Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$180K *

Empower healthcare innovation by leading capital sales initiatives, engaging with clinicians and C-Suite stakeholders to drive adoption of advanced surgical technologies, and achieving revenue targets...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $196K *

Lead the charge in transforming client service operations, driving excellence and innovation. Collaborate with cross-functional teams to enhance customer satisfaction and deliver high-quality service...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $220K *

Manage and elevate a team of engineers to deliver AI-powered healthcare solutions. Oversee project planning, architecture, and team development while ensuring high-quality outcomes in a fast-paced, re...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$180K - $225K *

Lead the architectural strategy and engineering evolution of Salesforce, managing a high-performing team while ensuring scalability, reliability, and security in revenue systems. Drive innovative solu...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$135K - $160K *

Join a team that's redefining onboarding experiences by optimizing customer activation and conversion. You'll lead the charge in creating a seamless journey for new users, ensuring they derive value f...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$166K - $298K *

Join a team that's redefining small business lending through advanced ML models. You'll build and deploy critical models, partner with cross-functional teams, and set the technical standards for machi...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Drive innovation in clinical research by managing and optimizing information systems. Collaborate with multidisciplinary teams to ensure compliance and enhance data security while supporting genomic a...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Shape the future of social and behavioral research by leveraging advanced statistical methods and collaborating with multidisciplinary teams to analyze complex data and support impactful NIH-funded pr...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $160K *

Transform healthcare engagement by driving product adoption and brand awareness. Leverage your sales expertise to build relationships with key stakeholders, navigate access dynamics, and execute strat...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's dedicated to enhancing customer trust through effective escalation management. You'll coordinate complex incidents, advocate for clients, and lead resolution efforts across multiple...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Elevate customer success by leading a dynamic team focused on adoption, satisfaction, and advocacy. Collaborate across departments to enhance customer relationships and drive measurable outcomes while...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $105K *

Transform healthcare leadership by overseeing operations in a skilled nursing facility. Drive clinical excellence, foster teamwork, and enhance resident care while ensuring compliance and operational...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$192K - $252K *

Lead the execution of global medical strategies for hematology, ensuring patient-centered, evidence-driven activities. Collaborate with cross-functional teams to enhance scientific exchange and optimi...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $160K *

Oversee and manage a portfolio of complex Management Liability claims, including D&O, EPL, and Fiduciary Liability. Leverage technical expertise and strong judgment to achieve superior outcomes while...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$83K - $130K *

Champion innovation in healthcare by leveraging informatics to enhance clinical workflows, support EHR initiatives, and drive process improvements. Collaborate with diverse teams to ensure technology...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Drive cloud onboarding success by guiding application owners through migration complexities, ensuring effective communication and collaboration across teams to enhance operational efficiency and suppo...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $168K *

Champion strategic initiatives to scale partner operations, leading a global team to drive growth and enhance capabilities through effective execution and collaboration across functions...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Business Services

$144K - $222K *

Contribute to data-driven marketing strategies by analyzing insights, guiding teams, and identifying growth opportunities in pharma. Collaborate with leadership to enhance analytics capabilities and d...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Champion comprehensive dental care by delivering services and education, overseeing dental staff, and enhancing patient health in a community-focused environment while adhering to best practices and r...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Lead the charge in transforming employer benefits by driving sales growth in the Mid-Atlantic region. Collaborate with teams to manage client relationships and contribute to product development while...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$80K - $95K *

Take ownership of AI quality assurance by ensuring the accuracy and reliability of AI data extraction processes. Collaborate with stakeholders to maintain ground-truth datasets and enhance evaluation...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $190K *

Unlock potential by leading the design and integration of advanced satellite communications systems. Drive system architecture, manage requirements, and collaborate across multi-disciplinary teams to...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$150K - $180K *

Drive impactful financial solutions by leading teams and transforming data into strategic insights. Collaborate with stakeholders to enhance processes and deliver high-quality results that support inf...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $200K *

Join a team that's redefining technology foundations to empower innovation. Lead the strategy and operations of core infrastructure, driving modernization and automation while collaborating with engin...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$135K - $175K *

Transform the sales landscape by driving growth through proactive prospecting, relationship building, and closing deals in the home improvement sector. Join a dynamic team focused on achieving targets...

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.