Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $110K *

Discover a dynamic role where you'll enhance customer search experiences and backend systems. Collaborate across teams to deliver intuitive, AI-powered solutions while ensuring performance and reliabi...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Media

$116K - $243K *

Engage with cross-functional teams to deliver expert SAP S/4HANA FI/CO solutions, driving requirements, design, and deployment in a secure, classified aerospace environment. Contribute significantly t...

Reposted 4 days ago

  •   Less than 5 years exp.  •   Business Services

$103K - $196K *

Join a dynamic team as you design and implement SAP procurement solutions, enhancing complex procure-to-pay processes. Collaborate with cross-functional teams to ensure alignment with business needs a...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Business Services

$140K - $460K *

Champion renewable energy by managing complex energy storage projects. You'll lead multidisciplinary teams, oversee project scope, schedules, and budgets while driving innovation and efficiency from c...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $200K *

Discover innovative ways to engage audiences by leading voice and community strategies. Drive content standards, optimize performance with AI, and foster authentic connections across platforms while m...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Media

$125K - $150K *

Shape the future of enterprise solutions by leading D365 F&O implementations, guiding technical teams, and optimizing integrations. Leverage your extensive IT experience to deliver innovative architec...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$162K - $238K *

Design and optimize R&D operations to enhance organizational effectiveness through data-driven insights, collaboration, and governance. Partner cross-functionally to drive continuous improvement and e...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Information Technology

$117K - $206K *

Drive growth by selling predictive solutions, cultivating strong customer relationships, and consistently exceeding sales targets. Leverage your expertise to navigate complex sales cycles and close hi...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Take ownership of complex technical issues, driving resolution and enhancing customer experience through deep problem-solving and collaboration with cross-functional teams...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $120K *

Join a dedicated team to execute precision packaging processes for cutting-edge quantum hardware. You'll handle delicate components, operate complex equipment, and ensure quality through meticulous in...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$126K - $149K *

Join a team that drives innovation in credit risk management, overseeing strategic initiatives to optimize portfolio performance and mitigate risk, while collaborating with diverse stakeholders to fos...

Reposted 4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$105K - $120K *

Empower healthcare professionals by engaging remotely with cardiologists, nephrologists, and primary care providers. Drive sales and support efforts in open territories while delivering a consistent e...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $200K *

Champion commercial manufacturing excellence by leading technical operations, ensuring on-time delivery of drug products and APIs, and collaborating with regulatory teams to meet compliance and perfor...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Make your mark at a dynamic healthcare facility, providing essential pharmaceutical care, verifying medication orders, and collaborating with healthcare teams to enhance patient safety and treatment e...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$87K - $146K *

Lead the charge in ensuring accurate tax reporting for life insurance and retirement products. Collaborate across teams to implement regulatory changes, resolve issues, and enhance processes, driving...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Join our team to shape external developer experiences through impactful APIs and SDKs. You'll evolve documentation and tools while collaborating across teams to enhance our growing platform and delive...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive the future of technology services by leading IT operations, ensuring reliability, security, and performance across internal and client-facing environments. Collaborate with teams to enhance serv...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$190K - $230K *

Pioneer innovative mobile solutions by architecting and building a robust app experience. Collaborate with cross-functional teams to deliver impactful features while leveraging AI tools to enhance dev...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Join a team that's dedicated to enhancing railroad safety and efficiency. Lead project coordination, oversee engineering approvals, and foster partnerships with stakeholders to ensure successful deliv...

4 days ago

  •   5 - 7 years exp.  •   Transportation

$85K - $95K *

Join a team that's dedicated to financial analysis and strategic support, driving insights for monthly close processes and cross-functional collaboration. This role emphasizes independent analysis and...

4 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$140K - $170K *

Elevate enterprise growth by leading product strategy and branch optimization. Drive cross-functional initiatives, leveraging data insights to enhance customer value and operational efficiency across...

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Transform the future of product marketing by designing innovative go-to-market strategies, enhancing customer advocacy, and building scalable frameworks that drive growth and engagement in a dynamic B...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$88K - $105K *

Unlock potential by leading a dynamic team in domestic purchasing, optimizing inventory management, and enhancing supplier relationships to drive operational efficiency and customer satisfaction acros...

4 days ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Transform compliance in skilled nursing by leading regulatory strategy and product integration. Collaborate across teams to ensure operators meet federal and state standards, enhancing survey readines...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $115K *

Champion integrated media strategies for pharmaceutical clients, driving engagement and measurable outcomes. Lead cross-functional teams to develop innovative solutions that address complex healthcare...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.