Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$126K - $137K *
Champion user-centric software solutions by designing, developing, and maintaining applications. Collaborate throughout the software lifecycle to deliver high-quality products that meet customer needs...
3 days ago
Market Development Manager - Northeast
$110K - $130K *
Join a team that's redefining healthcare marketing by driving regional strategies and building referral networks. Collaborate with clinical teams to enhance patient pathways and community awareness, w...
3 days ago
$125K - $150K *
Shape the future of paid media strategy by advising brands on optimizing campaigns, enhancing performance, and driving growth through innovative advertising solutions and educational initiatives in a...
3 days ago
Digital Forensics Engagement Manager
$100K - $120K *
Champion digital forensics projects by managing workflows, budgets, and client expectations. Collaborate with teams to enhance service delivery, ensuring high client satisfaction and adherence to dead...
3 days ago
Lead Bioinformatics & Machine Learning Scientist
$146K - $182K *
Join a team that's advancing cancer detection through innovative machine learning models. Drive algorithm development and collaborate across disciplines to enhance tissue-free assays, ensuring high-qu...
3 days ago
Associate Medical Director - Market Access Marketing
$110K - $145K *
Elevate your career by leading strategic content development across diverse medical communications projects. Collaborate with cross-functional teams to ensure high-quality, accurate, and compliant con...
3 days ago
Senior Software Engineer, Search
$144K - $195K *
Join a team that's transforming the legal experience by developing innovative web applications. Collaborate with diverse teams, mentor junior engineers, and tackle complex challenges in a dynamic, agi...
3 days ago
Project Manager - Transportation Planning (Kansas City)
$95K - $115K *
Lead and manage transportation planning projects, ensuring successful delivery and client satisfaction while overseeing scope, budget, and multidisciplinary teams. Drive business development and maint...
3 days ago
$110K - $130K *
Accelerate progress at our growing company by driving sales for enterprise software, nurturing channel partnerships, and exceeding targets in a fast-paced environment that values commitment and innova...
Reposted 3 days ago
$130K - $155K *
Innovate your career by leading the technical direction of web systems, enhancing product reliability, and mentoring engineers. Embrace AI-first engineering to drive impactful solutions and foster col...
3 days ago
Sr Analyst, Claims Research (Medicaid Claims) Remote
$80K - $95K *
Join us to provide senior-level analyst support for claims research, ensuring timely resolution of provider claims issues. Leverage your expertise in medical claims processing and analytical skills to...
3 days ago
$80K - $95K *
Lead the design of user-centered digital experiences across platforms, blending creativity and technology. Collaborate with teams to create impactful solutions that engage users and align with strateg...
3 days ago
$113K - $188K *
Transform fraud risk management by leading initiatives, conducting assessments, and developing strategies. Collaborate with stakeholders to implement improvements and deliver high-quality documentatio...
3 days ago
$65K - $108K *
Optimize project delivery by coordinating Agile activities and enhancing contract management processes. Collaborate with federal stakeholders to track progress, manage risks, and ensure effective comm...
3 days ago
$85K - $90K *
Drive new business growth by building executive-level relationships with regional financial institutions, identifying opportunities, and delivering tailored cash management and security solutions to e...
3 days ago
$100K - $125K *
Join a team that's driving innovation in video and AI sales, shaping strategies and playbooks to expand market reach and revenue. Collaborate across functions to optimize customer engagement and enhan...
Reposted 3 days ago
$130K - $175K *
Lead the charge in transforming data solutions by collaborating with stakeholders and engineers to build robust data pipelines, ensuring accuracy and actionable insights for strategic decision-making...
Reposted 3 days ago
$85K - $90K *
Drive new business growth by building executive-level relationships with regional financial institutions, identifying opportunities, and delivering tailored cash management and security solutions acro...
3 days ago
$90K - $110K *
Help us elevate our claims process by managing litigated files, negotiating settlements, and collaborating with teams to enhance technology and processes. Your expertise will drive effective resolutio...
Reposted 3 days ago
$82K - $105K *
Join a team that’s pivotal in designing and maintaining software solutions to support the Tomahawk program. Contribute to all phases of the software lifecycle while ensuring industry and government co...
Reposted 3 days ago
Inventory Cost Accounting Manager
$115K - $130K *
Transform inventory accounting by leading a dedicated team to ensure accurate financial reporting and streamline processes across diverse operations, driving efficiency and clarity in COGS management...
3 days ago
$135K - $175K *
Empower your sales career by building and managing a robust pipeline through proactive prospecting and relationship-building. Thrive in a competitive environment where your performance directly impact...
3 days ago
Senior Software Engineer, Python
$170K - $200K *
Advance backend solutions and frontend features, collaborating across teams to build scalable systems and AI integrations, driving product growth from conception to execution...
Reposted 3 days ago
$150K - $180K *
Explore a pivotal role in shaping cloud infrastructure and DevOps practices. Lead initiatives to enhance software delivery, optimize processes, and mentor teams while ensuring compliance and security...
3 days ago
Director, CMC External Manufacturing
$210K - $235K *
Lead the charge in managing outsourced manufacturing operations, ensuring high-quality supply of clinical materials. Collaborate with cross-functional teams to drive operational excellence and complia...
3 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.