Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$59K - $177K *

Drive finance transformation in Life Sciences by enhancing processes, data, and technology. Collaborate with leaders to improve efficiency, manage costs, and identify opportunities, leveraging analyti...

5 days ago

  •   Less than 5 years exp.  •   Business Services

$122K - $292K *

Lead advanced analytics initiatives to transform data into actionable insights, driving strategic decisions across Brand and Consumer-focused projects. Collaborate with stakeholders to enhance busines...

5 days ago

  •   8 - 10 years exp.  •   Business Services

$73K - $182K *

Create impactful AI learning experiences by developing courses, labs, and assessments. Collaborate with experts to ensure technical accuracy and instructional quality, enabling learners to apply AI sk...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$122K - $292K *

Transform the finance landscape in Life Sciences by leading complex, multi-workstream transformations. Collaborate with CFOs to align financial strategies with business goals, leveraging advanced tech...

5 days ago

  •   8 - 10 years exp.  •   Business Services

$63K - $100K *

Lead the charge in optimizing care management for members with complex needs by assessing, developing, and coordinating tailored care plans. Collaborate with healthcare professionals to ensure effecti...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$69K - $125K *

Grow your career with a dynamic team designing substation protection and control projects for electric utilities. Engage in innovative solutions across voltages from 12kV to 500kV, enhancing your expe...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Technical Services

$154K - $278K *

Drive innovation in advanced maritime technologies, leading multidisciplinary teams to deliver cutting-edge solutions for critical defense missions. Oversee program execution, business development, an...

United StatesRemote

5 days ago

  •   15+ years exp.  •   Technical Services

$69K - $125K *

Optimize site deployment efforts by leading a team to ensure successful FAA NextGen Air Traffic control program implementations, coordinating activities, and maintaining schedules for multiple locatio...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Technical Services

$92K - $166K *

Join a team that's dedicated to managing waterfront modernization and maintenance for naval systems. Oversee diverse teams, coordinate complex schedules, and ensure compliance with technical and safet...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Technical Services

$92K - $166K *

Unlock potential by leading logistics analysis and execution for naval programs, ensuring effective support for maintenance, training, and compliance in a dynamic environment. Collaborate with diverse...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Technical Services

$68K - $93K *

Join a dynamic team to enhance enterprise security solutions, investigate incidents, and ensure robust protection against threats. Collaborate across teams to deliver effective security services and m...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$185K - $312K *

Transform the Agentic Platform as a Principal PM, leading AI agent development across teams. Shape technical direction, enhance developer experience, and ensure seamless integration for impactful cust...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$156K - $262K *

Drive innovation by architecting and developing full stack web applications, mentoring engineers, and ensuring high-quality solutions that enhance user experiences and operational efficiency across di...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$101K - $137K *

Support seamless operations in media relations and digital communications, collaborating with cross-functional teams to enhance external engagement initiatives and drive impactful results in a dynamic...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$124K - $167K *

Shape impactful HCP marketing strategies for obesity initiatives, collaborating across teams to develop promotional materials and campaigns that enhance customer engagement and support launch readines...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$78K - $126K *

Unlock potential by providing expert compliance advisory services to diverse organizations. Collaborate with clients to enhance grant management, internal controls, and operational effectiveness throu...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$285K - $385K *

Champion transformative People technology and operations, driving AI and automation to enhance employee experiences. Lead strategic initiatives, optimize systems, and ensure data integrity while foste...

RemoteRemote

5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $185K *

Contribute to building and maintaining scalable data infrastructure for a high-impact security platform. Collaborate with engineers to enhance tools and systems, ensuring efficient processing of trill...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Join a team that's dedicated to advancing clinical research by managing site relationships, ensuring compliance, and overseeing study protocols. Your expertise will drive site performance and enhance...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Manage the feasibility study process by adapting surveys, ensuring quality checks, and monitoring site engagement. Collaborate with teams to execute strategies and maintain effective communication thr...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform client relationships by managing subservicing deliverables, ensuring compliance, and enhancing reporting processes. Collaborate with vendors and internal teams to support client needs and dr...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$68K - $99K *

Unlock potential by driving sales of Hybrid Infrastructure services, expanding market presence, and managing the full sales lifecycle. Build relationships, identify opportunities, and collaborate with...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$86K - $119K *

Lead the charge in building and supporting enterprise data solutions that transform business requirements into scalable models, enhancing analytics and reporting capabilities across the organization...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$184K - $244K *

Lead the development and execution of innovative U.S. pricing and contracting strategies, integrating policy insights and market dynamics to ensure competitive positioning for in-line and pipeline ass...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$155K - $205K *

Join a team that's shaping the future of R&D strategy by analyzing complex challenges, developing actionable insights, and driving innovative initiatives across global research and development efforts...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.