Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Unlock your potential by providing expert advisory in complex debt solutions for commercial banking clients. Collaborate with teams to deliver integrated strategies, manage credit processes, and mento...

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$107K - $180K *

Manage and deliver strategic communications for litigation and regulatory matters. Collaborate with Legal and C-suite peers, ensuring alignment between legal strategy and public voice while leading cr...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$186K - $314K *

Unlock your potential as a Senior Manager of Product Design, leading a team to refine visual identity and enhance customer experiences. Collaborate across teams to drive quality and innovation in digi...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $130K *

Elevate your career by leading impactful events that enhance visibility and engagement. Collaborate cross-functionally to develop strategic relationships and deliver high-quality experiences at confer...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Empower teams by building internal tools and automations to enhance support efficiency, diagnose issues, and collaborate with product and engineering for improved platform usability and customer exper...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$88K - $105K *

Lead the design and execution of complex structural systems, mentoring junior engineers while collaborating with multidisciplinary teams to ensure project success and adherence to deadlines...

4 days ago

  •   8 - 10 years exp.  •   Technical Services

$80K - $95K *

Engineer innovative solutions as a Project Engineer, overseeing diverse projects from design to execution. Collaborate with teams to ensure quality standards and effective communication, driving conti...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Technical Services

$85K - $100K *

Optimize clinical trial execution by managing site relationships, ensuring compliance, and safeguarding patient safety. Play a key role in monitoring, training, and resolving issues to enhance study q...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Accelerate progress at joint ventures with health systems, leading complex transactions from engagement to execution. Drive growth through partnerships, leveraging strategic relationships and operatio...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$136K - $170K *

Transform patient access by leading reimbursement initiatives and collaborating with cross-functional teams to maximize the reach of innovative healthcare technologies while ensuring compliance and ed...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $102K *

Elevate your career by managing day-to-day financial operations, ensuring compliance, and supporting strategic financial initiatives. Collaborate with diverse teams to maintain financial health and dr...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$85K - $95K *

Drive the end-to-end delivery of complex curriculum projects, collaborating across teams to ensure high-quality outcomes that meet business and learner needs while managing risks and stakeholder expec...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$90K - $130K *

Drive strategic partnerships by leading the sales cycle for hospital systems. Engage C-suite executives to negotiate complex agreements, enhancing operational efficiency and revenue retention in wound...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$136K - $185K *

Pioneer innovative underwriting solutions while building strong client relationships. Collaborate with teams to assess complex risks and provide strategic guidance, ensuring exceptional service and co...

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$119K - $186K *

Lead the charge in delivering strategic legal counsel for complex corporate transactions, managing M&A processes globally, and ensuring effective collaboration across departments to drive business suc...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$176K - $281K *

Empower your career by leading complex service portfolios, driving strategic initiatives, and delivering measurable value through innovative solutions in a dynamic environment. Collaborate across team...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$73K - $132K *

Grow your career with a dynamic team solving complex challenges in electric transmission design for high-voltage systems, ensuring compliance with industry standards and delivering impactful projects...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Technical Services

$108K - $130K *

Lead the charge in overseeing JPATS Flight Operations, managing flight crew scheduling, and ensuring compliance with aviation safety standards while driving program efficiency and effectiveness...

4 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$100K - $155K *

Join a dynamic team to lead the deployment and support of cloud security solutions, ensuring optimal performance and customer satisfaction through expert technical guidance and strategic partnerships...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$117K - $176K *

Drive the development and governance of enterprise processes, ensuring alignment across operations and technology. Lead initiatives that enhance operational excellence and foster adoption of standardi...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$116K - $189K *

Transform partner marketing strategies by developing data-driven co-marketing plans, driving pipeline growth, and aligning sales teams with partners. Collaborate to create impactful campaigns and mana...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Transportation

$90K - $110K *

Join a team that's driving excellence in production planning and scheduling. Lead a dedicated group to optimize manufacturing processes, enhance operational efficiency, and ensure customer satisfactio...

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K *

Shape the future of our organization by providing visionary leadership, strategic direction, and operational oversight to achieve mission-driven goals while fostering partnerships and ensuring fiscal...

4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Accelerate progress at the forefront of digital transformation by managing complex data solutions. Collaborate with a global IT team to innovate and optimize SAP BW and BPC applications, driving effic...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$165K - $195K *

Join us to define and drive the product vision for Retail Experiences, enhancing guest journeys through innovative digital solutions. Collaborate across teams to create impactful, user-centric product...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.