Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$114K - $172K *

Drive strategic growth by leading enterprise accounts in Chicago, guiding influential organizations through complex digital transformations with GitLab's AI-powered DevSecOps platform, and building lo...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$88K - $154K *

Explore a dynamic role in cyber network operations, developing tools that support national security missions. Collaborate with a skilled team to enhance software capabilities and contribute to critica...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$157K - $283K *

Lead the charge in managing transportation infrastructure projects, ensuring quality and efficiency while driving profitability and collaboration across teams to deliver successful outcomes for client...

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Reposted today

  •   11 - 15 years exp.  •   Real Estate & Construction

$157K - $283K *

Lead the charge in managing large-scale transportation engineering projects, overseeing all phases from initiation to completion. Leverage your expertise to drive project success and ensure compliance...

United StatesRemote

Today

  •   15+ years exp.  •   Real Estate & Construction

$140K - $160K *

Drive the future of financial leadership by managing a dynamic accounting team, overseeing payroll, accounts payable, and general ledger accuracy while ensuring audit readiness and process improvement...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$145K - $155K *

Lead the charge in developing strategic grantmaking initiatives to decarbonize the U.S. electricity sector. Collaborate with grantees and stakeholders to drive impactful policies and ensure equitable...

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Reposted today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Explore innovative banking solutions by bridging technology and business needs. Collaborate with sales and clients to design tailored solutions, ensuring successful adoption of digital banking platfor...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $105K *

Elevate brand identity by designing cohesive visual assets and systems. Collaborate cross-functionally to enhance marketing initiatives and ensure brand consistency across all platforms, driving recog...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $140K *

Join a team that's transforming higher education through ERP solutions. Lead strategy, governance, and optimization initiatives while managing a talented team to enhance operational performance and dr...

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Reposted today

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$120K - $145K *

Champion quality assurance initiatives by leveraging Python and AI-assisted practices. Drive automation improvements, enhance testing efficiency, and collaborate with cross-functional teams to elevate...

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Reposted today

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Unlock your potential as you deliver exceptional optometric care, utilizing advanced technology and working in a supportive environment, while enhancing patient outcomes through comprehensive eye exam...

Reposted today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$113K - $191K *

Empower innovation in safety technology by developing AI-driven solutions that enhance customer experiences and operational efficiency. Collaborate across teams to deliver scalable, impactful products...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$145K - $205K *

Champion leadership growth by designing impactful development programs for new and aspiring leaders. Drive engagement and skill-building through innovative learning experiences that foster high-perfor...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$81K - $99K *

Partner with us to guide new customers through onboarding, ensuring their success with our platforms. Collaborate with teams to develop strategies that enhance client engagement and support throughout...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$87K - $100K *

Unlock potential by leading complex WAN/LAN network solutions, mentoring IT staff, and driving technology decisions to enhance infrastructure security and reliability while tackling challenging techni...

Today

  •   8 - 10 years exp.  •   Information Technology

$110K - $145K *

Empower enterprise growth by managing high-value accounts in a dynamic SaaS environment. Drive the full sales cycle, build executive relationships, and navigate complex negotiations to achieve impactf...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$110K - $166K *

Lead the charge in end-to-end UX design for digital products, collaborating with cross-functional teams to deliver customer-centered solutions that enhance satisfaction and drive business results acro...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$153K *

Shape strategic transactions as the Deal Desk lead for North America, collaborating with Sales and cross-functional teams to enhance deal structure, execution, and compliance while optimizing processe...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$180K - $220K *

Join a team that's transforming healthcare by integrating innovative solutions with partners. Collaborate closely with technical teams to deliver seamless integrations and enhance user experiences fro...

United StatesRemote

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  •   5 - 7 years exp.  •   Healthcare

$134K - $249K *

Shape the future of vendor management by leading strategic partnerships, ensuring compliance, and optimizing performance across dental, vision, pharmacy, and transportation services, all while managin...

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  •   8 - 10 years exp.  •   Healthcare

$160K - $230K *

Join a team that's redefining product engineering by owning high-impact areas from concept to launch. Collaborate closely with leadership to enhance user experiences and drive innovation in a fast-pac...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Drive strategic business development initiatives in Electronic Warfare, expanding market presence and fostering relationships with US DoD customers. Leverage expertise to identify opportunities, gener...

United StatesRemote

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  •   8 - 10 years exp.  •   Aerospace & Defense

$80K - $95K *

Join a dynamic team as a technical liaison, driving innovative solutions and enhancing customer satisfaction through expert application engineering and sales support across diverse industrial systems...

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  •   Less than 5 years exp.  •   Manufacturing & Automotive

$68K - $107K *

Champion the administration of clinical trials by managing documentation, supplies, and regulatory submissions. Collaborate with cross-functional teams to ensure timely site readiness and compliance w...

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  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead and manage design-build projects, ensuring timely completion within budget while meeting client objectives and contractual obligations. Oversee scope development, financial performance, and compl...

United StatesRemote

Reposted today

  •   15+ years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.