Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$180K - $215K *

Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Leverage strong business acumen and collaborative skills to achieve sale...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Unlock regional growth by leading a high-performing sales team, executing launch strategies, and fostering key customer relationships in a dynamic, fast-paced environment. Drive performance and ensure...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$67K - $199K *

Unlock your potential as you design and develop impactful Power BI solutions, enhancing analytics capabilities and driving strategic decision-making in a dynamic sales environment. Collaborate with cr...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Join us to lead regional sales efforts, driving product launch success and team performance. You'll build strong customer relationships, execute strategic plans, and foster a high-performing culture i...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$98K - $163K *

Join a team that's dedicated to enhancing fraud risk assessments for digital services. You'll evaluate risks, identify fraud controls, and support ongoing assessments, ensuring timely delivery and eff...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$115K - $192K *

Drive your career with a dynamic legal role focused on AI and emerging technologies. Collaborate across teams to navigate evolving regulations, provide strategic guidance, and support responsible inno...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$106K - $176K *

Champion operational excellence by leading clinical program advisors and analysts. Drive custom client implementations and specialty programs while enhancing process optimization and governance across...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$103K - $171K *

Bring your expertise to support advanced mechanical systems design for cutting-edge weapon programs. Collaborate across disciplines to ensure safety, reliability, and rapid prototyping in unique envir...

5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Champion innovative solutions by guiding enterprise clients through discovery, demos, and implementation. Leverage technical expertise and business acumen to ensure successful deployment and measurabl...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $160K *

Elevate financial planning and analysis as you lead consolidated forecasts, enhance reporting quality, and partner with executives to drive strategic decisions. Utilize AI and automation to optimize p...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$200K *

Champion new business growth by driving strategic sales initiatives, expanding market share, and fostering relationships within the parking management and mobility sectors. Leverage expertise to close...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Transportation

$166K - $195K *

Empower customer experience by leading high-value trading support initiatives, aligning cross-functional strategies, and enhancing service delivery for key trading customers while driving retention th...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $90K *

Champion impactful learning initiatives by assessing needs, designing solutions, and leading projects from inception to evaluation. Collaborate with stakeholders to enhance employee performance and dr...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Help us redefine automation by deploying and maintaining advanced robotic systems. Collaborate across disciplines to ensure optimal performance and customer satisfaction while traveling extensively to...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K - $115K *

Unlock potential by leading strategic enterprise partnerships, orchestrating cross-functional initiatives, and driving growth for complex, multi-million dollar accounts. Foster executive engagement an...

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $115K *

Accelerate progress at the forefront of enterprise partnerships, driving strategic alignment and growth for complex, seven-figure accounts. Lead cross-functional teams to enhance partner retention and...

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$148K - $263K *

Champion innovative financial solutions by leading complex OneStream implementations. Collaborate with teams to design scalable architectures, optimize performance, and ensure high-quality deliverable...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$140K - $175K *

Lead transformative insurance program initiatives, overseeing technology enhancements and operational workflows. Collaborate across teams to drive project management and ensure compliance, while optim...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Lead the design and implementation of scalable ML systems, bridging business strategy with technical execution. Drive impactful data solutions, mentor teams, and ensure robust model performance to enh...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Transform business workflows by leading the development of low-code AI products that enhance efficiency and deliver measurable outcomes. Collaborate with teams to identify needs, validate solutions, a...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $180K *

Lead the coordination of joint sales initiatives with Adobe for strategic clients. Ensure efficient collaboration among teams, manage project execution, and foster strong relationships to drive operat...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Media

$500K+*

Lead the charge in developing a next-gen AI/ML serving and inference platform. Collaborate with cross-functional teams to architect scalable solutions that empower ML practitioners across diverse doma...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$137K - $158K *

Shape the future of sales operations by driving analytics, improving processes, and enhancing cross-functional collaboration to support profitable growth and commercial excellence across the organizat...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Elevate the Managed Services team by leading specialists in review response, social media, and listings management. Drive operational excellence, client satisfaction, and revenue growth while ensuring...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$163K - $322K *

Join a dynamic team to deliver strategic marketing solutions tailored for Health Care clients. Lead engagements that drive measurable outcomes, leveraging insights and AI to transform marketing functi...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.