Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$160K - $200K *

Join a team that's redefining financing experiences by leading product strategy and execution for Originations. Drive growth through innovative apply and checkout solutions while collaborating across...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$127K - $224K *

Drive impactful product modeling and marketing measurement as a Staff Data Scientist. Own the lifecycle of ML models, collaborate with PMs, and communicate insights effectively to enhance user experie...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$96K - $169K *

Engineer robust Salesforce applications and integrations, driving full-lifecycle development from design to deployment. Collaborate with cross-functional teams to enhance sales and service tools, ensu...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$83K - $147K *

Join a team that's shaping the future of sales training by architecting and delivering innovative programs for agents. Collaborate with leaders to enhance strategies, improve performance, and drive ex...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$165K - $292K *

Shape the future of user experience by leading design across multiple products. In this strategic role, you will influence a team of designers, drive innovative product development, and elevate design...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$147K - $293K *

Lead the charge in building delightful digital experiences for life insurance consumers, advocating user needs while driving strong business growth through innovative product management and data-drive...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$123K - $217K *

Drive your career with impactful cross-functional programs, leading initiatives from planning to launch. Collaborate with diverse teams to navigate complexity, ensuring successful delivery and continu...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$139K - $235K *

Lead the development of innovative CX solutions using AI tools, enhancing workflows and integrations across platforms. Collaborate with cross-functional teams to deliver production-quality software an...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$183K - $323K *

Lead design initiatives to transform user journeys into intuitive experiences ensuring clarity, engagement, and conversion. Collaborate across teams to elevate design excellence and mentor talented de...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Shape the future of enterprise sales by driving innovation and closing deals. Collaborate with key stakeholders to expand customer vision and exceed revenue targets while managing complex sales cycles...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$215K - $307K *

Lead the charge in designing and evolving global cloud infrastructure, leveraging deep Azure expertise to build secure, scalable systems that enhance enterprise SaaS platforms and improve developer ex...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $200K *

Join a team that's redefining cloud operations by leading a unified infrastructure organization. Drive platform reliability, cost efficiency, and operational excellence while collaborating with cross...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$215K - $408K *

Drive medical management and quality improvement initiatives, ensuring effective utilization and cost containment while collaborating with clinical teams to enhance patient care and outcomes across mu...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$134K - $249K *

Unlock potential by leading enterprise-wide third party risk management, ensuring compliance and oversight across healthcare functions. Drive strategic direction, governance, and risk frameworks while...

Missouri, USRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Inspire growth by driving enterprise partnerships in healthcare. Leverage your sales expertise to lead complex cycles, build relationships with C-suite stakeholders, and shape strategic initiatives in...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Lead and develop dynamic engineering teams to enhance communication systems that improve health equity outcomes for underserved patients. Drive technical direction, manage shared codebases, and collab...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$151K - $205K *

Unlock potential by leading Local Study Operations, managing clinical trial portfolios, ensuring alignment with global strategies, and fostering a high-performance environment focused on continuous im...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in implementing enterprise software solutions in healthcare, coordinating cross-functional teams to ensure compliance with financial and PCI standards while driving project success and...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Grow your career with a dynamic role focused on expanding strategic accounts in healthcare. Drive sales, enhance customer relationships, and lead initiatives to meet objectives while collaborating wit...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K *

Champion marketing analytics to drive insights and improve enrollment performance. Collaborate with teams to evaluate marketing effectiveness, optimize strategies, and enhance decision-making through...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Accelerate growth by leading innovative marketing strategies that drive customer expansion and partner engagement. Collaborate cross-functionally to create data-driven campaigns that enhance retention...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$118K - $216K *

Lead the development of innovative ad solutions for a high-traffic mobile app, enhancing user experience while driving revenue. Collaborate with cross-functional teams to implement AI-driven workflows...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $90K *

Manage board relations and special projects, ensuring effective communication and support for the Executive Director. Collaborate across teams to execute organizational priorities and enhance governan...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$81K - $129K *

Partner with us to drive project excellence across the Americas by managing upgrade planning and costing, ensuring high standards in productivity, customer satisfaction, and operational metrics throug...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$153K - $268K *

Transform clinical science in late-stage trials for innovative sleep/wake therapies. Collaborate cross-functionally to ensure compliance, drive recruitment, and deliver high-quality results while shap...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.