Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $116,335
$87K - $100K *
Unlock potential by leading complex WAN/LAN network solutions, mentoring IT staff, and driving technology decisions to enhance infrastructure security and reliability while tackling challenging techni...
Today
Client Sales Enterprise Account Executive
$110K - $145K *
Empower enterprise growth by managing high-value accounts in a dynamic SaaS environment. Drive the full sales cycle, build executive relationships, and navigate complex negotiations to achieve impactf...
Reposted today
Senior User Experience Designer
$110K - $166K *
Lead the charge in end-to-end UX design for digital products, collaborating with cross-functional teams to deliver customer-centered solutions that enhance satisfaction and drive business results acro...
Reposted today
Senior Manager, Deal Desk - North America
$153K *
Shape strategic transactions as the Deal Desk lead for North America, collaborating with Sales and cross-functional teams to enhance deal structure, execution, and compliance while optimizing processe...
Reposted today
Forward Deployed Product Engineer (Client Facing)
$180K - $220K *
Join a team that's transforming healthcare by integrating innovative solutions with partners. Collaborate closely with technical teams to deliver seamless integrations and enhance user experiences fro...
Today
Senior Director, Vendor Partnerships
$134K - $249K *
Shape the future of vendor management by leading strategic partnerships, ensuring compliance, and optimizing performance across dental, vision, pharmacy, and transportation services, all while managin...
Today
$160K - $230K *
Join a team that's redefining product engineering by owning high-impact areas from concept to launch. Collaborate closely with leadership to enhance user experiences and drive innovation in a fast-pac...
Today
Senior Manager, BD - Electronic Warfare
$120K - $145K *
Drive strategic business development initiatives in Electronic Warfare, expanding market presence and fostering relationships with US DoD customers. Leverage expertise to identify opportunities, gener...
Today
$80K - $95K *
Join a dynamic team as a technical liaison, driving innovative solutions and enhancing customer satisfaction through expert application engineering and sales support across diverse industrial systems...
Today
Clinical Trial Coordinator - Monitoring (Remote)
$68K - $107K *
Champion the administration of clinical trials by managing documentation, supplies, and regulatory submissions. Collaborate with cross-functional teams to ensure timely site readiness and compliance w...
Today
Sr. Design-Build Project Manager
$125K - $150K *
Lead and manage design-build projects, ensuring timely completion within budget while meeting client objectives and contractual obligations. Oversee scope development, financial performance, and compl...
Reposted today
$120K - $155K *
Join a team that's dedicated to nurturing and expanding client relationships in the Major Market sector. Drive revenue growth through upselling and cross-selling while ensuring long-term satisfaction...
Reposted today
$120K - $150K *
Unlock potential by driving sales strategy and growth in the Southeast. Lead key accounts, identify new business opportunities, and collaborate with teams to deliver exceptional solutions while achiev...
Today
Enterprise Informatics Regional Category Leader - Digital Pathology
$145K - $290K *
Shape the future of Digital Pathology by driving strategic initiatives that enhance customer value and achieve commercial growth across North America, collaborating with cross-functional teams to meet...
Today
$95K - $115K *
Drive IT operations and support in a fast-growing environment, enhancing processes and automating workflows. Collaborate with cross-functional teams to scale IT infrastructure as the company expands f...
Today
$125K - $150K *
Optimize AI security capabilities by owning product strategy, synthesizing market research, and leading cross-functional collaboration to enhance agentic workloads and secure AI systems against evolvi...
Reposted today
$75K - $125K *
Transform your career by collaborating with the Sales Operations team to implement strategies, enhance reporting, and drive business goals in a dynamic, remote environment. Your analytical skills will...
Today
Program Manager, Operations Process
$110K - $130K *
Join a dynamic team to enhance operational workflows for autonomous trucking. Lead process design, maintain quality standards, and drive continuous improvement across multiple workstreams while collab...
Today
$135K - $176K *
Join a team that's dedicated to enhancing financial accuracy and compliance. Collaborate with finance leaders to improve reporting processes, assist with audits, and analyze data, all while managing m...
Today
Solutions Consultant, Commercial
$115K - $159K *
Join a team that's dedicated to driving customer success through tailored financial solutions, utilizing technical expertise and effective collaboration within a fast-paced environment to meet evolvin...
Reposted today
Senior Manager, Regulatory Affairs Labeling
$150K - $189K *
Transform global labeling strategies into actionable regional plans, ensuring compliance and quality. Oversee document preparation, vendor management, and cross-functional approvals to deliver timely...
Today
Sr. Software Developer - C#/WPF for UI/UX Development
$123K - $202K *
Join our agile team to design and develop cutting-edge Esri software for raster and imagery workflows in ArcGIS Pro using C#, WPF, and C++. Collaborate to create innovative user interfaces while ensur...
Reposted today
Sr. GIS Solution Engineer - AEC
$98K - $173K *
Empower businesses by leveraging GIS technology to solve complex spatial challenges. As a geospatial expert, engage with clients to demonstrate innovative solutions and strategies that drive impactful...
Reposted today
Contractor Program Security Officer (CPSO) - TS/SCI
$93K - $158K *
Support critical national security missions by managing program security requirements, collaborating with government customers, and ensuring compliance in classified environments to enable secure miss...
Reposted today
$160K - $195K *
Shape the future of payroll and HRIS integrations by ensuring reliability and success. Collaborate with customers and partners to solve technical challenges and enhance the integration experience whil...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.