients to enhance product delivery and integrate seamlessly into teams, driving impactful...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$221K - $304K *

Join a team that's redefining manufacturing excellence in the Fresh Bakery sector. Lead strategic initiatives across multiple sites, driving safety, quality, and operational performance while fosterin...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Food & Beverages

$110K - $152K *

Drive operational excellence by enhancing performance across safety, quality, and cost metrics. Collaborate with cross-functional teams to implement improvements, standardize practices, and build capa...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$202K - $253K *

Drive the development of AI-driven coaching solutions, overseeing multiple squads from prototype to production. Ensure quality delivery, manage resources effectively, and foster team growth while main...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$71K - $106K *

Join our dedicated team to assess and meet patient needs in a fast-paced environment. Collaborate with multidisciplinary teams to deliver high-quality care and ensure optimal patient outcomes in a pro...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$99K - $164K *

Lead strategic IT planning and delivery oversight, aligning initiatives with business goals. Collaborate with leadership to optimize resources, enhance governance, and drive Agile practices within a d...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$156K - $181K *

Unlock potential by driving enterprise risk management through advanced analytics and reporting solutions. Collaborate with stakeholders to enhance decision-making and operational effectiveness while...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $160K *

Transform the user experience and operational workflows in a complex two-sided marketplace. Lead product initiatives that enhance clinician and district interactions, streamline processes, and drive i...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$190K - $240K *

Deliver high-quality fullstack web solutions, owning major product features from design to launch while collaborating with cross-functional teams to enhance platform reliability and performance...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$172K - $205K *

Transform data into actionable insights to optimize the insurance business. Collaborate with cross-functional teams to enhance customer experience and drive revenue growth through advanced analytics a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$215K - $255K *

Shape the future of early-career Solutions Engineers by leading a dynamic training program. Drive continuous improvement, mentor talent, and ensure alignment with business needs to cultivate high-perf...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$70K - $114K *

Optimize operations by leading the Materials Management Department, overseeing purchasing, warehousing, and distribution. Collaborate with teams to enhance performance and customer satisfaction while...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Join a dedicated team providing psychiatric care to adult patients, collaborating closely with psychiatrists to enhance mental health outcomes and support patient well-being in a dynamic behavioral he...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.