Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$120K - $145K *

Join us to lead the design and execution of innovative AI solutions within our Agentforce ecosystem. This role blends technical expertise in Salesforce with cross-functional collaboration to enhance o...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Media

$100K - $120K *

Join a team that's dedicated to advancing clinical trials by managing operations, analyzing data, and collaborating with diverse teams to ensure compliance and optimize outcomes for innovative treatme...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$50K - $500K *

Grow your career with a dynamic team as you lead a flight department, ensuring compliance, training, and exceptional service while fostering a culture of safety and integrity in aviation operations...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Transportation

$145K - $199K *

Engage with community physicians to enhance understanding of novel oncology diagnostics. Provide scientific leadership, facilitate educational growth, and identify collaboration opportunities to advan...

Kansas City, MORemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Champion sales growth by driving opportunities in CVO and SaaS solutions. Leverage your expertise to build relationships, manage pipelines, and close complex deals in the healthcare sector, ensuring c...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $92K *

Champion patient care by providing essential nursing services in diverse settings. Collaborate with an interdisciplinary team to deliver high-quality support, ensuring effective management of patient...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$82K - $110K *

Elevate your career by partnering with us to support higher education clients in crafting competitive grant proposals. Leverage your expertise in scientific research and grantsmanship to drive impactf...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$110K - $145K *

Join a team that's redefining observability architecture to enhance operational efficiency and service intelligence. Drive impactful outcomes across Managed Services by transforming monitoring practic...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $122K *

Drive customer success by managing relationships and service delivery for Managed Security Services. Collaborate with cross-functional teams to enhance security outcomes, ensure compliance, and realiz...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$170K - $200K *

Champion strategic ecosystem partnerships to drive revenue growth and enhance Acxiom's identity and data capabilities. Lead cross-functional teams in executing go-to-market strategies and building str...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Shape the future of data analytics by leveraging innovative technologies to develop scalable data products. Collaborate with cross-functional teams to ensure data quality and deliver actionable insigh...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $190K *

Transform your career by leading strategic partnerships within the Salesforce ecosystem. Drive growth through innovative go-to-market strategies, cross-functional collaboration, and executive relation...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$180K - $220K *

Pioneer enterprise project delivery by leading a high-performing team, ensuring strategic execution, financial performance, and operational readiness across complex programs and portfolios while foste...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$80K - $95K *

Transform operations by leading a dynamic team to ensure accuracy, compliance, and efficiency in departmental processes while fostering associate development and performance management...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Transform commercial real estate lending by managing loan portfolios, analyzing financials, and fostering client relationships while ensuring compliance with regulations and internal policies...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$109K - $144K *

Optimize client success by leveraging your Workday Payroll expertise to deliver exceptional post-production support, manage competing priorities, and mentor fellow consultants while driving project ef...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$64K - $97K *

Unlock potential by coordinating resource allocation for multiple projects, ensuring efficient staffing and communication across teams while maintaining accurate forecasts and productivity metrics...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$66K - $104K *

Contribute to innovative roadway design projects, collaborating with engineers and project managers to deliver high-quality solutions while enhancing your skills in a dynamic team environment...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$85K - $114K *

Drive your career with a rewarding role as a Registered Nurse, providing compassionate care to critically ill patients in a supportive environment. Collaborate with a dedicated team to ensure optimal...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$151K - $314K *

Transform global talent management by leading high-performance culture initiatives, driving data-driven strategies, and enhancing organizational effectiveness across diverse functions and geographies...

United StatesRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$71K - $110K *

Drive strategic performance insights by analyzing data, managing reporting processes, and enhancing coworker engagements to support informed decision-making and effective execution of strategic initia...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$97K - $115K *

Analyze implementation processes and program outcomes through advanced evaluation and research. Collaborate with partners to develop evaluation plans, conduct assessments, and provide technical assist...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$84K - $141K *

Shape data-driven strategies by leading analytics initiatives that optimize business decisions. Collaborate with teams to uncover insights, develop models, and create impactful visualizations that dri...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$121K - $176K *

Lead innovative controls engineering for multi-technology projects, ensuring design quality and consistency across wind, solar, and gas sectors. Mentor teams, drive technical standards, and collaborat...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $160K *

Join a dynamic team to lead employee relations in a project-based environment, ensuring consistent, high-quality investigations and support. Collaborate with leaders to foster a culture of accountabil...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.