Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$137K - $158K *

Shape the future of sales operations by driving analytics, improving processes, and enhancing cross-functional collaboration to support profitable growth and commercial excellence across the organizat...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Elevate the Managed Services team by leading specialists in review response, social media, and listings management. Drive operational excellence, client satisfaction, and revenue growth while ensuring...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$163K - $322K *

Join a dynamic team to deliver strategic marketing solutions tailored for Health Care clients. Lead engagements that drive measurable outcomes, leveraging insights and AI to transform marketing functi...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$115K - $130K *

Unlock potential by managing complex D&O, EPL, and E&O claims. Analyze, negotiate, and resolve claims while ensuring compliance and fostering client relationships. Lead investigations and mentor team...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$163K - $322K *

Transform health care marketing through strategy consulting, leading teams to enhance client engagements and optimize performance across the CMO's agenda, driving measurable results in a dynamic envir...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$280K - $311K *

Optimize safety evaluations within our Drug Safety team to drive innovative strategies for monitoring and managing clinical risks, ensuring compliance and maintaining high-quality standards in pharmac...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$127K - $223K *

Lead the charge in optimizing user journeys for engagement and retention. Design multi-channel re-engagement strategies for high-value client interactions, focusing on maximizing long-term value throu...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$147K - $259K *

Collaborate with cross-functional teams to craft compelling content that simplifies complex financial decisions and enhances user experience, contributing to the evolution of content design standards...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$199K - $235K *

Unlock potential by designing and maintaining integrations that connect NodeZero with key security platforms. Collaborate with teams to enhance reliability and observability, ensuring seamless user ex...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Drive project success by managing estimates, schedules, and quality control. Collaborate with owners and design teams, oversee subcontractors, and ensure client satisfaction while mentoring junior pro...

5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$130K - $170K *

Transform data into actionable insights by analyzing EV telematics and charging patterns. Collaborate across teams to enhance data quality and drive product innovation, shaping the future of electric...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$146K - $206K *

Contribute to the development of a scalable platform ensuring liquidity for effective loan origination and vendor payments. Engage with cross-functional teams to design and implement user-friendly sys...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $160K *

Lead the charge in driving security business growth by identifying opportunities, engaging prospects, and leveraging expertise to close deals. Collaborate with sales teams to enhance customer adoption...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Technical Services

$142K - $196K *

Join a team that's redefining global transfer pricing strategies. Lead compliance, governance, and advisory efforts while collaborating with cross-functional leaders to enhance operational efficiency...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Accelerate growth by building a new region from scratch, driving sales, and establishing customer success stories for a groundbreaking FinOps solution. Own the full sales cycle, focusing on net-new lo...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $115K *

Drive client satisfaction and project success as you lead teams, manage client relationships, and oversee project execution. Collaborate across departments to ensure quality and profitability while me...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $145K *

Lead the charge in delivering high-quality medical writing for regulatory submissions, collaborating with cross-functional teams to ensure clarity and compliance in clinical documentation while mentor...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Join a team that's dedicated to enhancing employee engagement and organizational effectiveness. As a strategic HR partner, you'll align people strategies with business goals, drive talent development...

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive design excellence by leading a talented team, overseeing operations, and ensuring compliance with industry standards while fostering professional growth and collaboration across multiple locatio...

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join a team that's driving customer success by optimizing renewal strategies and commercial operations. You'll lead contract negotiations, protect revenue, and enhance operational efficiency while col...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Shape the future of defense programs by managing technology initiatives, supporting federal acquisitions, and driving business development efforts. Collaborate with diverse teams to translate complex...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$79K - $127K *

Empower your career by managing and optimizing critical DB2 databases, ensuring high availability and performance in a dynamic healthcare environment. Collaborate with teams to drive continuous improv...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$99K - $115K *

Lead the charge in designing and coordinating mechanical systems for diverse projects. Ensure compliance, constructability, and alignment with client goals while managing documentation and client comm...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Technical Services

$96K - $111K *

Drive the administration and analysis of employee benefits programs, ensuring compliance and enhancing the associate experience. Collaborate with HR and external vendors to manage health, retirement...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $125K *

Lead innovative product marketing strategies to empower financial advisors. Collaborate cross-functionally to translate complex solutions into clear value propositions, driving adoption and enhancing...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.