Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$85K - $90K *

Manage board relations and special projects, ensuring effective communication and support for the Executive Director. Collaborate across teams to execute organizational priorities and enhance governan...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$81K - $129K *

Partner with us to drive project excellence across the Americas by managing upgrade planning and costing, ensuring high standards in productivity, customer satisfaction, and operational metrics throug...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$153K - $268K *

Transform clinical science in late-stage trials for innovative sleep/wake therapies. Collaborate cross-functionally to ensure compliance, drive recruitment, and deliver high-quality results while shap...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $90K *

Transform the IT landscape by enhancing cloud services and user systems. Play a key role in optimizing platforms like Azure, O365, and Jira, while driving efficiencies through automation and collabora...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$133K - $227K *

Empower financial institutions by strategizing and executing innovative ledger solutions. Engage with C-suite executives to drive modernization and enhance operational resilience, while managing the f...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Grow your career with an innovative startup, driving strategic enterprise deals and cultivating key relationships with Fortune 1000 executives to showcase cutting-edge AI technology and deliver except...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $240K *

Innovate by bridging software engineering and customer delivery, shaping core product capabilities while deploying AI solutions. Collaborate with teams to translate needs into robust systems, ensuring...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$99K *

Join a team that's dedicated to enhancing patient engagement through virtual education and support. Provide compassionate care navigation and build relationships with patients and caregivers throughou...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$135K - $185K *

Lead and coordinate mechanical and electrical systems for advanced technology projects. Ensure safety, quality, and budget adherence while managing subcontractors and trade labor. Drive project succes...

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $197K *

Drive innovation by architecting enterprise-scale ArcGIS solutions, designing secure deployment architectures, and guiding modernization strategies. Collaborate with clients to develop technology road...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$114K - $218K *

Transform customer relationships by driving innovative geospatial strategies for large infrastructure organizations. Collaborate with teams to optimize Esri technology adoption, identify growth opport...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $230K *

Unlock the potential of innovative products by partnering with technical teams to design and deliver exceptional customer experiences in a dynamic, regulated environment. Your expertise will shape com...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$70K - $110K *

Elevate customer solutions by developing advanced analytics and machine learning systems. Collaborate with clients to address business challenges, implement best practices, and stay ahead of technolog...

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $130K *

Drive customer success by managing onboarding, project delivery, and ongoing support. Collaborate with cross-functional teams to enhance the customer experience and ensure long-term account growth in...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$160K - $210K *

Join a team that's redefining healthcare by crafting compelling product narratives, shaping go-to-market strategies, and driving growth in mid-market and enterprise segments through innovative marketi...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$84K - $142K *

Lead the charge in delivering geospatial solutions for federal clients. Manage project scope, schedule, and budget while collaborating with cross-functional teams to translate complex requirements int...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Take ownership of revenue modeling and forecasting, leveraging AI to automate processes and enhance reporting accuracy. Collaborate across functions to drive financial insights and support strategic d...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$124K - $246K *

Unlock your potential by leading SAP functional teams to deliver innovative solutions, ensuring alignment with business goals while fostering collaboration and continuous improvement across projects...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$92K - $188K *

Deliver comprehensive SAP PS solutions by leading design, configuration, and support efforts for federal clients. Collaborate with cross-functional teams to ensure seamless integration and effective p...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Join a team that's shaping the future of Oracle Cloud solutions. As a key architect, you'll design and implement innovative Oracle CX applications, ensuring alignment with business goals while leading...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Staffing

$108K - $250K *

Elevate your career by driving oncology sales, promoting top-tier products, and enhancing healthcare provider relationships to improve patient outcomes and access within key accounts. Be a pivotal for...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$108K - $250K *

Transform healthcare by driving GI product growth through strategic relationships and effective customer engagement. Collaborate with cross-functional teams to enhance patient access and achieve busin...

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$188K - $255K *

Join a team that's empowering predictive modeling excellence. Lead and scale a product management pod while owning the core predictive foundation and driving transformative modeling initiatives in a h...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$108K - $118K *

Lead the charge in shaping innovative SEM strategies, managing a dynamic team, and driving impactful campaigns for diverse clients. Collaborate with stakeholders to optimize performance and achieve bu...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Analyze and optimize high-volume Facets batch processing and SQL workloads. Collaborate with cross-functional teams to enhance performance, reduce processing times, and ensure production stability thr...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.