Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $150K *

Lead the charge in driving business development for Technical Flooring, identifying new opportunities, cultivating strategic partnerships, and enhancing client relationships to achieve growth and prof...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Lead the charge in engineering excellence by managing multidisciplinary design efforts, facilitating project success while maintaining utmost quality and compliance. Drive collaboration among teams to...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$90K - $110K *

Champion the recruitment process by sourcing top technical talent, collaborating with leadership, and executing full-cycle hiring strategies to meet business objectives in a fast-paced startup environ...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Empower a dynamic team of Project Managers to drive successful product implementations, enhance operational efficiency, and achieve key performance metrics while fostering cross-functional collaborati...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $182K *

Lead client implementations and provide ongoing support for Sage HCM solutions. Guide customers through the full implementation lifecycle, ensuring successful outcomes and optimizing their HCM environ...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $95K *

Pioneer innovative clinical workflows and enhance service performance in specialty care. Collaborate with stakeholders to implement programs, analyze outcomes, and drive improvements, ensuring excelle...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Join as a strategic leader in Revenue Operations, driving growth initiatives and optimizing performance for a $750M+ Business Unit. Collaborate with executive teams to enhance revenue strategies, fore...

RemoteRemote

5 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$100K - $130K *

Grow your career with an opportunity to drive sales and build client relationships across a diverse territory. Leverage your technical expertise to promote innovative solutions and achieve results, en...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$107K - $167K *

Shape the future of health and safety by leading compliance efforts across diverse projects. Collaborate with teams nationwide to ensure safe execution through planning, audits, and site evaluations...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Technical Services

$80K - $95K *

Unlock potential by leading a dynamic support team, resolving complex digital banking issues, and enhancing service delivery. Drive operational excellence while mentoring junior specialists and collab...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$170K - $200K *

Unlock potential by overseeing large-scale data center construction projects, ensuring timely delivery, budget adherence, and quality standards while collaborating with diverse stakeholders across all...

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $145K *

Lead product development initiatives by driving innovative solutions in power connectors and cable assemblies. Collaborate cross-functionally to ensure high-quality, cost-effective designs that meet c...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Lead global automation initiatives, driving strategy and execution across manufacturing sites. Oversee teams to enhance productivity, quality, and cost efficiency, focusing on cable assembly operation...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$104K - $135K *

Lead the charge in driving strategic growth via innovative Paid Social campaigns across platforms. Own metrics, collaborate cross-functionally, and implement cutting-edge tactics to significantly enha...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$115K - $150K *

Innovate your career with a strategic role focused on omnichannel marketing. Lead data-driven insights and creative recommendations for a top financial services brand, collaborating across teams to en...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$170K - $200K *

Unlock potential by leading strategic finance initiatives, enhancing planning, forecasting, and reporting processes. Collaborate with executives to drive operational excellence and scale the finance f...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $150K *

Transform treasury operations by building infrastructure for international and commercial expansion, managing complex cash flows, overseeing debt compliance, and enhancing banking relationships, while...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$98K - $120K *

Unlock potential by designing and delivering impactful leadership programs that enhance employee capabilities and align with business goals. Collaborate with HR and leaders to create effective learnin...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$80K - $108K *

Drive financial excellence by supporting global markets through modeling, forecasting, and analysis. Collaborate with cross-functional teams to enhance business performance and present insights to sen...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$163K - $287K *

Lead global litigation management and enhance compliance initiatives while driving strategic legal guidance across pre-litigation matters and ensuring operational alignment with business goals in a dy...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$164K - $262K *

Elevate your career by designing and building self-service cloud APIs and services. Collaborate with teams to transform complex cloud operations into reliable, user-friendly products that enhance deve...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $152K *

Engineer innovative solutions in nuclear power plant systems design. Collaborate on modification packages, technical specifications, and vendor evaluations while leading project teams to enhance opera...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Technical Services

$120K - $130K *

Elevate content strategy for Cell & Gene Therapy, translating complex science into clear messaging. Lead global campaigns, engage stakeholders, and ensure compliance while driving business growth and...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Optimize total rewards and HR operations by partnering with leaders to enhance employee experience, drive strategic initiatives, and ensure compliance while fostering a culture of continuous improveme...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Media

$107K - $213K *

Accelerate progress at clinical research sites by leading activation efforts, ensuring compliance and efficiency. Collaborate cross-functionally to manage risks and drive project milestones, while men...

5 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.