Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$118K - $222K *

Drive the future of technology delivery by leading cross-functional teams to achieve business outcomes. Leverage Agile methodologies and emerging AI capabilities to enhance project execution, stakehol...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$118K - $222K *

Deliver impactful technology solutions by managing workstreams, engaging stakeholders, and driving business outcomes. Collaborate across teams to ensure effective delivery, mitigate risks, and optimiz...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$138K - $243K *

Unlock your potential as an Actuary, leading valuation processes and collaborating across teams to deliver insights for life insurance products. Drive improvements in standards and tools while ensurin...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $125K *

Lead the Procure-to-Pay workstream in a transformative ERP initiative, guiding design, validating functionality, and ensuring successful adoption of procurement and payment processes across the univer...

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$68K - $113K *

Empower your career by managing and settling property claims with professionalism and empathy. Collaborate with clients and stakeholders to ensure efficient resolutions while adapting to new technolog...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Take ownership of operational assessments to enhance effectiveness, identify risks, and drive performance improvements across functions. Collaborate with leaders to align practices with strategic goal...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$142K - $193K *

Lead the charge in engineering excellence by managing Loads & Dynamics teams, driving innovative solutions, and fostering employee growth while ensuring technical integrity in cutting-edge aerospace p...

3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Join a team that drives growth by expanding our partner ecosystem across North America. This role focuses on strategic channel sales, partner development, and revenue generation through effective rela...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K *

Launch your career as a Sales Agent, driving growth through member services and insurance products. Engage with clients, exceed sales goals, and enjoy comprehensive benefits while building a profitabl...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Join a team that's dedicated to managing complex litigation claims, overseeing strategy from filing to resolution. Collaborate with defense counsel and clients to ensure effective case management and...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Lead the charge in driving sales growth and market expansion through effective team leadership, strategic partnership development, and focused territory management, ensuring a high level of customer s...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$108K - $130K *

Optimize project management processes by leading governance, performance metrics, and cross-functional collaboration to enhance operational efficiency and drive business performance across the organiz...

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$78K - $130K *

Advance your career by managing complex appraisal reviews, ensuring compliance with regulations, and supporting the appraisal team in delivering accurate real estate valuations. Collaborate with colle...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$156K - $212K *

Elevate the training landscape by leading the design and execution of a comprehensive onboarding program for sales teams, fostering continuous improvement and collaboration across functions to enhance...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Join a team that's redefining manufacturing by building and managing a robust U.S. supplier network. Leverage your expertise in sourcing and supplier development to enhance performance, drive quality...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $200K *

Join a dynamic sales team and drive multifaceted relationships with major enterprise accounts. Leverage technical expertise to elevate manufacturing strategies, solve complex problems, and expand part...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$180K - $215K *

Lead the design and development of AI-driven acquisition systems, creating automated workflows and optimizing audience targeting to enhance customer engagement and retention in a data-rich environment...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$135K - $200K *

Lead the charge in expanding AutoQuotes sales within the foodservice manufacturing sector. Own the full sales cycle, engage with C-suite executives, and leverage AI tools to drive growth and efficienc...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Lead the analysis of complex business needs, bridging gaps between stakeholders and IT. Document requirements, validate solutions, and mentor junior analysts while ensuring project success and alignme...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$136K - $204K *

Join a dynamic team shaping the future of RFID technology through detailed layout design. Collaborate with cross-functional teams to enhance power efficiency and reliability, ensuring high-quality sil...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Shape the future of patient care by leading a dedicated nursing team, ensuring compliance with regulations, and enhancing quality standards in a dynamic healthcare environment. Drive operational excel...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $113K *

Drive operational excellence by partnering with Sales leadership to enhance planning, execution, and analytics. Shape processes that improve pipeline management and seller productivity, ensuring align...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$130K - $170K *

Elevate revenue operations by driving a unified GTM data strategy, delivering insights and analytics across teams to enhance decision-making and optimize performance in a senior individual contributor...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$240K - $260K *

Join a team that's redefining restaurant ordering systems. As a Staff Engineer, you'll architect resilient, event-sourced platforms, ensuring reliability and performance across thousands of devices wh...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Transform your career by leading regional marketing initiatives, building referral networks, and enhancing patient care pathways. Collaborate with healthcare professionals to drive awareness and utili...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.