Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$182K - $243K *

Shape the future of eCommerce by leading innovative health insurance solutions. Drive product strategy, enhance customer experiences, and collaborate across teams to deliver impactful results in a com...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$200K *

Lead our channel partnerships in digital health, driving commercial success and growth. Collaborate with cross-functional teams to enhance referral pathways, optimize partner engagement, and achieve r...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$126K - $149K *

Shape the future of institutional financing by managing and optimizing trading strategies, engaging with clients, and delivering tailored solutions across lending, margin, and shorting products in a d...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Pioneer growth in our Broker Channel by building relationships, managing a broker panel, and converting referrals into funded deals. This role offers the chance to shape strategy and expand into new r...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in academic excellence and strategic growth within the College of Education and Human Services, fostering collaboration, innovation, and community partnerships to enhance student succe...

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Shape the future of manufacturing by leading quality initiatives, driving innovation, and fostering a culture of excellence. Collaborate with leadership to enhance performance and customer satisfactio...

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Drive innovation in eCommerce by leading development of scalable front-end solutions. Collaborate with teams to create exceptional user experiences while optimizing performance and mentoring engineers...

Reposted 3 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Transform risk management by advising on financial planning activities, driving initiatives, and enhancing visibility into risk profiles. Collaborate with stakeholders to implement effective risk miti...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$128K - $193K *

Drive successful Microsoft 365 Managed Services engagements by overseeing technical delivery, maintaining client relationships, and providing expert guidance on complex solutions to ensure client sati...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Drive efficiency and innovation as you resolve complex technical inquiries, enhance processes, and support branch teams through data analysis and reporting. Collaborate with stakeholders to identify s...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Transform banking technology by designing and developing innovative applications that enhance client and advisor experiences. Collaborate with stakeholders to deliver scalable solutions while mentorin...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $250K *

Unlock revenue growth by leading a dynamic sales organization, driving enterprise strategies, and fostering collaboration across teams to achieve sustainable success in a high-growth environment...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $110K *

Join a team that's redefining legal accounting management by leading operational excellence, enhancing team performance, and ensuring top-tier client service across multiple law firm accounts...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$180K - $220K *

Drive strategic growth and client leadership in the Science and Tech market, leading high-performance teams to implement business plans and enhance brand presence while fostering innovative solutions...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$141K - $278K *

Transform product lifecycle processes by delivering innovative PLM solutions. Collaborate with cross-functional teams to address complex challenges, drive efficiency, and enhance client operations acr...

3 days ago

  •   5 - 7 years exp.  •   Business Services

$141K - $278K *

Join us to drive transformative Product Lifecycle Management solutions, collaborating with diverse teams to enhance operational efficiency and deliver impactful results across various industries, incl...

3 days ago

  •   5 - 7 years exp.  •   Business Services

$100K - $127K *

Champion partnerships with OEMs and strategic allies, driving collaboration and program development to enhance industry standards and support law enforcement initiatives. Lead efforts in data manageme...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Transform product strategy by leading impactful initiatives that enhance user experience and drive growth. Collaborate with cross-functional teams to deliver innovative solutions that delight customer...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Drive customer success by serving as a trusted technical partner, ensuring effective product adoption and communication between users and engineering teams. Leverage expertise to enhance workflows and...

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$200K *

Engage in a dynamic legal fellowship, gaining hands-on experience as a Summer Associate. Collaborate with mentors, enhance your legal writing, and contribute to impactful projects while preparing for...

3 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$171K - $326K *

Champion strategic project delivery by overseeing staff, budgets, and governance. Drive performance improvements and enhance organizational capabilities while aligning IT initiatives with business goa...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$123K - $167K *

Grow your career by managing key OEM accounts, driving sales, and enhancing customer satisfaction. Leverage your technical expertise and relationship-building skills to exceed revenue goals and foster...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$175K - $180K *

Drive legal excellence at the intersection of employment law and higher education. Collaborate with stakeholders to provide strategic guidance, influence policy development, and support compliance acr...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$139K - $185K *

Unlock your potential as a strategic Medical Affairs leader, driving evidence generation and enhancing patient care through cross-functional collaboration and innovative study management...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Contribute to the design and optimization of advanced electric motor technologies, collaborating across teams to deliver high-performance solutions that meet market demands while ensuring manufacturab...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.