Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Sr. Director, Global Engineering and EHS
$150K - $180K *
Transform the future of engineering and EHS by leading strategic initiatives, optimizing capital projects, and fostering a culture of safety and compliance across a global manufacturing network...
4 days ago
Senior Enterprise Solution Architect
$152K - $190K *
Unlock potential by delivering tailored data governance strategies and architectural designs for federal agencies, ensuring compliance and driving measurable outcomes while collaborating cross-functio...
4 days ago
Senior Journey Marketing Manager, Security
$105K - $141K *
Shape the future of customer engagement by leading integrated marketing journeys that drive security attachment and enhance customer experiences across multiple channels and teams, ensuring cohesive g...
4 days ago
Journeyman Electrician, Facility Services
$68K - $131K *
Grow your career with a hands-on role in facility maintenance, ensuring safety and functionality through inspections, repairs, and compliance with regulations. Collaborate with teams to enhance operat...
4 days ago
$98K - $172K *
Engage in impactful patient care by providing pharmaceutical services, counseling, and immunizations. Collaborate with pharmacy staff to ensure compliance and enhance customer relationships while advo...
4 days ago
Clinical Data Manager - REDCap/CTDB
$95K - $115K *
Unlock your potential by managing clinical data for impactful research. Collaborate with multidisciplinary teams to design databases, ensure compliance, and deliver high-quality data management soluti...
4 days ago
$155K - $185K *
Shape the future of digital shelf strategy across major retailers, driving content effectiveness and retail media efficiency. Lead a high-performing team to innovate and enhance client offerings, ensu...
4 days ago
Microsoft Dynamics Senior Consultant, Functional Transformation
$110K - $218K *
Lead transformative projects by designing integrated Microsoft Dynamics 365 solutions. Collaborate with multidisciplinary teams to enhance client business processes, ensuring alignment with technical...
4 days ago
Data Scientist- Remote opportunity
$95K - $115K *
Transform complex datasets into actionable insights by developing data-driven solutions for supply chain risk management. Collaborate with cross-functional teams to enhance military defense capabiliti...
Reposted 4 days ago
$80K - $95K *
Unlock potential by driving sales growth through strategic training and coaching in retail channels. Collaborate with teams to enhance performance and implement effective sales strategies, ensuring be...
4 days ago
Senior Director, Clinical Development (CNS)
$260K - $380K *
Shape the future of clinical development by leading global CNS portfolios, driving client success, and overseeing cross-functional teams to deliver exceptional outcomes in a fully remote environment w...
4 days ago
Senior Renewals Manager, Public Sector
$110K - $130K *
Drive customer retention by owning renewal strategies for public sector clients. Collaborate with Sales and Customer Success to enhance workflows, forecast outcomes, and ensure seamless renewal experi...
4 days ago
$66K - $100K *
Drive investigations into complex fraud cases, collaborating with teams and stakeholders to analyze evidence, prepare reports, and enhance anti-fraud training. Utilize your expertise to support claims...
4 days ago
$110K - $130K *
Execute comprehensive business development strategies in aviation and complex logistics. Identify, cultivate, and close high-value prospects while addressing mission-critical needs within the market...
Reposted 4 days ago
Staff Engineer, Team Lead - Core Infrastructure
$172K - $229K *
Build and lead a team to enhance platform testing and support for core infrastructure. Drive technical direction, manage incident response, and ensure software quality across systems, while collaborat...
4 days ago
Foundational Head of National Accounts, Enterprise Technology Partnerships
$135K - $160K *
Join a team that's redefining enterprise sales by leading strategic partnerships with large corporate insurance agencies and major institutions, driving growth through innovative technology solutions...
4 days ago
Senior Business Transformation Manager
$107K - $199K *
Unlock your potential by leading strategic initiatives that enhance operational efficiency through collaboration, process improvement, and organizational change management. Drive impactful results whi...
4 days ago
Account Solution Engineer - Enterprise Nonprofit Team
$134K - $180K *
Shape the future of nonprofit technology by leveraging your expertise to empower mission-driven organizations with innovative Salesforce solutions and strategic insights...
4 days ago
$79K - $127K *
Accelerate progress at our organization by leveraging your expertise in Mainframe technical solutions. Collaborate with cross-functional teams to design, develop, and maintain robust systems, ensuring...
4 days ago
$120K - $145K *
Empower the development of high-quality web interfaces by leading projects, mentoring engineers, and enhancing engineering processes. Collaborate on technical vision while fostering a culture of excel...
4 days ago
Marketo Engage Senior Technologist
$88K - $114K *
Transform client marketing strategies by leading automation implementations with Marketo Engage. Collaborate with stakeholders to design scalable solutions, ensuring high-quality execution and alignme...
4 days ago
Marketo Engage Senior Technologist
$88K - $114K *
Join a team that's redefining marketing automation by leading innovative implementations of Marketo Engage solutions, collaborating with stakeholders to enhance client experiences and drive strategic...
4 days ago
Marketo Engage Senior Technologist
$88K - $114K *
Empower our marketing initiatives by leading automation solutions with Marketo. Collaborate with teams to design, implement, and optimize advanced marketing strategies, ensuring alignment with client...
4 days ago
$140K - $160K *
Lead the charge in designing and enhancing AI systems for K-12 assessments, integrating cutting-edge technology with educational insights to create reliable, evaluative solutions that drive learning o...
4 days ago
$80K - $95K *
Elevate operational excellence by leading a maintenance team to ensure safe, efficient, and reliable manufacturing equipment performance while driving continuous improvement and alignment across funct...
4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.