Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$140K - $175K *

Accelerate progress at our company by driving growth within existing accounts. Leverage strategic relationships and insights to enhance customer success and maximize product adoption, ensuring long-te...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Transform applications by developing robust Java and Angular solutions, ensuring high performance and scalability. Collaborate with cross-functional teams to deliver seamless integrations and maintain...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Lead the charge in providing empathetic pharmacy consulting services, enhancing patient experiences, managing pharmacy operations, and developing staff while ensuring compliance with regulations and o...

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Champion regional marketing initiatives by building referral networks and enhancing patient care pathways. Collaborate with clinical teams to drive awareness and utilization of MR-guided Focused Ultra...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Join us to provide empathetic pharmacy consulting services, enhance patient experiences, manage pharmacy operations, and lead staff development while ensuring compliance with regulations and improving...

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Lead the charge in delivering exceptional pharmacy services, enhancing patient care through medication management, clinical consultations, and staff development while ensuring compliance with regulati...

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$140K - $190K *

Grow your career with a dynamic team leading innovative ad experiences. Drive product strategy through data-driven decisions while managing a cross-functional squad focused on quality and user trust i...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$125K - $150K *

Join a team that's defining strategies to win new business and drive growth. Lead capture development, engage stakeholders, and create compelling proposals to enhance competitive positioning and secur...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Business Services

$294K - $443K *

Lead the development and execution of a global operational risk management strategy, ensuring alignment with business objectives and regulatory requirements while fostering a strong risk culture acros...

3 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$120K - $145K *

Join a team that's dedicated to managing complex programs, ensuring client satisfaction and operational efficiency. Lead daily operations, supervise staff, and contribute to strategic initiatives whil...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$59K - $106K *

Innovate in the design of electric utility transmission systems, leading projects from conceptual routing to construction-ready packages. Collaborate with teams to enhance grid capacity and integrate...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Technical Services

$54K - $145K *

Champion provider engagement and onboarding of clinical data connections, enhancing efficiency and adoption within your assigned region by collaborating with various stakeholders and translating enter...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K *

Drive AI innovation by designing and scaling enterprise solutions that enhance business outcomes. Collaborate with cross-functional teams to ensure secure, compliant, and effective AI implementations...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$117K - $176K *

Help us redefine clinical development narratives by leading cross-functional teams to create compelling, strategic stories that enhance customer engagement and drive successful bid defenses, ultimatel...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$176K - $355K *

Elevate patient care by optimizing resource management and ensuring compliance. Collaborate with a multidisciplinary team to enhance documentation and coding practices while assessing medical necessit...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$182K - $243K *

Shape the future of eCommerce by leading innovative health insurance solutions. Drive product strategy, enhance customer experiences, and collaborate across teams to deliver impactful results in a com...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$200K *

Lead our channel partnerships in digital health, driving commercial success and growth. Collaborate with cross-functional teams to enhance referral pathways, optimize partner engagement, and achieve r...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$126K - $149K *

Shape the future of institutional financing by managing and optimizing trading strategies, engaging with clients, and delivering tailored solutions across lending, margin, and shorting products in a d...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Pioneer growth in our Broker Channel by building relationships, managing a broker panel, and converting referrals into funded deals. This role offers the chance to shape strategy and expand into new r...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in academic excellence and strategic growth within the College of Education and Human Services, fostering collaboration, innovation, and community partnerships to enhance student succe...

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Shape the future of manufacturing by leading quality initiatives, driving innovation, and fostering a culture of excellence. Collaborate with leadership to enhance performance and customer satisfactio...

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Drive innovation in eCommerce by leading development of scalable front-end solutions. Collaborate with teams to create exceptional user experiences while optimizing performance and mentoring engineers...

Reposted 3 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Transform risk management by advising on financial planning activities, driving initiatives, and enhancing visibility into risk profiles. Collaborate with stakeholders to implement effective risk miti...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$128K - $193K *

Drive successful Microsoft 365 Managed Services engagements by overseeing technical delivery, maintaining client relationships, and providing expert guidance on complex solutions to ensure client sati...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Drive efficiency and innovation as you resolve complex technical inquiries, enhance processes, and support branch teams through data analysis and reporting. Collaborate with stakeholders to identify s...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.