Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Manager of Board Relations & Special Projects
$85K - $90K *
Manage board relations and special projects, ensuring effective communication and support for the Executive Director. Collaborate across teams to execute organizational priorities and enhance governan...
Reposted 5 days ago
$81K - $129K *
Partner with us to drive project excellence across the Americas by managing upgrade planning and costing, ensuring high standards in productivity, customer satisfaction, and operational metrics throug...
5 days ago
Senior Advisor, Clinical Science (remote)
$153K - $268K *
Transform clinical science in late-stage trials for innovative sleep/wake therapies. Collaborate cross-functionally to ensure compliance, drive recruitment, and deliver high-quality results while shap...
Reposted 5 days ago
$80K - $90K *
Transform the IT landscape by enhancing cloud services and user systems. Play a key role in optimizing platforms like Azure, O365, and Jira, while driving efficiencies through automation and collabora...
Reposted 5 days ago
Sales Executive Lead, Enterprise Platforms - Ledger
$133K - $227K *
Empower financial institutions by strategizing and executing innovative ledger solutions. Engage with C-suite executives to drive modernization and enhance operational resilience, while managing the f...
5 days ago
$125K - $150K *
Grow your career with an innovative startup, driving strategic enterprise deals and cultivating key relationships with Fortune 1000 executives to showcase cutting-edge AI technology and deliver except...
Reposted 5 days ago
$180K - $240K *
Innovate by bridging software engineering and customer delivery, shaping core product capabilities while deploying AI solutions. Collaborate with teams to translate needs into robust systems, ensuring...
5 days ago
$99K *
Join a team that's dedicated to enhancing patient engagement through virtual education and support. Provide compassionate care navigation and build relationships with patients and caregivers throughou...
5 days ago
Traveling MEP Superintendent - Data Centers
$135K - $185K *
Lead and coordinate mechanical and electrical systems for advanced technology projects. Ensure safety, quality, and budget adherence while managing subcontractors and trade labor. Drive project succes...
5 days ago
Solution Architect - ArcGIS Enterprise | TS/SCI
$120K - $197K *
Drive innovation by architecting enterprise-scale ArcGIS solutions, designing secure deployment architectures, and guiding modernization strategies. Collaborate with clients to develop technology road...
Reposted 5 days ago
Sr. GIS Account Manager - Utilities, Telecom, Rail
$114K - $218K *
Transform customer relationships by driving innovative geospatial strategies for large infrastructure organizations. Collaborate with teams to optimize Esri technology adoption, identify growth opport...
Reposted 5 days ago
$200K - $230K *
Unlock the potential of innovative products by partnering with technical teams to design and deliver exceptional customer experiences in a dynamic, regulated environment. Your expertise will shape com...
Reposted 5 days ago
$70K - $110K *
Elevate customer solutions by developing advanced analytics and machine learning systems. Collaborate with clients to address business challenges, implement best practices, and stay ahead of technolog...
5 days ago
Associate Customer Solutions Manager
$90K - $130K *
Drive customer success by managing onboarding, project delivery, and ongoing support. Collaborate with cross-functional teams to enhance the customer experience and ensure long-term account growth in...
Reposted 5 days ago
$160K - $210K *
Join a team that's redefining healthcare by crafting compelling product narratives, shaping go-to-market strategies, and driving growth in mid-market and enterprise segments through innovative marketi...
Reposted 5 days ago
Project Manager - Federal Programs (TS/SCI)
$84K - $142K *
Lead the charge in delivering geospatial solutions for federal clients. Manage project scope, schedule, and budget while collaborating with cross-functional teams to translate complex requirements int...
Reposted 5 days ago
$80K - $95K *
Take ownership of revenue modeling and forecasting, leveraging AI to automate processes and enhance reporting accuracy. Collaborate across functions to drive financial insights and support strategic d...
5 days ago
SAP S/4HANA Procurement Functional Lead - 100% onsite in St. Louis, MO
$124K - $246K *
Unlock your potential by leading SAP functional teams to deliver innovative solutions, ensuring alignment with business goals while fostering collaboration and continuous improvement across projects...
Reposted 5 days ago
$92K - $188K *
Deliver comprehensive SAP PS solutions by leading design, configuration, and support efforts for federal clients. Collaborate with cross-functional teams to ensure seamless integration and effective p...
Reposted 5 days ago
$120K - $145K *
Join a team that's shaping the future of Oracle Cloud solutions. As a key architect, you'll design and implement innovative Oracle CX applications, ensuring alignment with business goals while leading...
Reposted 5 days ago
Senior Oncology Account Specialist Hematology Detroit South, MI
$108K - $250K *
Elevate your career by driving oncology sales, promoting top-tier products, and enhancing healthcare provider relationships to improve patient outcomes and access within key accounts. Be a pivotal for...
Reposted 5 days ago
Gastroenterology Health & Science Specialist - Kansas City , KS
$108K - $250K *
Transform healthcare by driving GI product growth through strategic relationships and effective customer engagement. Collaborate with cross-functional teams to enhance patient access and achieve busin...
5 days ago
Product Lead, Predictive Platform
$188K - $255K *
Join a team that's empowering predictive modeling excellence. Lead and scale a product management pod while owning the core predictive foundation and driving transformative modeling initiatives in a h...
Reposted 5 days ago
Associate Director, Paid Search
$108K - $118K *
Lead the charge in shaping innovative SEM strategies, managing a dynamic team, and driving impactful campaigns for diverse clients. Collaborate with stakeholders to optimize performance and achieve bu...
5 days ago
Senior Facets Technical Consultant - Batch & Database Performance | Remote | 6+ Months
$120K - $145K *
Analyze and optimize high-volume Facets batch processing and SQL workloads. Collaborate with cross-functional teams to enhance performance, reduce processing times, and ensure production stability thr...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.