Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Associate Director, R&D Strategy & Strategic Initiatives
$155K - $205K *
Join a team that's shaping the future of R&D strategy by analyzing complex challenges, developing actionable insights, and driving innovative initiatives across global research and development efforts...
5 days ago
Senior Director, R&D Strategy Execution & Transformation
$223K - $293K *
Accelerate progress at the forefront of R&D transformation, leading strategic initiatives and cross-functional teams to drive measurable outcomes and enhance organizational effectiveness in a dynamic...
5 days ago
$100K - $120K *
Transform financial planning by developing models, tracking expenses, and conducting analyses. Collaborate with FP&A teams to prepare cash flow projections and monthly reports, driving insights for en...
5 days ago
Lifecycle Acquisition Analyst, Mid
$78K - $90K *
Empower the acquisition lifecycle by developing key documents and coordinating with teams to ensure timely, well-defined procurement actions for NGA programs. Engage in meetings and provide independen...
5 days ago
Financial & Budget Management Analyst, Senior
$128K - $140K *
Lead financial management activities for NGA programs, analyzing budgets, justifying resource allocations, and ensuring program financial health. Serve as a key financial expert, providing insights an...
5 days ago
$75K - $104K *
Join a team that's dedicated to enhancing claims operations and driving efficiency. Lead a dynamic group, resolve customer discrepancies, and implement sustainable solutions to improve financial accur...
5 days ago
Consulting Director, Environmental FERC
$125K - $150K *
Engage as a trusted advisor in environmental consulting, leading major natural gas and LNG projects. Drive permitting strategies, manage interdisciplinary teams, and foster client relationships while...
5 days ago
Managing Consultant, Environmental Regulatory FERC Specialist
$95K - $115K *
Drive strategic permitting initiatives for complex energy projects, ensuring compliance with FERC regulations. Leverage your expertise to influence regulatory outcomes and support sustainable energy s...
5 days ago
Enterprise Sales Director - New England / NY
$150K - $180K *
Lead the charge in driving enterprise healthcare IT sales, fostering strategic relationships, and achieving growth targets across assigned accounts and territories. Collaborate with teams to enhance m...
5 days ago
People Business Partner - West
$92K - $138K *
Transform workforce strategies as a key People Business Partner, advising leaders on staffing, performance, and talent management. Drive engagement and culture initiatives while ensuring compliance an...
5 days ago
SAP Source-to-Pay Application Specialist
$124K - $177K *
Join a team that's dedicated to optimizing procurement processes and elevating user experience through the administration and integration of SAP Ariba within a comprehensive Source-to-Pay framework, d...
Reposted 5 days ago
Associate Director, Clinical Drug Safety
$117K - $189K *
Champion safety excellence by leading pharmacovigilance efforts, analyzing safety data, and ensuring compliance across clinical programs. Collaborate with cross-functional teams to deliver high-qualit...
5 days ago
Critical Care Physician | Mercy Hospital St. Louis | St. Louis, Missouri
$250K - $300K *
Lead the charge in providing exceptional critical care for complex patients. Join a dynamic team at a tertiary teaching hospital, engaging in bedside care, education, and research while enjoying a sup...
5 days ago
$95K - $115K *
Drive innovation by deploying and troubleshooting advanced IP networks in diverse environments. Collaborate with teams to integrate cutting-edge security technologies while ensuring seamless connectiv...
Reposted 5 days ago
Senior Cloud Infrastructure Engineer
$120K - $145K *
Empower innovation by leading the design of scalable Azure cloud solutions. Drive automation, mentor engineers, and leverage AI to enhance infrastructure reliability and operational efficiency while c...
5 days ago
$110K - $130K *
Lead the charge in expanding our creator program internationally, recruiting and coaching creators to share impactful stories. Drive content development that showcases Trybe's value to both creators a...
5 days ago
$180K - $200K *
Shape the future of cybersecurity by leading product marketing initiatives that bridge product, sales, and market needs. Drive go-to-market strategies, create compelling narratives, and empower teams...
Reposted 5 days ago
Senior Compliance Associate, KYC
$95K - $115K *
Champion compliance excellence by managing KYC processes, assessing customer risk, and collaborating across teams to enhance operational efficiency and support junior analysts in a dynamic environment...
5 days ago
$107K - $134K *
Drive innovative actuarial pricing solutions by leading complex projects, enhancing filing processes, and collaborating cross-functionally to align technical insights with strategic goals in a dynamic...
5 days ago
$80K - $108K *
Join a team that's dedicated to enhancing member experiences through strategic lifecycle marketing. You'll design and execute campaigns that drive engagement and retention, collaborating cross-functio...
5 days ago
$140K - $160K *
Shape the future of finance by leading multiple hypergrowth companies simultaneously. Experience rapid professional growth while collaborating directly with client leadership teams, delivering strateg...
Reposted 5 days ago
$170K - $200K *
Drive the charge in advancing oncology therapies by engaging healthcare professionals, educating on treatment pathways, and executing marketing strategies to enhance patient access and awareness in a...
5 days ago
Account Executive - Southern California
$70K - $110K *
Accelerate account growth by driving new customer acquisition and managing key district partnerships in the K-12 education market, while delivering teletherapy solutions and ensuring exceptional custo...
Reposted 5 days ago
$146K - $172K *
Shape the future of air transportation by leading strategic initiatives, optimizing operations, and ensuring compliance in a dynamic logistics environment. Drive performance and client satisfaction wh...
5 days ago
HR Reinvention Consulting Senior Manager, Life Sciences
$94K - $293K *
Unlock the potential of HR transformation by leading strategic projects that integrate digital solutions and optimize processes. Collaborate with clients to enhance HR functions, driving business perf...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.