Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $130K *

Lead the charge in maximizing product value by defining vision and backlog. Bridge business needs and technical delivery, guiding products through their lifecycle to ensure alignment with strategy, re...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$106K - $284K *

Drive innovation by leading the design and development of scalable software solutions, mentoring engineers, and collaborating with cross-functional teams to enhance patient care and clinical technolog...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $216K *

Redefine data governance by leading teams to implement sustainable AI solutions while managing client relationships and driving collaboration across various stakeholders for impactful results...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Business Services

$135K - $176K *

Grow your career by leading a pharmacy team dedicated to exceptional patient care. Drive best practices, enhance team performance, and ensure compliance while fostering a culture of safety and inclusi...

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $176K *

Lead the charge in transforming patient care by managing a dedicated pharmacy team, ensuring compliance, and fostering a culture of excellence while delivering exceptional service and support to patie...

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Transform financial operations by leading a dynamic team, ensuring accurate reporting, and driving strategic decisions that enhance value and growth in a fast-paced healthcare environment. Partner clo...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Reimagine project delivery by leading design teams and managing processes to ensure successful outcomes. Collaborate with stakeholders to create innovative solutions while maintaining compliance and q...

4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the development of our observability practice, creating dashboards and alerting systems to ensure uptime and reliability across enterprise tools. Build visibility from scratch, automate processes...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$87K - $110K *

Contribute to impactful education research by designing and conducting rigorous quantitative studies, synthesizing evidence, and translating findings into actionable insights for policy and practice...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Unlock potential by leading innovative product development for sauces and dips, utilizing scientific principles to enhance formulations and collaborate with cross-functional teams, ensuring quality an...

4 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$86K - $132K *

Champion the assessment and evaluation of individuals in a specialized program, conducting comprehensive reviews and reports while collaborating with legal and clinical teams to ensure effective treat...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a team that's shaping the future of transportation engineering. In this supervisory role, you'll provide expertise, develop policies, and ensure quality assurance for critical projects, all while...

4 days ago

  •   8 - 10 years exp.  •   Transportation

$80K - $95K *

Lead the charge in forensic psychology by conducting comprehensive evaluations for court-ordered cases. Collaborate with a diverse population while gaining mentorship for certification and board crede...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Lead the charge in new business development, leveraging multi-channel outreach to book quality meetings with target companies, while collaborating with a growth team to optimize your strategies and in...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Drive exceptional patient care by delivering health services as a Nurse Practitioner, collaborating with physicians and healthcare teams to enhance treatment outcomes and uphold the practice's mission...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $170K *

Join a team that's transforming digital services for Veterans by leading a skilled engineering group. You'll balance hands-on technical leadership with mentoring, driving the development of scalable J...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $140K *

Innovate cloud solutions by designing and automating infrastructure in Cloud.gov and Azure. Collaborate with teams to enhance performance and security, driving impactful results for clients while shap...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Champion innovation by designing and developing a cutting-edge routing engine for enterprise-scale contact centers, ensuring real-time distribution of interactions across various channels while collab...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$152K - $273K *

Elevate infrastructure innovation by architecting automated, resilient multi-cloud environments, driving AI-first operations, and implementing Zero Trust security protocols across enterprise systems f...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Information Technology

$125K - $150K *

Join a team that's redefining pharmacy automation by leading engineers to deliver impactful solutions. Drive team growth, manage processes, and collaborate with cross-functional partners to ensure suc...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $100K *

Engage with athletic programs nationwide, leading innovative standards for turf management while fostering relationships with directors and clients to enhance safety and performance in sports faciliti...

RemoteRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$112K - $134K *

Transform the internal audit landscape by leading technology audits, enhancing frameworks, and leveraging generative AI tools to optimize workflows and compliance across financial and operational cont...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Transform client relationships by driving new business opportunities within existing accounts. Leverage your sales expertise to identify needs, engage stakeholders, and collaborate with teams to deliv...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Lead the charge in optimizing our batching hardware portfolio, driving product strategy and lifecycle management. Collaborate with cross-functional teams to ensure seamless integration and support for...

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$165K - $190K *

Drive commerce strategy for major clients, translating ambitions into growth plans. Lead innovation, enhance quality, and build capabilities across the Commerce practice while fostering strong client...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.