Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$150K - $180K *

Transform the future of engineering and EHS by leading strategic initiatives, optimizing capital projects, and fostering a culture of safety and compliance across a global manufacturing network...

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$152K - $190K *

Unlock potential by delivering tailored data governance strategies and architectural designs for federal agencies, ensuring compliance and driving measurable outcomes while collaborating cross-functio...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$105K - $141K *

Shape the future of customer engagement by leading integrated marketing journeys that drive security attachment and enhance customer experiences across multiple channels and teams, ensuring cohesive g...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$68K - $131K *

Grow your career with a hands-on role in facility maintenance, ensuring safety and functionality through inspections, repairs, and compliance with regulations. Collaborate with teams to enhance operat...

4 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$98K - $172K *

Engage in impactful patient care by providing pharmaceutical services, counseling, and immunizations. Collaborate with pharmacy staff to ensure compliance and enhance customer relationships while advo...

4 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Unlock your potential by managing clinical data for impactful research. Collaborate with multidisciplinary teams to design databases, ensure compliance, and deliver high-quality data management soluti...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$155K - $185K *

Shape the future of digital shelf strategy across major retailers, driving content effectiveness and retail media efficiency. Lead a high-performing team to innovate and enhance client offerings, ensu...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Media

$110K - $218K *

Lead transformative projects by designing integrated Microsoft Dynamics 365 solutions. Collaborate with multidisciplinary teams to enhance client business processes, ensuring alignment with technical...

4 days ago

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Transform complex datasets into actionable insights by developing data-driven solutions for supply chain risk management. Collaborate with cross-functional teams to enhance military defense capabiliti...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Unlock potential by driving sales growth through strategic training and coaching in retail channels. Collaborate with teams to enhance performance and implement effective sales strategies, ensuring be...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$260K - $380K *

Shape the future of clinical development by leading global CNS portfolios, driving client success, and overseeing cross-functional teams to deliver exceptional outcomes in a fully remote environment w...

RemoteRemote

4 days ago

  •   11 - 15 years exp.  •   Staffing

$110K - $130K *

Drive customer retention by owning renewal strategies for public sector clients. Collaborate with Sales and Customer Success to enhance workflows, forecast outcomes, and ensure seamless renewal experi...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$66K - $100K *

Drive investigations into complex fraud cases, collaborating with teams and stakeholders to analyze evidence, prepare reports, and enhance anti-fraud training. Utilize your expertise to support claims...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Execute comprehensive business development strategies in aviation and complex logistics. Identify, cultivate, and close high-value prospects while addressing mission-critical needs within the market...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Transportation

$172K - $229K *

Build and lead a team to enhance platform testing and support for core infrastructure. Drive technical direction, manage incident response, and ensure software quality across systems, while collaborat...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Transportation

$135K - $160K *

Join a team that's redefining enterprise sales by leading strategic partnerships with large corporate insurance agencies and major institutions, driving growth through innovative technology solutions...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$107K - $199K *

Unlock your potential by leading strategic initiatives that enhance operational efficiency through collaboration, process improvement, and organizational change management. Drive impactful results whi...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$134K - $180K *

Shape the future of nonprofit technology by leveraging your expertise to empower mission-driven organizations with innovative Salesforce solutions and strategic insights...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$79K - $127K *

Accelerate progress at our organization by leveraging your expertise in Mainframe technical solutions. Collaborate with cross-functional teams to design, develop, and maintain robust systems, ensuring...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Empower the development of high-quality web interfaces by leading projects, mentoring engineers, and enhancing engineering processes. Collaborate on technical vision while fostering a culture of excel...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $114K *

Transform client marketing strategies by leading automation implementations with Marketo Engage. Collaborate with stakeholders to design scalable solutions, ensuring high-quality execution and alignme...

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $114K *

Join a team that's redefining marketing automation by leading innovative implementations of Marketo Engage solutions, collaborating with stakeholders to enhance client experiences and drive strategic...

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $114K *

Empower our marketing initiatives by leading automation solutions with Marketo. Collaborate with teams to design, implement, and optimize advanced marketing strategies, ensuring alignment with client...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $160K *

Lead the charge in designing and enhancing AI systems for K-12 assessments, integrating cutting-edge technology with educational insights to create reliable, evaluative solutions that drive learning o...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Elevate operational excellence by leading a maintenance team to ensure safe, efficient, and reliable manufacturing equipment performance while driving continuous improvement and alignment across funct...

4 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.