Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $95K *

Join a dynamic team as a Growth Copywriter, driving impactful messaging strategies through data-driven experimentation and empathetic communication to enhance women's health access and retention...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $124K *

Unlock insights and drive efficiency by providing analytical support to Business Development. Collaborate cross-functionally to enhance reporting, streamline processes, and ensure data integrity, empo...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$133K - $200K *

Accelerate clinical data management processes by leading data entry, ensuring quality, and overseeing database development for clinical trials. Collaborate with cross-functional teams to meet project...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$87K - $116K *

Join a team that's dedicated to guiding customers through their deployment journey, ensuring seamless transitions and successful outcomes. Leverage your expertise to manage complex projects and collab...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$144K - $206K *

Join a team that's shaping the future of event marketing by leading strategic initiatives, optimizing national events, and enhancing customer engagement through innovative programs and partnerships th...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Healthcare

$125K - $150K *

Lead the charge in optimizing healthcare payer systems by leveraging your expertise in Facets configuration and workflow analysis. Collaborate with cross-functional teams to design and implement scala...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Transform your career by assisting multi-state companies with state and local tax compliance, planning, and controversies. Collaborate with a dynamic team to deliver expert advice and build strong cli...

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$78K - $118K *

Transform operational analytics by creating impactful performance metrics, diagnosing trends, and collaborating with cross-functional teams to optimize claims processes and drive continuous improvemen...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Accelerate progress at driving new-business growth through strategic channel partnerships. This role involves managing partner relationships, executing sales strategies, and influencing outcomes to ac...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's driving revenue growth by managing strategic corporate healthcare accounts, optimizing client satisfaction, and delivering measurable outcomes through expert relationship-building a...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $138K *

Empower your career by leading accounts receivable operations, optimizing cash flow, and enhancing team performance. Drive strategic initiatives, ensure compliance, and collaborate cross-functionally...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Advance your career by driving sales strategies in the pharmaceutical sector. Engage with healthcare professionals to deliver impactful presentations and optimize customer relationships while achievin...

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in managing complex technical projects across IT, Security, and Compliance. Engage with customers to translate technical needs into actionable plans while ensuring seamless internal co...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $155K *

Lead the charge in managing and expanding environmental investigation and remediation projects, ensuring technical excellence, client satisfaction, and regulatory compliance while fostering strong cli...

4 days ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $166K *

Lead the clinical data management process, ensuring quality and compliance from study startup to database lock. Collaborate with teams to develop databases, oversee data integrity, and train personnel...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$133K - $200K *

Drive excellence in clinical data management by overseeing data processes, ensuring quality, and leading cross-functional teams to deliver timely and accurate results throughout the clinical trial lif...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Reimagine higher education processes by leveraging your expertise in Ellucian Colleague Registration and Records. Collaborate with institutions to enhance student enrollment services and optimize work...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$138K - $171K *

Transform procurement strategies and supply chain solutions to meet customer needs. Lead negotiations, ensure compliance, and drive organizational improvements while collaborating with stakeholders to...

4 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$90K - $110K *

Drive success by partnering with colleges to optimize their Ellucian Colleague ERP systems, ensuring effective application design, configuration, and support while adhering to client budgets and timel...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$200K - $240K *

Innovate the future of legal support in a fast-paced environment, managing key commercial agreements and navigating regulatory challenges across various sectors. You'll drive legal strategy, enhance i...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Technical Services

$225K - $305K *

Create a robust security compliance program that ensures customer trust and regulatory readiness. Lead a global team, design controls, manage audits, and integrate AI-driven solutions to address diver...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Champion the design systems for institutional and consumer products, ensuring precision and accessibility. Collaborate closely with engineers to deliver high-quality components and documentation, driv...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$165K - $297K *

Drive strategic growth by leading capture efforts for large federal contracts. Collaborate with senior leaders to develop winning strategies and engage clients effectively. This remote role requires s...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Join a dynamic team to drive channel sales and co-sell strategies with leading AI partners. Leverage your expertise to build relationships, identify opportunities, and lead teams to close deals, all w...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Execute go-to-market strategies for product releases, translating technical features into compelling narratives. Collaborate with cross-functional teams to enhance customer engagement and maintain hig...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.