Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$61K - $101K *

Join a team that's dedicated to enhancing workplace safety through consultation and training. Evaluate risks, develop loss control strategies, and foster strong relationships with clients to promote e...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$200K - $225K *

Join a dynamic team to drive growth and retention for US ISV partners across payments and money movement. Lead a team of account managers, design strategies, and enhance partner experiences to achieve...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Engineer seamless integrations and automation across systems, enhancing operational efficiency and collaboration. Leverage your expertise in SaaS platforms and APIs to drive innovative solutions in a...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $160K *

Transform project cost management by leading cost estimation and analysis for power generation projects. Drive accuracy at each design gate, ensuring compliance with AACE standards while identifying c...

3 days ago

  •   5 - 7 years exp.  •   Technical Services

$120K - $135K *

Transform the member experience by leading lifecycle marketing strategies that enhance engagement and retention across digital platforms. Drive campaign execution and optimize member journeys using da...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$157K - $184K *

Transform the future of container technology by designing and shipping innovative features for Chainguard Containers. Collaborate with a dynamic team to enhance security and performance while directly...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$83K - $135K *

Lead the charge in delivering expert technical leadership for complex power systems. Oversee startup, commissioning, and maintenance of advanced switchgear and controls, while mentoring junior enginee...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Shape the future of healthcare pricing analytics by leading payer contract modeling and team development. Utilize your expertise to optimize reimbursement strategies, enhance market intelligence, and...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $125K *

Drive impactful Salesforce solutions by leveraging advanced features and collaborating with teams to enhance system efficiency and user experience. Mentor junior developers while ensuring best practic...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Join a team that's shaping the future of data architecture, integrating innovative solutions across our enterprise ecosystem. Collaborate with diverse stakeholders to optimize and implement robust dat...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$70K - $116K *

Lead the cash posting and payment reconciliation for healthcare revenue cycles, ensuring accuracy and compliance. Drive team performance and enhance operational efficiency while managing payer relatio...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$110K - $150K *

Optimize automation initiatives to enhance business efficiency organization-wide. Collaborate with RPA specialists and stakeholders to identify opportunities, design solutions, and drive measurable im...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$155K - $185K *

Join a dynamic team to oversee security operations, incident response, and automation initiatives. Collaborate with cross-functional teams to enhance security practices and develop tools that streamli...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$185K - $260K *

Transform the AI-driven customer experience by leading the Superhuman Console product. Collaborate with cross-functional teams to enhance user engagement, streamline onboarding, and deliver impactful...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $150K *

Join a team that's dedicated to driving service excellence and profitability through effective management, customer relationships, and operational efficiency in a dynamic environment...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$200K - $275K *

Transform your career by owning the design and delivery of impactful features, collaborating with cross-functional teams to craft innovative software solutions that enhance user experiences and drive...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$116K - $194K *

Join a team that's driving sales strategies within the Department of War markets. Collaborate with experienced professionals to enhance market share and build relationships with key stakeholders in th...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Join us to streamline customer onboarding, ensuring a smooth transition from sales to production. You'll manage timelines, coordinate approvals, and enhance processes, driving efficiency and satisfact...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Contribute to innovative product strategies that enhance customer experiences and drive profitable growth in pharmacy solutions. Collaborate across teams to identify market needs, develop business cas...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$170K - $200K *

Join a dynamic team to design and implement scalable data pipelines, transforming diverse data sources into actionable insights. Collaborate with cross-functional experts to drive innovation and maint...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $100K *

Elevate your career by leading residential capital projects from inception to completion. Collaborate with cross-functional teams to ensure timely, budget-friendly delivery of managed WiFi solutions w...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$151K - $178K *

Lead the charge in operational excellence for strategic partners, managing billing, technical support, and reporting. Collaborate across teams to enhance partner engagement and drive growth through ef...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$146K - $271K *

Drive EHS initiatives across multiple locations, fostering a zero-harm culture while ensuring compliance and sustainability. Collaborate with stakeholders to implement strategic plans and enhance safe...

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$140K - $210K *

Lead the charge in delivering innovative integration solutions for clients in the State & Local Government sector. Collaborate with project teams to design, develop, and implement effective Workday in...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$95K - $115K *

Champion our event program by strategizing and executing impactful in-person and virtual experiences that drive engagement and measurable results, while managing logistics and cross-functional collabo...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.