Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$87K - $100K *

Unlock potential by leading complex WAN/LAN network solutions, mentoring IT staff, and driving technology decisions to enhance infrastructure security and reliability while tackling challenging techni...

Today

  •   8 - 10 years exp.  •   Information Technology

$110K - $145K *

Empower enterprise growth by managing high-value accounts in a dynamic SaaS environment. Drive the full sales cycle, build executive relationships, and navigate complex negotiations to achieve impactf...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$110K - $166K *

Lead the charge in end-to-end UX design for digital products, collaborating with cross-functional teams to deliver customer-centered solutions that enhance satisfaction and drive business results acro...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$153K *

Shape strategic transactions as the Deal Desk lead for North America, collaborating with Sales and cross-functional teams to enhance deal structure, execution, and compliance while optimizing processe...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$180K - $220K *

Join a team that's transforming healthcare by integrating innovative solutions with partners. Collaborate closely with technical teams to deliver seamless integrations and enhance user experiences fro...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$134K - $249K *

Shape the future of vendor management by leading strategic partnerships, ensuring compliance, and optimizing performance across dental, vision, pharmacy, and transportation services, all while managin...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$160K - $230K *

Join a team that's redefining product engineering by owning high-impact areas from concept to launch. Collaborate closely with leadership to enhance user experiences and drive innovation in a fast-pac...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Drive strategic business development initiatives in Electronic Warfare, expanding market presence and fostering relationships with US DoD customers. Leverage expertise to identify opportunities, gener...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Aerospace & Defense

$80K - $95K *

Join a dynamic team as a technical liaison, driving innovative solutions and enhancing customer satisfaction through expert application engineering and sales support across diverse industrial systems...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$68K - $107K *

Champion the administration of clinical trials by managing documentation, supplies, and regulatory submissions. Collaborate with cross-functional teams to ensure timely site readiness and compliance w...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead and manage design-build projects, ensuring timely completion within budget while meeting client objectives and contractual obligations. Oversee scope development, financial performance, and compl...

United StatesRemote

Reposted today

  •   15+ years exp.  •   Transportation

$120K - $155K *

Join a team that's dedicated to nurturing and expanding client relationships in the Major Market sector. Drive revenue growth through upselling and cross-selling while ensuring long-term satisfaction...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$120K - $150K *

Unlock potential by driving sales strategy and growth in the Southeast. Lead key accounts, identify new business opportunities, and collaborate with teams to deliver exceptional solutions while achiev...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Consumer Technology

$145K - $290K *

Shape the future of Digital Pathology by driving strategic initiatives that enhance customer value and achieve commercial growth across North America, collaborating with cross-functional teams to meet...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Drive IT operations and support in a fast-growing environment, enhancing processes and automating workflows. Collaborate with cross-functional teams to scale IT infrastructure as the company expands f...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Optimize AI security capabilities by owning product strategy, synthesizing market research, and leading cross-functional collaboration to enhance agentic workloads and secure AI systems against evolvi...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $125K *

Transform your career by collaborating with the Sales Operations team to implement strategies, enhance reporting, and drive business goals in a dynamic, remote environment. Your analytical skills will...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a dynamic team to enhance operational workflows for autonomous trucking. Lead process design, maintain quality standards, and drive continuous improvement across multiple workstreams while collab...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$135K - $176K *

Join a team that's dedicated to enhancing financial accuracy and compliance. Collaborate with finance leaders to improve reporting processes, assist with audits, and analyze data, all while managing m...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$115K - $159K *

Join a team that's dedicated to driving customer success through tailored financial solutions, utilizing technical expertise and effective collaboration within a fast-paced environment to meet evolvin...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$150K - $189K *

Transform global labeling strategies into actionable regional plans, ensuring compliance and quality. Oversee document preparation, vendor management, and cross-functional approvals to deliver timely...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$123K - $202K *

Join our agile team to design and develop cutting-edge Esri software for raster and imagery workflows in ArcGIS Pro using C#, WPF, and C++. Collaborate to create innovative user interfaces while ensur...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$98K - $173K *

Empower businesses by leveraging GIS technology to solve complex spatial challenges. As a geospatial expert, engage with clients to demonstrate innovative solutions and strategies that drive impactful...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$93K - $158K *

Support critical national security missions by managing program security requirements, collaborating with government customers, and ensuring compliance in classified environments to enable secure miss...

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$160K - $195K *

Shape the future of payroll and HRIS integrations by ensuring reliability and success. Collaborate with customers and partners to solve technical challenges and enhance the integration experience whil...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.