Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$75K - $125K *

Launch your career in law by gaining courtroom experience and managing litigation. Collaborate with a dedicated team, handle new claims, and ensure compliance while supporting the firm's commitment to...

Reposted today

  •   Less than 5 years exp.  •   Legal & Accounting

$125K - $150K *

Champion strategic preconstruction initiatives across industrial sectors, leading estimating, budgeting, and design coordination. Collaborate with clients and stakeholders to ensure project success fr...

Today

  •   8 - 10 years exp.  •   Real Estate & Construction

$185K - $327K *

Unlock potential by leading security strategy and architecture, partnering with the CISO to enhance technical oversight and incident response. Drive secure practices across teams while mentoring engin...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Finance & Insurance

$127K - $223K *

Transform the way we communicate life insurance through compelling copy that captures attention and drives action. Collaborate with teams to create impactful Direct Mail and social media content that...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Lead integrated demand generation initiatives to drive pipeline growth, collaborating with Sales and Product Marketing to create impactful campaigns that enhance customer acquisition and expansion, wh...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Consumer Technology

$70K - $200K *

The Licensed Life Insurance Sales Agent will guide customers through the life insurance buying process, educating them on products and ensuring a transparent experience. This role involves engaging wi...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$195K - $235K *

Drive innovation in autonomous systems by building robust platforms for AI agents, ensuring seamless execution and user-friendly interfaces while tackling complex distributed systems challenges across...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $125K *

Unlock potential by leading the end-to-end revenue cycle in a high-growth environment. You will engage with customers, optimize billing processes, and ensure accurate revenue recognition, contributing...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$168K - $285K *

Drive product strategy for tenant scale and unified deployment across platforms, collaborating with engineering and product teams to enhance scalability and customer experience while mentoring peers a...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$114K - $172K *

Drive strategic growth by leading enterprise accounts in Chicago, guiding influential organizations through complex digital transformations with GitLab's AI-powered DevSecOps platform, and building lo...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$88K - $154K *

Explore a dynamic role in cyber network operations, developing tools that support national security missions. Collaborate with a skilled team to enhance software capabilities and contribute to critica...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$157K - $283K *

Lead the charge in managing transportation infrastructure projects, ensuring quality and efficiency while driving profitability and collaboration across teams to deliver successful outcomes for client...

RemoteRemote

Reposted today

  •   11 - 15 years exp.  •   Real Estate & Construction

$157K - $283K *

Lead the charge in managing large-scale transportation engineering projects, overseeing all phases from initiation to completion. Leverage your expertise to drive project success and ensure compliance...

United StatesRemote

Today

  •   15+ years exp.  •   Real Estate & Construction

$140K - $160K *

Drive the future of financial leadership by managing a dynamic accounting team, overseeing payroll, accounts payable, and general ledger accuracy while ensuring audit readiness and process improvement...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$145K - $155K *

Lead the charge in developing strategic grantmaking initiatives to decarbonize the U.S. electricity sector. Collaborate with grantees and stakeholders to drive impactful policies and ensure equitable...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Explore innovative banking solutions by bridging technology and business needs. Collaborate with sales and clients to design tailored solutions, ensuring successful adoption of digital banking platfor...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $105K *

Elevate brand identity by designing cohesive visual assets and systems. Collaborate cross-functionally to enhance marketing initiatives and ensure brand consistency across all platforms, driving recog...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $140K *

Join a team that's transforming higher education through ERP solutions. Lead strategy, governance, and optimization initiatives while managing a talented team to enhance operational performance and dr...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$120K - $145K *

Champion quality assurance initiatives by leveraging Python and AI-assisted practices. Drive automation improvements, enhance testing efficiency, and collaborate with cross-functional teams to elevate...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Unlock your potential as you deliver exceptional optometric care, utilizing advanced technology and working in a supportive environment, while enhancing patient outcomes through comprehensive eye exam...

Reposted today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$113K - $191K *

Empower innovation in safety technology by developing AI-driven solutions that enhance customer experiences and operational efficiency. Collaborate across teams to deliver scalable, impactful products...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$145K - $205K *

Champion leadership growth by designing impactful development programs for new and aspiring leaders. Drive engagement and skill-building through innovative learning experiences that foster high-perfor...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$81K - $99K *

Partner with us to guide new customers through onboarding, ensuring their success with our platforms. Collaborate with teams to develop strategies that enhance client engagement and support throughout...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$87K - $100K *

Unlock potential by leading complex WAN/LAN network solutions, mentoring IT staff, and driving technology decisions to enhance infrastructure security and reliability while tackling challenging techni...

Today

  •   8 - 10 years exp.  •   Information Technology

$110K - $145K *

Empower enterprise growth by managing high-value accounts in a dynamic SaaS environment. Drive the full sales cycle, build executive relationships, and navigate complex negotiations to achieve impactf...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.