Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$146K - $271K *

Drive EHS initiatives across multiple locations, fostering a zero-harm culture while ensuring compliance and sustainability. Collaborate with stakeholders to implement strategic plans and enhance safe...

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$140K - $210K *

Lead the charge in delivering innovative integration solutions for clients in the State & Local Government sector. Collaborate with project teams to design, develop, and implement effective Workday in...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$95K - $115K *

Champion our event program by strategizing and executing impactful in-person and virtual experiences that drive engagement and measurable results, while managing logistics and cross-functional collabo...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$210K - $300K *

Join a dynamic team as a Games Product Manager, driving engagement and retention for a diverse portfolio of mobile and cloud titles. Collaborate with cross-functional partners to create compelling pla...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$105K - $141K *

Innovate your career by leading technical marketing strategies for cybersecurity solutions. Collaborate across functions to create impactful narratives, drive customer engagement, and enhance product...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$145K - $193K *

Join a high-impact team as you lead and coach TPMs and RTEs, ensuring successful technical program delivery and Agile execution across complex projects, while fostering collaboration and continuous im...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$105K - $155K *

Optimize the marketing automation ecosystem to enhance campaign execution, drive integration and operational excellence while collaborating with cross-functional teams to meet evolving business needs...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$159K - $254K *

Shape the future of pay solutions by driving innovative projects in back-end systems. Collaborate with cross-functional teams to enhance functionality and reliability, ensuring accurate payroll for re...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Drive innovation by building AI-first SaaS products, leading agentic development, and ensuring high-quality software delivery through collaborative engineering practices and robust CI/CD pipelines...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $155K *

Join a team that's redefining travel analytics by leveraging data to empower partners. As a Senior Data Scientist, you'll drive insights, automate reporting, and enhance decision-making across diverse...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$160K - $190K *

Deliver strategic assessments and solutions for federal information systems, ensuring compliance with NIST RMF and related standards. Collaborate with stakeholders to identify security gaps and provid...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $145K *

Join a dynamic team as you bridge client needs with tailored solutions, leveraging your expertise to drive project success and customer satisfaction through effective communication and collaboration a...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Media

$132K *

Lead the charge in bridging IT and program operations across the Americas, ensuring service delivery aligns with business needs. Build trust with leadership, manage escalations, and enhance communicat...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Lead the charge in managing premium client portfolios, guiding a skilled team to foster relationships and develop growth strategies across various verticals, maximizing both client success and agency...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$92K - $139K *

Lead the management of complex research portfolios, collaborating with faculty and sponsors to enhance project outcomes and streamline operations while ensuring compliance and effective resource alloc...

3 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $140K *

Elevate the future of AI-driven applications by designing and building reusable context assets. Collaborate with teams to ensure high-quality, governed context is integrated into production code, whil...

3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $95K *

Support the execution of technical projects, ensuring alignment with scope, schedule, and budget. Collaborate with cross-functional teams to deliver successful outcomes for food retail customers while...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Join a team that's driving innovation in food colors by identifying product opportunities, enhancing profitability, and managing lifecycles to support strategic growth and customer success in the food...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$90K *

Develop and maintain IT infrastructure solutions, ensuring optimal performance and security. Collaborate with teams to implement software, provide training, and enhance systems, while driving innovati...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$190K - $250K *

Launch a transformative Revenue Operations function to drive growth, partnering with leadership to design analytics, forecasting, and operational strategies that enhance performance across sales, mark...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$159K - $196K *

Oversee comprehensive partner audit efforts, ensuring compliance with standards, addressing concerns, and collaborating on solutions. Provide guidance, implement corrective actions, and keep leadershi...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Help us drive growth as an Enterprise Account Executive, engaging with top-tier clients to tackle fraud challenges using innovative solutions. Collaborate cross-functionally to shape strategies that e...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $92K *

Champion client relationships post-launch, ensuring retention and growth through strategic support and advocacy. Drive account success by uncovering opportunities, enhancing value, and achieving sales...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$215K - $235K *

Lead the charge in developing scalable enablement programs that enhance sales performance across customer-facing roles. Utilize your expertise in instructional design and AI to drive adoption, retenti...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Help us provide comprehensive psychiatric services to diverse clients, assessing and treating behavioral health disorders while collaborating with a dedicated team to enhance client care and outcomes...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.