Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$137K - $158K *
Shape the future of sales operations by driving analytics, improving processes, and enhancing cross-functional collaboration to support profitable growth and commercial excellence across the organizat...
5 days ago
$95K - $115K *
Elevate the Managed Services team by leading specialists in review response, social media, and listings management. Drive operational excellence, client satisfaction, and revenue growth while ensuring...
5 days ago
Healthcare Marketing Strategy Manager
$163K - $322K *
Join a dynamic team to deliver strategic marketing solutions tailored for Health Care clients. Lead engagements that drive measurable outcomes, leveraging insights and AI to transform marketing functi...
Reposted 5 days ago
Claims Advisor, Professional Liability | E&O, D&O
$115K - $130K *
Unlock potential by managing complex D&O, EPL, and E&O claims. Analyze, negotiate, and resolve claims while ensuring compliance and fostering client relationships. Lead investigations and mentor team...
5 days ago
Healthcare Marketing Strategy Manager
$163K - $322K *
Transform health care marketing through strategy consulting, leading teams to enhance client engagements and optimize performance across the CMO's agenda, driving measurable results in a dynamic envir...
Reposted 5 days ago
Director, Drug Safety Physician
$280K - $311K *
Optimize safety evaluations within our Drug Safety team to drive innovative strategies for monitoring and managing clinical risks, ensuring compliance and maintaining high-quality standards in pharmac...
Reposted 5 days ago
Senior Growth Marketing Manager, Lifecycle
$127K - $223K *
Lead the charge in optimizing user journeys for engagement and retention. Design multi-channel re-engagement strategies for high-value client interactions, focusing on maximizing long-term value throu...
Reposted 5 days ago
Writer/Content Designer, Conversion and Growth
$147K - $259K *
Collaborate with cross-functional teams to craft compelling content that simplifies complex financial decisions and enhances user experience, contributing to the evolution of content design standards...
Reposted 5 days ago
Senior Software Engineer, Partner Integrations
$199K - $235K *
Unlock potential by designing and maintaining integrations that connect NodeZero with key security platforms. Collaborate with teams to enhance reliability and observability, ensuring seamless user ex...
5 days ago
Senior Construction Project Manager
$100K - $120K *
Drive project success by managing estimates, schedules, and quality control. Collaborate with owners and design teams, oversee subcontractors, and ensure client satisfaction while mentoring junior pro...
5 days ago
$130K - $170K *
Transform data into actionable insights by analyzing EV telematics and charging patterns. Collaborate across teams to enhance data quality and drive product innovation, shaping the future of electric...
5 days ago
Software Engineer II, Fullstack (Capital Orchestration)
$146K - $206K *
Contribute to the development of a scalable platform ensuring liquidity for effective loan origination and vendor payments. Engage with cross-functional teams to design and implement user-friendly sys...
Reposted 5 days ago
$100K - $160K *
Lead the charge in driving security business growth by identifying opportunities, engaging prospects, and leveraging expertise to close deals. Collaborate with sales teams to enhance customer adoption...
5 days ago
Global Director of Transfer Pricing
$142K - $196K *
Join a team that's redefining global transfer pricing strategies. Lead compliance, governance, and advisory efforts while collaborating with cross-functional leaders to enhance operational efficiency...
Reposted 5 days ago
Account Executive - Attribute™, North America
$110K - $130K *
Accelerate growth by building a new region from scratch, driving sales, and establishing customer success stories for a groundbreaking FinOps solution. Own the full sales cycle, focusing on net-new lo...
5 days ago
Account Supervisor, Market Access
$90K - $115K *
Drive client satisfaction and project success as you lead teams, manage client relationships, and oversee project execution. Collaborate across departments to ensure quality and profitability while me...
5 days ago
Sponsor Dedicated Senior Medical Writer (Regulatory Submission Documents)- US Remote Based
$80K - $145K *
Lead the charge in delivering high-quality medical writing for regulatory submissions, collaborating with cross-functional teams to ensure clarity and compliance in clinical documentation while mentor...
5 days ago
HR Business Partner, U.S. Medical Device Services
$88K - $105K *
Join a team that's dedicated to enhancing employee engagement and organizational effectiveness. As a strategic HR partner, you'll align people strategies with business goals, drive talent development...
5 days ago
$80K - $95K *
Drive design excellence by leading a talented team, overseeing operations, and ensuring compliance with industry standards while fostering professional growth and collaboration across multiple locatio...
5 days ago
Renewals and Commercial Operations Manager
$110K - $130K *
Join a team that's driving customer success by optimizing renewal strategies and commercial operations. You'll lead contract negotiations, protect revenue, and enhance operational efficiency while col...
5 days ago
$95K - $115K *
Shape the future of defense programs by managing technology initiatives, supporting federal acquisitions, and driving business development efforts. Collaborate with diverse teams to translate complex...
5 days ago
$79K - $127K *
Empower your career by managing and optimizing critical DB2 databases, ensuring high availability and performance in a dynamic healthcare environment. Collaborate with teams to drive continuous improv...
Reposted 5 days ago
$99K - $115K *
Lead the charge in designing and coordinating mechanical systems for diverse projects. Ensure compliance, constructability, and alignment with client goals while managing documentation and client comm...
5 days ago
$96K - $111K *
Drive the administration and analysis of employee benefits programs, ensuring compliance and enhancing the associate experience. Collaborate with HR and external vendors to manage health, retirement...
5 days ago
$80K - $125K *
Lead innovative product marketing strategies to empower financial advisors. Collaborate cross-functionally to translate complex solutions into clear value propositions, driving adoption and enhancing...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.