Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$172K - $269K *

Lead and modernize global security operations, managing a distributed team while enhancing detection strategies and incident response. Drive AI integration for efficiency and ensure accountability thr...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$179K - $280K *

Shape the future of product marketing by leading a dynamic team focused on innovation, market resonance, and compelling narratives to drive product adoption and growth in a fast-paced environment...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$253K - $342K *

Join a team that's redefining pricing and packaging strategies to drive customer value and profitable growth. Lead cross-functional collaboration and influence key decisions that shape the future of m...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Lead the administration of diverse ETFs, ensuring compliance and accuracy while mentoring a team. Collaborate cross-functionally to enhance operational processes and support fund operations in a dynam...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$85K - $110K *

Collaborate with cross-functional teams to manage ETF fund administration, ensuring compliance with SEC regulations while preparing financial statements and regulatory filings. Adapt to evolving prior...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $207K *

Develop and document global accounting processes, support SAP S/4HANA implementation, and ensure compliance with accounting standards while collaborating with cross-functional teams to enhance financi...

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$120K - $207K *

Lead the charge in transforming global finance processes by documenting, testing, and validating SAP S/4HANA implementations. Collaborate with cross-functional teams to ensure compliance and optimize...

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $150K *

Empower a safe work environment by leading industrial hygiene projects, ensuring compliance, and fostering team growth. Utilize your expertise to address health and safety issues while mentoring staff...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$180K - $200K *

Elevate your career by driving growth strategies that enhance lead generation for multiple brands. Collaborate with cross-functional teams to optimize acquisition channels and improve conversion rates...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $110K *

Help us shape the future of infrastructure by leveraging your cost estimating expertise in a collaborative, multi-disciplinary team, empowering positive community impact through precise project contro...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Technical Services

$190K - $215K *

Elevate your career by leading the development of AI-enabled Medical Information strategies. Drive high-quality responses, oversee scientific content, and collaborate cross-functionally to ensure laun...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $161K *

Shape the future of power systems engineering by leading advanced studies, consulting, and technology initiatives. Collaborate with utilities and industry organizations to tackle complex challenges an...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$186K *

Unlock potential by leading the design and delivery of innovative risk systems, optimizing fraud detection and mitigation processes, and mentoring engineers to enhance operational excellence in a dyna...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in optimizing our Epic systems as a Senior Application Advisor, guiding a dedicated team in enhancing patient access and delivering exceptional service to clients while fostering colla...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $237K *

Join a dynamic team to design and deploy cutting-edge machine learning models that enhance personalization and recommendations, driving impactful solutions across diverse datasets and collaborating wi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$130K - $150K *

Empower our cybersecurity initiatives by providing strategic leadership and ensuring compliance with DoD standards. Drive enterprise-level security architecture and risk management across multiple Tas...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$130K - $155K *

Lead the charge in shaping secure software development practices by architecting an innovative CI/CD-integrated AI code evaluation harness to enhance application security and developer trust while ens...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Partner with us to enhance digital operational resiliency by implementing strategies for business continuity and disaster recovery. Collaborate across teams to assess risks, design resilient architect...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$350K - $400K *

Optimize enterprise sales growth by leading a high-performing team, refining strategies, and driving revenue. Collaborate across departments to enhance processes and ensure long-term success in a dyna...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate your career by driving HR strategies that align with corporate goals. Collaborate with leaders to enhance organizational effectiveness, support talent management, and foster a high-performance...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Unlock new revenue streams by cultivating partnerships and driving sales growth through effective channel management and collaboration with internal teams in a dynamic environment...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Join a team that's transforming healthcare with AI solutions. Drive full-cycle sales, engage decision-makers, and exceed quotas while improving patient access and operational efficiency in dental and...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Transform your sales career by engaging mid-sized businesses with cutting-edge insights. Drive data-driven decisions and close deals while leveraging innovative tools in a dynamic, supportive environm...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Unlock potential by managing environmental assessments across diverse projects. Collaborate with clients and lead fieldwork while ensuring quality control and effective communication throughout the pr...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$163K - $369K *

Lead the migration and modernization practice for mid-market companies, defining strategy, ensuring quality, and driving revenue growth through innovative AWS solutions. Foster talent and build market...

Reposted 5 days ago

  •   11 - 15 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.